Drebrin (DBN1) (NM_004395) Human Untagged Clone

CAT#: SC319386

DBN1 (untagged)-Human drebrin 1 (DBN1), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: Drebrin
• Synonyms: D0S117E
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_004395.2 CCGAGGCGGCGGCGGCGACTCCCTCTTTCCCTCCCTCCTCCTCCGTCCGCCCGTCCGTCC
  GCGCGTCTGTCCGTTCGGCCCGGTCCGGCCCGAAGCATGGCCGGCGTCAGCTTCAGCGGC
  CACCGCCTGGAGCTGCTGGCGGCTTACGAGGAGGTGATCCGAGAGGAGAGCGCGGCCGAC
  TGGGCTCTGTACACATATGAAGATGGCTCCGATGACCTCAAGCTTGCAGCATCAGGAGAA
  GGGGGCTTGCAGGAGCTTTCGGGACACTTTGAGAACCAGAAGGTGATGTACGGCTTCTGC
  AGTGTCAAGGACTCCCAAGCTGCTCTGCCAAAATACGTGCTCATCAACTGGGTGGGCGAA
  GATGTGCCTGATGCCCGCAAGTGCGCTTGTGCCAGCCACGTGGCTAAGGTGGCAGAGTTC
  TTCCAGGGTGTCGACGTGATCGTGAACGCCAGCAGCGTGGAAGACATAGACGCGGGTGCC
  ATCGGGCAGCGGCTCTCTAACGGGCTGGCGCGACTCTCCAGCCCTGTGCTGCACCGACTG
  CGGCTGCGAGAGGATGAGAACGCAGAGCCCGTGGGCACCACCTACCAGAAGACGGATGCA
  GCTGTGGAAATGAAGCGGATTAACCGAGAGCAGTTCTGGGAGCAGGCCAAGAAGGAAGAA
  GAGCTGCGGAAGGAGGAGGAGCGGAAGAAGGCCCTGGATGAGAGGCTCAGGTTCGAGCAG
  GAGCGGATGGAGCAGGAGCGGCAGGAGCAAGAGGAGCGCGAGCGGCGCTACCGGGAGCGG
  GAGCAGCAGATCGAGGAGCACAGGAGGAAACAGCAGACTTTAGAAGCGGAAGAGGCCAAG
  AGGCGGTTGAAGGAGCAGTCTATCTTTGGTGACCATCGGGATGAGGAGGAAGAGACCCAC
  ATGAAGAAGTCAGAGTCGGAGGTGGAGGAGGCAGCAGCTATTATTGCCCAGCGGCCTGAC
  AACCCAAGGGAGTTCTTCAAGCAGCAGGAAAGAGTCGCATCGGCCTCTGCGGGCAGCTGT
  GATGTACCCTCGCCCTTCAACCATCGACCAGGCAGCCACCTGGACAGCCACCGGAGGATG
  GCGCCCACTCCCATCCCCACGCGGAGCCCGTCTGACTCCAGCACCGCCTCCACCCCTGTC
  GCTGAGCAGATAGAGCGGGCCCTGGATGAGGTCACCTCCTCGCAGCCTCCACCACTGCCA
  CCGCCACCCCCACCAGCCCAAGAGACCCAGGAGCCCAGCCCCATCCTAGACAGTGAGGAG
  ACCAGAGCAGCAGCCCCTCAGGCCTGGGCCGGCCCCATGGAGGAGCCCCCTCAGGCACAG
  GCGCCTCCCCGGGGGCCAGGCAGCCCTGCAGAGGACTTGATGTTCATGGAGTCTGCAGAG
  CAGGCTGTCCTGGCTGCTCCCGTGGAGCCTGCCACAGCTGACGCCACGGAGGTCCACGAT
  GCAGCTGACACCATTGAAACTGACACTGCCACTGCTGACACCACTGTTGCCAACAACGTA
  CCCCCCGCCGCCACCAGCCTCATTGACCTATGGCCTGGCAACGGGGAAGGGGCCTCCACA
  CTCCAGGGTGAGCCCAGGGCCCCCACGCCACCCTCGGGTACTGAGGTCACCCTGGCAGAG
  GTGCCCCTGCTGGATGAGGTGGCTCCGGAGCCACTGCTGCCAGCAGGCGAAGGCTGTGCC
  ACCCTTCTCAACTTTGATGAGCTGCCTGAGCCGCCAGCCACCTTCTGTGACCCAGAGGAA
  GTGGAAGGGGAGCCCCTGGCTGCCCCCCAGACCCCAACTCTGCCCTCAGCCCTTGAGGAG
  CTGGAGCAAGAGCAGGAGCCGGAGCCCCACCTGCTAACCAATGGCGAGACCACCCAGAAG
  GAGGGGACCCAGGCCAGTGAGGGGTACTTCAGTCAATCACAGGAGGAGGAGTTTGCCCAA
  TCGGAAGAGCTCTGTGCCAAGGCTCCGCCTCCTGTGTTCTACAACAAGCCTCCAGAGATC
  GACATCACATGCTGGGATGCAGACCCAGTTCCAGAAGAGGAGGAGGGCTTCGAGGGTGGT
  GATTAGCGGTGGCGCCAGCCCTAGGCTACCCTTGCCAAGGCCGCCCACCTGCATCAGCCT
  CTGGCCAGACGGCCCGCCGTGCCTGCATTCGCAGCAGCTCCGCCTGGCACCCACTCCGGA
  TTCCGGCCCTGGCTGGGGACTTGGCCGCTTCCCTACCCACAGGGCCTGACTTTTACAGCT
  TTTCTCTTTTTTTAAAAAGTTGATAGGAGACTTGTACAGTTGACTGGCTTTCCTCTCGTT
  GGTAGTTGAGACGCTGTTGCAAATTCCACCCCTCCTTCCCTGGTCCAGATTGTAGCTCTT
  AGTCCTCCCTGCTCAGCTGGCCGGGTTGGAGGCCTCACCCTGCTTGGGGCCTGGCGTGGG
  GGGAGCTCTGGTGGGAAAATGTCCCCCACCTCTTTTCCTAGTTTTATGTTTCTTGGGAAA
  ATATCACTTTGTATTCTCTGTCCAGGGCTTCAGATATTTTGCACGAATTTTAAAACATGG
  CAATAAATGGCTCGTGGGCTCTGGCAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
  AAAAAAAAAAAAA
• Restriction Sites: Please inquire
• ACCN: NM_004395
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA.
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_004395.2, NP_004386.2
• RefSeq Size: 2910 bp
• RefSeq ORF: 1950 bp
• Locus ID: 1627
• UniProt ID: Q16643
• Cytogenetics: 5q35.3
• Domains: ADF
• Gene Summary: The protein encoded by this gene is a cytoplasmic actin-binding protein thought to play a role in the process of neuronal growth. It is a member of the drebrin family of proteins that are developmentally regulated in the brain. A decrease in the amount of this protein in the brain has been implicated as a possible contributing factor in the pathogenesis of memory disturbance in Alzheimer's disease. At least two alternative splice variants encoding different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
  Transcript Variant: This variant (1) encodes the predominant isoform (a).