Sulfatase 2 (SULF2) (NM_018837) Human Untagged Clone

SKU SC310069

SULF2 (untagged)-Human sulfatase 2 (SULF2), transcript variant 1

Product Data

• Type: Human Untagged Clone
• Target Symbol: Sulfatase 2
• Synonyms: HSULF-2
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_018837 edited; CAGCAAAAAAAGAAGATGGGCCCCCCGAGCCTCGTGCTGTGCTTGCTGTCCGCAACTGTG; TTCTCCCTGCTGGGTGGAAGCTCGGCCTTCCTGTCGCACCACCGCCTGAAAGGCAGGTTT; CAGAGGGACCGCAGGAACATCCGCCCCAACATCATCCTGGTGCTGACGGACGACCAGGAT; GTGGAGCTGGGTTCCATGCAGGTGATGAACAAGACCCGGCGCATCATGGAGCAGGGCGGG; GCGCACTTCATCAACGCCTTCGTGACCACACCCATGTGCTGCCCCTCACGCTCCTCCATC; CTCACCGGCAAGTACGTCCACAACCACAACACCTACACCAACAATGAGAACTGCTCCTCG; CCCTCCTGGCAGGCACAGCACGAGAGCCGCACCTTTGCCGTGTACCTCAATAGCACTGGC; TACCGGACAGCTTTCTTCGGGAAGTATCTTAATGAATACAACGGCTCCTACGTGCCACCC; GGCTGGAAGGAGTGGGTCGGACTCCTTAAAAACTCCCGCTTTTATAACTACACGCTGTGT; CGGAACGGGGTGAAAGAGAAGCACGGCTCCGACTACTCCAAGGATTACCTCACAGACCTC; ATCACCAATGACAGCGTGAGCTTCTTCCGCACGTCCAAGAAGATGTACCCGCACAGGCCA; GTCCTCATGGTCATCAGCCATGCAGCCCCCCACGGCCCTGAGGATTCAGCCCCACAATAT; TCACGCCTCTTCCCAAACGCATCTCAGCACATCACGCCGAGCTACAACTACGCGCCCAAC; CCGGACAAACACTGGATCATGCGCTACACGGGGCCCATGAAGCCCATCCACATGGAATTC; ACCAACATGCTCCAGCGGAAGCGCTTGCAGACCCTCATGTCGGTGGACGACTCCATGGAG; ACGATTTACAACATGCTGGTTGAGACGGGCGAGCTGGACAACACGTACATCGTATACACC; GCCGACCACGGTTACCACATCGGCCAGTTTGGCCTGGTGAAAGGGAAATCCATGCCATAT; GAGTTTGACATCAGGGTCCCGTTCTACGTGAGGGGCCCCAACGTGGAAGCCGGCTGTCTG; AATCCCCACATCGTCCTCAACATTGACCTGGCCCCCACCATCCTGGACATTGCAGGCCTG; GACATACCTGCGGATATGGACGGGAAATCCATCCTCAAGCTGCTGGACACGGAGCGGCCG; GTGAATCGGTTTCACTTGAAAAAGAAGATGAGGGTCTGGCGGGACTCCTTCTTGGTGGAG; AGAGGCAAGCTGCTACACAAGAGAGACAATGACAAGGTGGACGCCCAGGAGGAGAACTTT; CTGCCCAAGTACCAGCGTGTGAAGGACCTGTGTCAGCGTGCTGAGTACCAGACGGCGTGT; GAGCAGCTGGGACAGAAGTGGCAGTGTGTGGAGGACGCCACGGGGAAGCTGAAGCTGCAT; AAGTGCAAGGGCCCCATGCGGCTGGGCGGCAGCAGAGCCCTCTCCAACCTCGTGCCCAAG; TACTACGGGCAGGGCAGCGAGGCCTGCACCTGTGACAGCGGGGACTACAAGCTCAGCCTG; GCCGGACGCCGGAAAAAACTCTTCAAGAAGAAGTACAAGGCCAGCTATGTCCGCAGTCGC; TCCATCCGCTCAGTGGCCATCGAGGTGGACGGCAGGGTGTACCACGTAGGCCTGGGTGAT; GCCGCCCAGCCCCGAAACCTCACCAAGCGGCACTGGCCAGGGGCCCCTGAGGACCAAGAT; GACAAGGATGGTGGGGACTTCAGTGGCACTGGAGGCCTTCCCGACTACTCAGCCGCCAAC; CCCATTAAAGTGACACATCGGTGCTACATCCTAGAGAACGACACAGTCCAGTGTGACCTG; GACCTGTACAAGTCCCTGCAGGCCTGGAAAGACCACAAGCTGCACATCGACCACGAGATT; GAAACCCTGCAGAACAAAATTAAGAACCTGAGGGAAGTCCGAGGTCACCTGAAGAAAAAG; CGGCCAGAAGAATGTGACTGTCACAAAATCAGCTACCACACCCAGCACAAAGGCCGCCTC; AAGCACAGAGGCTCCAGTCTGCATCCTTTCAGGAAGGGCCTGCAAGAGAAGGACAAGGTG; TGGCTGTTGCGGGAGCAGAAGCGCAAGAAGAAACTCCGCAAGCTGCTCAAGCGCCTGCAG; AACAACGACACGTGCAGCATGCCAGGCCTCACGTGCTTCACCCACGACAACCAGCACTGG; CAGACGGCGCCTTTCTGGACACTGGGGCCTTTCTGTGCCTGCACCAGCGCCAACAATAAC; ACGTACTGGTGCATGAGGACCATCAATGAGACTCACAATTTCCTCTTCTGTGAATTTGCA; ACTGGCTTCCTAGAGTACTTTGATCTCAACACAGACCCCTACCAGCTGATGAATGCAGTG; AACACACTGGACAGGGATGTCCTCAACCAGCTACACGTACAGCTCATGGAGCTGAGGAGC; TGCAAGGGTTACAAGCAGTGTAACCCCCGGACTCGAAACATGGACCTGGGACTTAAAGAT; GGAGGAAGCTATGAGCAATACAGGCAGTTTCAGCGTCGAAAGTGGCCAGAAATGAAGAGA; CCTTCTTCCAAATCACTGGGACAACTGTGGGAAGGCTGGGAAGGTTAAGAAACAACAGAG; GTGGACCTCCAAAAACATAGAGGCATCACCTGACTGCACAGGCAATGAAAAACCATGTGG; GTGATTTCCAGCAGACCTGTGCTATTGGCCAGGAGGCCTGAGAAAGCAAGCACGCACTCT; CAGTCAACATGACAGATTCTGGAGGATAACCAGCAGGAGCAGAGATAACTTCAGGAAGTC; CATTTTTGCCCCTGCTTTTGCTTTGGATTATACCTCACCAGCTGCACAAAATGCATTTTT; TCGTATCAAAAAGTCACCACTAACCCTCCCCCAGAAGCTCACAAAGGAAAACGGAGAGAG; CGAGCGAGAGAGATTTCCTTGGAAATTTCTCCCAAGGGCGAAAGTCATTGGAATTTTTAA; ATCATAGGGGAAAAGCAGTCCTGTTCTAAATCCTCTTATTCTTTTGGTTTGTCACAAAGA; AGGAACTAAGAAGCAGGACAGAGGCAACGTGGAGAGGCTGAAAACAGTGCAGAGACGTTT; GACAATGAGTCAGTAGCACAAAAGAGATGACATTTACCTAGCACTATAAACCCTGGTTGC; CTTTGAAGAAACTGCCTTCATTGTATATATGTGACTATTTACATGTAATCAACATGGGAA; CTTTTAGGGGAACCTAATAAGAAATCCCAATTTTCAGGAGTGGTGGTGTCAATAAACGCT; CTGTGGCCAGTGTAAAAGAAAAAAAAAAAAAAAAAAAAAAAAAA;
• Restriction Sites: Please inquire
• ACCN: NM_018837
• Insert Size: 3300 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The ORF of this clone has been fully sequenced and found to be a perfect match to NM_018837.2.
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_018837.2, NP_061325.1
• RefSeq Size: 3897 bp
• RefSeq ORF: 2613 bp
• Locus ID: 55959
• UniProt ID: Q8IWU5
• Cytogenetics: 20q13.12
• Protein Families: Druggable Genome, Transmembrane
• Summary: Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]; Transcript Variant: This variant (1) encodes the longer isoform (a). Both variants 1 and 3 encode the same isoform.