IL22 RA2 (IL22RA2) (NM_181309) Human Untagged Clone

SKU SC307270

IL22RA2 (untagged)-Human interleukin 22 receptor, alpha 2 (IL22RA2), transcript variant 2

Product Data

• Type: Human Untagged Clone
• Target Symbol: IL22 RA2
• Synonyms: CRF2-10; CRF2-S1; CRF2X; IL-22BP; IL-22R-alpha-2; IL-22RA2; ZCYTOR16
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_181309 edited; TTTCCTCTTTGGTCCTGAGCTGGTTAAAAGGAACACTGGTTGCCTGAACAGTCACACTTG; CAACCATGATGCCTAAACATTGCTTTCTAGGCTTCCTCATCAGTTTCTTCCTTACTGGTG; TAGCAGGAACTCAGTCAACGCATGAGTCTCTGAAGCCTCAGAGGGTACAATTTCAGTCCC; GAAATTTTCACAACATTTTGCAATGGCAGCCTGGGAGGGCACTTACTGGCAACAGCAGTG; TCTATTTTGTGCAGTACAAAATATATGGACAGAGACAATGGAAAAATAAAGAAGACTGTT; GGGGTACTCAAGAACTCTCTTGTGACCTTACCAGTGAAACCTCAGACATACAGGAACCTT; ATTACGGGAGGGTGAGGGCGGCCTCGGCTGGGAGCTACTCAGAATGGAGCATGACGCCGC; GGTTCACTCCCTGGTGGGAAACAAAAATAGATCCTCCAGTCATGAATATAACCCAAGTCA; ATGGCTCTTTGTTGGTAATTCTCCATGCTCCAAATTTACCATATAGATACCAAAAGGAAA; AAAATGTATCTATAGAAGATTACTATGAACTACTATACCGAGTTTTTATAATTAACAATT; CACTAGAAAAGGAGCAAAAGGTTTATGAAGGGGCTCACAGAGCGGTTGAAATTGAAGCTC; TAACACCACACTCCAGCTACTGTGTAGTGGCTGAAATATATCAGCCCATGTTAGACAGAA; GAAGTCAGAGAAGTGAAGAGAGATGTGTGGAAATTCCATGACTTGTGGAATTTGGCATTC; AGCAATGTGGAAATTCTAAAGCTCCCTGAGAACAGGATGACTCGTGTTTGAAGGATCTTA; TTTAAAATTGTTTTTGTATTTTCTTAAAGCAATATTCACTGTTACACCTTGGGGACTTCT; TTGTTTATCCATTCTTTTATCCTTTATATTTCATTTGTAAACTATATTTGAACGACATTC; CCCCCGAAAAATTGAAATGTAAAGATGAGGCAGAGAATAAAGTGTTCTATGAAATTCAGA; ACTTTATTTCTGAATGTAACATCCCTAATAACAACCTTCATTCTTCTAATACAGCAAAAT; AAAAATTTAACAACCAAGGAATAGTATTTAAGAAAATGTTGAAATAATTTTTTTAAAATA; GCATTACAGACTGAGGCGGTCCTGAAGCAATGGTTTTTCACTCTCTTATTGAGCCAATTA; AATTGACATTGCTTTGACAATTTAAAACTTCTATAAAGGTGAATATTTTTCATACATTTC; TATTTTATATGAATATACTTTTTATATATTTATTATTATTAAATATTTCTACTTAATGAA; TCAAAATTTTGTTTTAAAGTCTACTTTATGTAAATAAGAACAGGTTTTGGGGAAAAAAAT; CTTATGATTTCTGGATTGATATCTGAATTAAAACTATCAACAACAAGGAAGTCTACTCTG; TACAATTGTCCCTCATTTAAAAGATATATTAAGCTTTTCTTTTCTGTTTGTTTTTGTTTT; GTTTAGTTTTTAATCCTGTCTTAGAAGAACTTATCTTTATTCTCAAAATTAAATGTAATT; TTTTTAGTGACAAAGAAGAAAGGAAACCTCATTACTCAATCCTTCTGGCCAAGAGTGTCT; TGCTTGTGGCGC;
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_181309 unedited; TTTTGTAATACGACTCACTATAGGGCGGCCGCGAATTCGCCCTTTCCTCTTTGGTCCTGA; GCTGGTTAAAAGGAACACTGGTTGCCTGAACAGTCACACTTGCAACCATGATGCCTAAAC; ATTGCTTTCTAGGCTTCCTCATCAGTTTCTTCCTTACTGGTGTAGCAGGAACTCAGTCAA; CGCATGAGTCTCTGAAGCCTCAGAGGGTACAATTTCAGTCCCGAAATTTTCACAACATTT; TGCAATGGCAGCCTGGGAGGGCACTTACTGGCAACAGCAGTGTCTATTTTGTGCAGTACA; AAATATATGGACAGAGACAATGGAAAAATAAAGAAGACTGTTGGGGTACTCAAGAACTCT; CTTGTGACCTTACCAGTGAAACCTCAGACATACAGGAACCTTATTACGGGAGGGTGAGGG; CGGCCTCGGCTGGGAGCTACTCAGAATGGAGCATGACGCCGCGGTTCACTCCCTGGTGGG; AAACAAAAATAGATCCTCCAGTCATGAATATAACCCAAGTCAATGGCTCTTTGTTGGTAA; TTCTCCATGCTCCAAATTTACCATATAGATACCAAAAGGAAAAAAATGTATCTATAGAAG; ATTACTATGAACTACTATACCGAGTTTTTATAATTAACAATTCACTAGAAAAGGAGCANA; AGGGTTATGAAGGGGCTCACAGAGCGGTTGAAATTGAAGCTCTAACACCACACTCCAGCT; ACTGTGTAGTGGCTGAAATATATCAGCCCATGTTAGACAGAAGAAGTCAGAGAAGTGAAG; AGAGATGTGTGGAAAATTCATTGACTGTGGGAATTGGCATTCAGCATGGTGGAATTCTAA; AGCTCCCTGANAACAAGATGA;
• Restriction Sites: Please inquire
• ACCN: NM_181309
• Insert Size: 1600 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_181309.1, NP_851826.1
• RefSeq Size: 2814 bp
• RefSeq ORF: 696 bp
• Locus ID: 116379
• UniProt ID: Q969J5
• Cytogenetics: 6q23.3
• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway
• Summary: This gene encodes a member of the class II cytokine receptor family. The encoded soluble protein specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor. The encoded protein may be important in the regulation of inflammatory response, and has been implicated in the regulation of tumorigenesis in the colon. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2013]; Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) is shorter, compared to isoform 1.