ASCC2 (NM_032204) Human Untagged Clone

CAT#: SC319600

ASCC2 (untagged)-Human activating signal cointegrator 1 complex subunit 2 (ASCC2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: ASCC2
• Synonyms: ASC1p100; p100
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_032204.3 CCGGAAGTGCGGGCGCTCAGGGAGCTGTCACCGTGGTCGGCGGCGGCGGCGGCGGCGGCG
  GCACAGAGCCGGTGGTGGAGCCGCCGAGGAGGGTCACGCAGCACAATGCCAGCTCTGCCC
  CTGGACCAACTCCAGATCACCCACAAGGACCCGAAGACAGGAAAGCTGAGGACTTCACCA
  GCGCTGCACCCCGAGCAGAAGGCAGACCGGTATTTTGTGTTATACAAACCGCCCCCTAAA
  GACAACATTCCCGCCCTAGTGGAGGAGTACCTGGAACGCGCCACCTTCGTAGCCAATGAC
  CTCGACTGGCTCCTGGCCTTGCCTCACGATAAATTCTGGTGCCAGGTGATCTTTGACGAG
  ACTCTACAGAAGTGCCTGGACTCCTACCTGCGCTATGTCCCCCGCAAATTCGACGAGGGG
  GTGGCCTCAGCCCCTGAGGTTGTTGACATGCAGAAGCGCCTCCATCGAAGTGTTTTTCTC
  ACCTTCCTCCGCATGTCCACTCACAAGGAATCCAAAGATCACTTCATTTCCCCTTCTGCG
  TTTGGAGAAATCCTCTACAATAACTTCCTCTTTGACATTCCAAAGATCCTGGACCTCTGC
  GTGCTCTTTGGAAAAGGCAACTCACCACTGCTCCAGAAGATGATAGGAAACATCTTTACA
  CAGCAGCCAAGTTACTACAGTGACCTGGATGAAACCCTGCCTACCATCCTTCAGGTCTTC
  AGCAATATCCTCCAGCACTGTGGTTTGCAAGGGGACGGGGCCAATACCACACCCCAGAAG
  CTTGAGGAGAGGGGCCGATTGACCCCCAGTGACATGCCTCTCCTGGAATTAAAGGACATT
  GTTCTCTACCTTTGTGATACCTGCACCACACTTTGGGCCTTTCTGGATATCTTCCCTTTG
  GCTTGCCAGACCTTCCAGAAGCACGACTTTTGTTACAGACTAGCTTCCTTCTACGAAGCA
  GCAATTCCCGAAATGGAGTCTGCAATTAAGAAGAGGAGGCTTGAAGATAGCAAGCTTCTT
  GGTGACCTGTGGCAGAGGCTCTCCCATTCCAGGAAGAAGCTAATGGAGATTTTCCACATC
  ATCCTGAACCAGATCTGCCTCCTTCCCATCCTAGAAAGCAGCTGTGACAACATTCAGGGC
  TTCATCGAAGAGTTCCTTCAGATCTTCAGCTCCTTGCTGCAGGAGAAGAGGTTCCTCCGG
  GACTATGATGCACTCTTCCCCGTGGCCGAAGACATCAGCTTGCTGCAGCAGGCCTCATCA
  GTCTTGGACGAGACGCGGACTGCCTACATCCTCCAGGCAGTCGAGAGTGCATGGGAAGGG
  GTGGACAGACGGAAAGCCACAGATGCTAAAGACCCATCGGTGATTGAGGAGCCTAATGGG
  GAGCCTAACGGGGTCACGGTGACAGCAGAGGCAGTCAGTCAAGCATCATCACATCCGGAG
  AACTCGGAGGAAGAGGAGTGCATGGGAGCAGCCGCGGCTGTGGGCCCTGCCATGTGTGGG
  GTGGAACTGGACTCTCTCATCTCCCAAGTGAAGGACCTGCTGCCAGACCTTGGTGAGGGC
  TTCATCCTGGCCTGCCTGGAGTACTACCACTACGACCCAGAGCAGGTGATCAACAATATC
  CTGGAGGAGCGGCTGGCCCCCACCCTCAGCCAGCTGGACCGCAACCTAGACAGAGAAATG
  AAACCAGACCCTACACCCCTGCTGACGTCTCGCCACAACGTCTTCCAGAATGACGAGTTT
  GATGTGTTCAGCAGGGACTCAGTAGACCTGAGCCGGGTGCACAAGGGCAAGAGCACCAGG
  AAGGAGGAAAACACGCGGAGTTTGCTGAACGACAAGCGTGCAGTGGCGGCACAGCGGCAG
  CGCTACGAGCAGTACAGCGTGGTGGTGGAGGAGGTGCCACTGCAGCCAGGCGAGAGCCTG
  CCCTACCACAGTGTCTACTACGAGGATGAGTACGATGACACATACGATGGCAACCAGGTG
  GGCGCCAATGATGCAGACTCTGATGACGAGCTCATCAGCCGCAGGCCATTCACCATCCCT
  CAGGTGCTGAGAACCAAAGTGCCTAGAGAAGGGCAGGAGGAGGATGACGACGATGAGGAA
  GACGATGCTGACGAGGAGGCTCCCAAGCCCGACCATTTTGTTCAGGACCCTGCAGTGCTG
  AGAGAGAAGGCAGAAGCCAGGCGCATGGCCTTTCTCGCCAAGAAAGGGTACCGGCATGAC
  AGCTCAACAGCAGTGGCCGGCAGCCCCCGAGGCCATGGGCAGAGCCGCGAGACAACCCAG
  GAACGCAGGAAGAAGGAAGCCAACAAGGCGACAAGAGCCAACCACAACCGGAGAACCATG
  GCCGACCGCAAGAGGAGCAAAGGCATGATCCCATCCTGAGACCTGGTGCAGGGCCAGTGG
  GGAGGCAGCGGCACCAGACTCACCAGGCCGTGCTCCCATCGCCTGGGGCCTCCTCACTAG
  GGGCCCCAAGTTCAACTCAACCCCTCAACAGCCTCAGCTTTGCAGCCCCTGAGAAGGCCG
  CCTCTCATCTACCAGCCAGCCATGAGCGCCTTCCTGCAGAACACACAGTGCCTTATGCCA
  CAGCCGAAGAATCCGTGGGGCCGGCAAGCAGGCACCTTCCCCCAGCTGCGCTAGCGGGAA
  AGAGATGGGGATGGAGTCCCAAGGCAAGCGCCCCAAACCTCGGGCCACAAGACACCACTT
  CCCCTTTACCCTGGACAGCAGGAAACCTGTATATTCAAAAACACAAAAAGTCCTGCTAAT
  AAAATTTTTGACCCTTTCAAAAAAAAAAAAAAAAAAAAA
• Restriction Sites: Please inquire
• ACCN: NM_032204
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_032204.3, NP_115580.2
• RefSeq Size: 2799 bp
• RefSeq ORF: 2274 bp
• Locus ID: 84164
• UniProt ID: Q9H1I8
• Cytogenetics: 22q12.2
• Domains: CUE
• Protein Families: Druggable Genome, Transcription Factors
• Gene Summary: Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347).[UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).