IL23 Receptor (IL23R) (NM_144701) Human Untagged Clone

SKU SC306188

IL23R (untagged)-Human interleukin 23 receptor (IL23R)

Product Data

• Type: Human Untagged Clone
• Target Symbol: IL23 Receptor
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_144701, RT-PCR generated; CTTTTCCTGCTTCCAGACATGAATCATGTCACTATTCAATGGGATGCAGTAATAGCCCTT; TACATACTCTTCAGCTGGTGTCATGGAGGAATTACAAATATAAACTGCTCTGGCCACATC; TGGGTAGAACCAGCCACAATTTTTAAGATGGGTATGAATATCTCTATATATTGCCAAGCA; GCAATTAAGAACTGCCAACCAAGGAAACTTCATTTTTATAAAAATGGCATCAAAGAAAGA; TTTCAAATCACAAGGATTAATAAAACAACAGCTCGGCTTTGGTATAAAAACTTTCTGGAA; CCACATGCTTCTATGTACTGCACTGCTGAATGTCCCAAACATTTTCAAGAGACACTGATA; TGTGGAAAAGACATTTCTTCTGGATATCCGCCAGATATTCCTGATGAAGTAACCTGTGTC; ATTTATGAATATTCAGGCAACATGACTTGCACCTGGAATGCTGGGAAGCTCACCTACATA; GACACAAAATACGTGGTACATGTGAAGAGTTTAGAGACAGAAGAAGAGCAACAGTATCTC; ACCTCAAGCTATATTAACATCTCCACTGATTCATTACAAGGTGGCAAGAAGTACTTGGTT; TGGGTCCAAGCAGCAAACGCACTAGGCATGGAAGAGTCAAAACAACTGCAAATTCACCTG; GATGATATAGTGATACCTTCTGCAGCCGTCATTTCCAGGGCTGAGACTATAAATGCTACA; GTGCCCAAGACCATAATTTATTGGGATAGTCAAACAACAATTGAAAAGGTTTCCTGTGAA; ATGAGATACAAGGCTACAACAAACCAAACTTGGAATGTTAAAGAATTTGACACCAATTTT; ACATATGTGCAACAGTCAGAATTCTACTTGGAGCCAAACATTAAGTACGTATTTCAAGTG; AGATGTCAAGAAACAGGCAAAAGGTACTGGCAGCCTTGGAGTTCACCGTTTTTTCATAAA; ACACCTGAAACAGTTCCCCAGGTCACATCAAAAGCATTCCAACATGACACATGGAATTCT; GGGCTAACAGTTGCTTCCATCTCTACAGGGCACCTTACTTCTGACAACAGAGGAGACATT; GGACTTTTATTGGGAATGATCGTCTTTGCTGTTATGTTGTCAATTCTTTCTTTGATTGGG; ATATTTAACAGATCATTCCGAACTGGGATTAAAAGAAGGATCTTATTGTTAATACCAAAG; TGGCTTTATGAAGATATTCCTAATATGAAAAACAGCAATGTTGTGAAAATGCTACAGGAA; AATAGTGAACTTATGAATAATAATTCCAGTGAGCAGGTCCTATATGTTGATCCCATGATT; ACAGAGATAAAAGAAATCTTCATCCCAGAACACAAGCCTACAGACTACAAGAAGGAGAAT; ACAGGACCCCTGGAGACAAGAGACTACCCGCAAAACTCGCTATTCGACAATACTACAGTT; GTATATATTCCTGATCTCAACACTGGATATAAACCCCAAATTTCAAATTTTCTGCCTGAG; GGAAGCCATCTCAGCAATAATAATGAAATTACTTCCTTAACACTTAAACCACCAGTTGAT; TCCTTAGACTCAGGAAATAATCCCAGGTTACAAAAGCATCCTAATTTTGCTTTTTCTGTT; TCAAGTGTGAATTCACTAAGCAACACAATATTTCTTGGAGAATTAAGCCTCATATTAAAT; CAAGGAGAATGCAGTTCTCCTGACATACAAAACTCAGTAGAGGAGGAAACCACCATGCTT; TTGGAAAATGATTCACCCAGTGAAACTATTCCAGAACAGACCCTGCTTCCTGATGAATTT; GTCTCCTGTTTGGGGATCGTGAATGAGGAGTTGCCATCTATTAATACTTATTTTCCACAA; AATATTTTGGAAAGCCACTTCAATAGGATTTCACTCTTGGAAAAGTAGAGCTGTGTGGTC; AAAATCAATATGAGAAAGCTGCCTTGCAA;
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_144701 unedited; GGGACGTCAAAAATTGTATACGACTCACTATAGGCGGCCGCGNAATCAAATCTGGTACCG; ATATCAAGCTTGGTACCGAGCTCGNGACCACTAGTAACGGCCGCCAGTGTGCTGGAATTC; GCCCTTGAGGGTACCTTTTCCTGCTTCCAGACATGAATCATGTCACTATTCAATGGGATG; CAGTAATAGCCCTTTACATACTCTTCAGCTGGTGTCATGGAGGAATTACAAATATAAACT; GCTCTGGCCACATCTGGGTAGAACCAGCCACAATTTTTAAGATGGGTATGAATATCTCTA; TATATTGCCAAGCAGCAATTAAGAACTGCCAACCAAGGAAACTTCATTTTTATAAAAATG; GCATCAAAGAAAGATTTCAAATCACAAGGATTAATAAAACAACAGCTCGGCTTTGGTATA; AAAACTTTCTGGAACCACATGCTTCTATGTACTGCACTGCTGAATGTCCCAAACATTTTC; AAGAGACACTGATATGTGGAAAAGACATTTCTTCTGGATATCCGCCAGATATTCCTGATG; AAGTAACCTGTGTCATTTATGAATATTCAGGCAACATGACTTGCACCTGGAATGCTGGGA; AGCTCACCTACATAGACACAAAATACGTGGTACATGTNGAAGAGTTTAGAGACAGAAGAA; GAGCAACAGTATCTCACCTCAAGCTATATTAACATCTCCACTGATTCATTACAAGGTGGC; AAGAGTTACTTTGGTTTTGGGTCCAAGCAGCAAACGCACTNAGNATGGGAAGAGTCAAAA; CAACTGCAAATTACCCTGGATGATATAGTGATACCTTCTGCAGCCGTCATTTCCAGGGCT; GAGACTATAATGGCTACAGTGCCCAAGACCATNATTTATTGGGGATA;
• Restriction Sites: Please inquire
• ACCN: NM_144701
• Insert Size: 1500 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: This construct is a cloned PCR fragment that was fully sequenced. While there are 2 nucleotide differences between the OriGene clone and the NCBI reference ORF, these differences are supported by other cDNA references within Genbank. OriGene considers these to be polymorphisms and to reflect the natural differences between individuals. These result in the substitution of 2 amino acids.
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_144701.2, NP_653302.2
• RefSeq Size: 2826 bp
• RefSeq ORF: 1890 bp
• Locus ID: 149233
• UniProt ID: Q5VWK5
• Cytogenetics: 1p31.3
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway
• Summary: The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq, Jul 2008]