IFNGR2 (NM_005534) Human Untagged Clone

SKU SC319060

IFNGR2 (untagged)-Human interferon gamma receptor 2 (interferon gamma transducer 1) (IFNGR2)

Product Data

• Type: Human Untagged Clone
• Target Symbol: IFNGR2
• Synonyms: AF-1; IFGR2; IFNGT1; IMD28
• Vector: pCMV6-AC
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_005534 edited; GCGGGCCCTGCGCGCCCTGCGCTCGCCATGGCGGTTTGGGCGGCGACGTGAGCGGCTCCG; CGGACCCCGAGCGGGGCCCCGGCCGCGACCTGAGCCGCCGCCGAGCGCCCGGGGCCATGC; GACCGACGCTGCTGTGGTCGCTGCTGCTGCTGCTCGGAGTCTTCGCCGCCGCCGCCGCGG; CCCCGCCAGACCCTCTTTCCCAGCTGCCCGCTCCTCAGCACCCGAAGATTCGCCTGTACA; ACGCAGAGCAGGTCCTGAGTTGGGAGCCAGTGGCCCTGAGCAATAGCACGAGGCCTGTTG; TCTACCAAGTGCAGTTTAAATACACCGACAGTAAATGGTTCACGGCCGACATCATGTCCA; TAGGGGTGAATTGTACACAGATCACAGCAACAGAGTGTGACTTCACTGCCGCCAGTCCCT; CAGCAGGCTTCCCAATGGATTTCAATGTCACTCTACGCCTTCGAGCTGAGCTGGGAGCAC; TCCATTCTGCCTGGGTGACAATGCCTTGGTTTCAACACTATCGGAATGTGACTGTCGGGC; CTCCAGAAAACATTGAGGTGACCCCAGGAGAAGGCTCCCTCATCATCAGGTTCTCCTCTC; CCTTTGACATCGCTGATACCTCCACGGCCTTTTTTTGTTATTATGTCCATTACTGGGAAA; AAGGAGGAATCCAACAGGTCAAAGGCCCTTTCAGAAGCAACTCCATTTCATTGGATAACT; TAAAACCCTCCAGAGTGTACTGTTTACAAGTCCAGGCACAACTGCTTTGGAACAAAAGTA; ACATCTTTAGAGTCGGGCATTTAAGCAACATATCTTGCTACGAAACAATGGCAGATGCCT; CCACTGAGCTTCAGCAAGTCATCCTGATCTCCGTGGGAACATTTTCGTTGCTGTCGGTGC; TGGCAGGAGCCTGTTTCTTCCTGGTCCTGAAATATAGAGGCCTGATTAAATACTGGTTTC; ACACTCCACCAAGCATCCCATTACAGATAGAAGAGTATTTAAAAGACCCAACTCAGCCCA; TCTTAGAGGCCTTGGACAAGGACAGCTCACCAAAGGATGACGTCTGGGACTCTGTGTCCA; TTATCTCGTTTCCGGAAAAGGAGCAAGAAGATGTTCTCCAAACGCTTTGAACCAAAGCAT; GGGCCTAGCCCACTGGCTCCCTGGAAGAGATCAAGCCATCGGAGCTGCTAGAGTTCTGTC; TGGACTTTCCAGAGACCAGTATTCCCTTTTGCTGCCTCTAAAAGGCCTGTCCCTGCAGAC; ATGAGAGACAGCAGGTCTCATGGGGGTGACAAGCTTTTTTTTTTTTCTTAAAGAATTTTC; AAAATCAAATTCCAGAATGATTTTACGGAGATATCCCAGGAAAATTAAGGCTTCTCTTAA; ACACTAAAAAGGCATGTAATTGCTTGTTAGCAAAATGGATATGACACATCTCTGATACTT; TTTTCATTATTGGTTGGGCTGAGCAGTCAGAAGACCTGGTCGTCGTCTTGACTTTGGCAA; ATGAGCCGGAGCCCCTTGGGCAGGTCACACAACCTGTCCCAGCGAGGGACACCGAGTGGC; CCTTCATGTACATCCATGGTGTGCTGGCTTAAAATGTAATTAATCTTGTAAATATACTCC; TAGTAATTTAAGATTTTGTTTTTAAACTGGAAATAAAAGATTGTATAGTGCATGTTTTTT; AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA;
• Restriction Sites: Please inquire
• ACCN: NM_005534
• Insert Size: 1700 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: no
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_005534.2, NP_005525.2
• RefSeq Size: 2219 bp
• RefSeq ORF: 1014 bp
• Locus ID: 3460
• UniProt ID: P38484
• Cytogenetics: 21q22.11
• Domains: FN3
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Natural killer cell mediated cytotoxicity
• Summary: This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. [provided by RefSeq, Jul 2008]