GABA A Receptor gamma 2 (GABRG2) (NM_198904) Human Untagged Clone

SKU SC307809

GABRG2 (untagged)-Human gamma-aminobutyric acid (GABA) A receptor, gamma 2 (GABRG2), transcript variant 1

Product Data

• Type: Human Untagged Clone
• Target Symbol: GABA A Receptor gamma 2
• Synonyms: CAE2; DEE74; ECA2; EIEE74; FEB8; GEFSP3
• Vector: PCMV6-Neo
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_198904 edited; TCTGCCCCCTGAATATTAATTCCCTAATCTGGTAGCAATCCATCTCCCCAGTGAAGGACC; TACTAGAGGCAGGTGGGGGGAGCCACCATCAGATCATAAGCATAAGAATAATACAAAGGG; GAGGGATTCTTCTGCAACCAAGAGGCAAGAGGCGAGAGAAGGAAAAAAAAAAAAGCGATG; AGTTCGCCAAATATATGGAGCACAGGAAGCTCAGTCTACTCGACTCCTGTATTTTCACAG; AAAATGACGGTGTGGATTCTGCTCCTGCTGTCGCTCTACCCTGGCTTCACTAGCCAGAAA; TCTGATGATGACTATGAAGATTATGCTTCTAACAAAACATGGGTCTTGACTCCAAAAGTT; CCTGAGGGTGATGTCACTGTCATCTTAAACAACCTGCTGGAAGGATATGACAATAAACTT; CGGCCTGATATAGGAGTGAAGCCAACGTTAATTCACACAGACATGTATGTGAATAGCATT; GGTCCAGTGAACGCTATCAATATGGAATACACTATTGATATATTTTTTGCGCAAACGTGG; TATGACAGACGTTTGAAATTTAACAGCACCATTAAAGTCCTCCGATTGAACAGCAACATG; GTGGGGAAAATCTGGATTCCAGACACTTTCTTCAGAAATTCCAAAAAAGCTGATGCACAC; TGGATCACCACCCCCAACAGGATGCTGAGAATTTGGAATGATGGTCGAGTGCTCTACACC; CTAAGGTTGACAATTGATGCTGAGTGCCAATTACAATTGCACAACTTTCCAATGGATGAA; CACTCCTGCCCCTTGGAGTTCTCAAGTTATGGCTATCCACGTGAAGAAATTGTTTATCAA; TGGAAGCGAAGTTCTGTTGAAGTGGGCGACACAAGATCCTGGAGGCTTTATCAATTCTCA; TTTGTTGGTCTAAGAAATACCACCGAAGTAGTGAAGACAACTTCCGGAGATTATGTGGTC; ATGTCTGTCTACTTTGATCTGAGCAGAAGAATGGGATACTTTACCATCCAGACCTATATC; CCCTGCACACTCATTGTCGTCCTATCCTGGGTGTCTTTCTGGATCAATAAGGATGCTGTT; CCAGCCAGAACATCTTTAGGTATCACCACTGTCCTGACAATGACCACCCTCAGCACCATT; GCCCGGAAATCGCTCCCCAAGGTCTCCTATGTCACAGCGATGGATCTCTTTGTATCTGTT; TGTTTCATCTTTGTCTTCTCTGCTCTGGTGGAGTATGGCACCTTGCGTTATTTTGTCAGC; AACCGGAAACCAAGCAAGGACAAAGATAAAAAGAAGAAAAACCCTCTTCTTCGGATGTTT; TCCTTCAAGGCCCCTACCATTGATATCCGCCCAAGATCAGCAACCATTCAAATGAATAAT; GCTACACACCTTCAAGAGAGAGATGAAGAGTACGGCTATGAGTGTCTGGACGGCAAGGAC; TGTGCCAGTTTTTTCTGCTGTTTTGAAGATTGTCGAACAGGAGCTTGGAGACATGGGAGG; ATACATATCCGCATTGCCAAAATGGACTCCTATGCTCGGATCTTCTTCCCCACTGCCTTC; TGCCTGTTTAATCTGGTCTATTGGGTCTCCTACCTCTACCTGTGAGGAGGTATGGGTTTT; ACTGATATGGTTCTTATTCACTGAGTCTCATGGAGAGATGTCTGTTCTAAGTCCACTTAA; ATAATCCTCTATGTGGTTGATAATGATCTGAATCTGTTTCTATGTCCAAACCTGGTAAAT; TTTATAATGTCATATTGTTTGTGCCAAGCCCTCCTTTGGTTAGTGTACTTTGAACTTCGA; TGTTTGCTGTGTTTCAAACCTGCAAGGCAAAGTAAAATTAGAGCAAGAACATTCAAACCA; AATAAGATATTTTTCAGCTACAGCAAATAAAACAGTGAAAGCCCTGACTATTTACAGTAG; TGGTATCCTTACTAGATTCATAATGCAATTAGATAGAAAAGGTCCAAAACTGTACCCTAT; GTTCACTCCGGGTCAAGTTGTGATAAATTTGATCCCAATAGAATACCTCCCTCATTTAAG; AAAAATCATAACTCACTTTAAATATGAAAGCCTAGTCCAGAAATCTATTACACCTTTATC; TCAAGATAGGAAGAAAATTTCCTCCACATTCATGTACAATGATGTAAATATTTCAATAAC; TTAGAATGCTTCAAGTTTAGTGCATGCATCTCTTTAGATCCAAAATAAATGGACTGAAGT; TATCATCCTATTGTCTTTTATTTTGTGTCCTTGGGCTATAAAAGATTCCTGAATGTAATT; ATAAGGATTTGGGTTTGGAAATGGAGGGAGGAATTTTCATTGCCTTCTCCCTCATGCATG; AAGATTCGAACAGCTTATTTTTTCCTTGTATGACATATTACAACACTTTAAGTAAAATAT; AGACTGGATAATCAACATTTGCCACCTCTAAATATGCCCAATTTCATAACTAGAGTATAA; AGTAATCGTATGTGCTTGCCGCTATTTTTTTCTTCCTTTTAGGATGATAGATCATAACAG; AACTTATTCTCCATCTCAAGATCTGCTTCTAGTGATTGTGAGTGCCTTGTGGGCAGAATC; CTTGTCATTTCCTCTTTGGGTCTGTAGCACCTTGCATAGTGCCTGGCATATAGTTGGTGC; TCAATAAATATGGTTTGAAGTGAATTGCCCTCACATGCTTCTGGCAAATCTCTGTGCTGG; CCTGAAACCAGTGACTCATCTTCTCACATAGGTGTTGTCAAGTGATATTTGATTTTGTAA; AAATAACCAGTAGGATCCAAAGAACTTTAGCTATTTATGTTCATCTTCAAAAAATTATTT; TAGGCAAAGTCCATACTCCTTTTAAAACAATATTTATGTCCTATGTTTGTGTATAGACAT; GACTCTACTAGGGCATAATTAGAGTTTGTGTATTATTTTTCCAGGTTTGGGGATGAGTCA; GTCCTTGCCCATCCACAATTTTGTTTGTGAACTTATAACAGGAATAAGCAAAATTCATAC; CTGACTAGTGTTCAGAATGTAGCATTCTGTGCGAAAAAGTATTGAAGATTAGCTTTTAAA; AACTGAAAAAAAAAAATGAATGACTCACATAGAGGTTGAGCCAATGACTGTGGCCTCATT; AGATTACATTGTAGTTAAACAAAGCAATTTCTCCAGACTTAAAACATGATGAGTTGAGCT; CTATCTTCATGTACTCATCCTGAATCCTTATTTTTCTAAAATAGCACCCTTTGTTAATTA; TTTTTATGGAAATTATTACTCTGTCATAATTAAATCATAGCTAGTATAACTTTACAGATA; ACCTAAAAAGAATAGAAAAGAAGAGAGAGTGGCTTTGTCAGTATAAAACCATGTAAAGTC; ATCATCAAGTCATCTGGATGAATCTTGAAACACATTTAGCTGCCAGTTTTACAAACCTTT; AATATATCAGTGCTCCAGTATATAACCTCAAACAAATGTAAATAGAACGAATTATTTTCT; TGTTTTGAATTGTCAATATATTAAATGTTGACTCTTTGGGAGAGTTGTTGGCAAGTTTCA; ATGGTGAGAAACATTATTGTCAACTTGAAATGTGTTCTGTAATGGGGACACTACAAAAAG; CTAGCTTTCCAATGTGTGCATAGTATTGGCAATATGAATATATATTATATATAATCTAAT; ACTTATTATAAGCTGCTCCCTGTCTATGTATTTGGAAACCTTTTCACAAAGGGAATTGCC; TAACATGTGGACTTTTACAATAAAAATGCTGCATTCTAAAAAAAAAAAAAAA;
• Restriction Sites: Please inquire
• ACCN: NM_198904
• Insert Size: 3800 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The ORF of this clone has been fully sequenced and found to contain one SNP compared with NM_198904.1.
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_198904.1, NP_944494.1
• RefSeq Size: 3871 bp
• RefSeq ORF: 1428 bp
• Locus ID: 2566
• UniProt ID: P18507
• Cytogenetics: 5q34
• Protein Families: Druggable Genome, Ion Channels: Cys-loop Receptors, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction
• Summary: This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammlian brain, where it acts at GABA-A receptors, which are ligand-gated chloride channels. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene have been associated with epilepsy and febrile seizures. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]; Transcript Variant: This variant (1) lacks an alternate in-frame exon, compared to variant 3. It encodes isoform 1 which is shorter than isoform 3.