GAB2 (NM_080491) Human Untagged Clone

CAT#: SC305788

GAB2 (untagged)-Human GRB2-associated binding protein 2 (GAB2), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: GAB2
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC305788 sequence for NM_080491 edited (data generated by NextGen Sequencing)
  ATGAGCGGCGGCGGCGACGTGGTGTGCACCGGCTGGCTGAGGAAATCGCCTCCCGAGAAG
  AAGTTGAGGCGCTATGCCTGGAAGAAACGCTGGTTTATCCTGCGGAGTGGCCGGATGAGC
  GGTGACCCAGATGTTCTGGAATACTACAAGAACGATCACTCCAAGAAGCCTCTGCGGATC
  ATCAACCTGAACTTCTGTGAGCAGGTAGATGCAGGCCTGACCTTTAACAAGAAGGAGCTG
  CAGGATAGTTTTGTGTTTGACATCAAGACCAGTGAACGCACCTTTTACCTGGTGGCTGAG
  ACAGAAGAGGACATGAATAAGTGGGTCCAGAGCATCTGCCAGATCTGTGGCTTCAATCAG
  GCTGAGGAGAGCACAGACTCCCTGAGAAATGTTTCCTCAGCCGGTCATGGCCCCCGCTCT
  TCTCCAGCTGAGCTCAGCAGCTCTAGCCAGCACCTTCTCCGAGAGCGCAAGTCCTCAGCC
  CCATCACACTCCAGCCAGCCAACTCTGTTCACGTTTGAACCCCCTGTGTCAAACCACATG
  CAGCCCACCTTGTCCACCAGCGCACCTCAGGAGTATCTCTACTTGCACCAGTGCATAAGC
  CGAAGAGCAGAAAATGCAAGGAGTGCCAGCTTCTCTCAGGGCACCAGAGCCTCTTTTCTC
  ATGAGGAGTGACACAGCTGTACAAAAACTTGCCCAGGGCAATGGACACTGTGTCAACGGG
  ATCAGTGGTCAAGTCCATGGCTTCTATAGCCTTCCCAAGCCGAGCCGGCACAATACAGAA
  TTCAGAGACAGTACCTACGACCTCCCCCGCAGCCTGGCCTCCCATGGCCACACCAAGGGC
  AGCCTCACAGGCTCCGAGACAGATAATGAGGATGTGTACACCTTCAAGACGCCCAGCAAC
  ACCCTGTGCAGGGAGTTTGGGGACCTCCTGGTAGACAATATGGATGTTCCGGCCACCCCA
  CTCTCAGCCTACCAGATCCCTAGGACATTCACTCTGGACAAAAACCACAATGCCATGACA
  GTGGCCACTCCTGGGGACTCAGCCATAGCTCCCCCACCCCGCCCCCCCAAGCCAAGTCAG
  GCAGAAACACCTCGATGGGGCAGTCCTCAGCAGAGACCGCCAATCAGTGAAAATAGCAGA
  TCTGTCGCTGCCACCATCCCCAGACGCAACACCCTCCCTGCAATGGACAACAGCCGACTT
  CACCGAGCTTCTTCCTGTGAGACCTACGAGTACCCACAGCGTGGTGGAGAGAGTGCAGGC
  CGGTCTGCTGAATCCATGAGTGATGGAGTCGGCTCTTTCCTGCCAGGGAAAATGATTGTG
  GGCCGATCGGACAGCACCAATTCTGAAGACAACTATGTGCCCATGAATCCAGGTTCTTCC
  ACCCTGTTGGCCATGGAACGAGCAGGTGATAATTCCCAGAGCGTCTACATCCCAATGAGC
  CCAGGGGCCCATCACTTTGACTCACTTGGCTACCCATCAACAACCCTTCCTGTGCACCGA
  GGCCCCAGCAGAGGAAGTGAGATTCAGCCACCCCCTGTCAACCGCAACCTCAAACCTGAT
  CGGAAAGCAAAGCCAACACCACTTGACCTGAGGAACAACACCGTCATCGATGAACTCCCC
  TTCAAGTCACCTATCACCAAGTCTTGGTCTAGGGCCAACCACACCTTCAACTCCAGCTCC
  TCCCAGTACTGCCGCCCCATCTCCACCCAGAGCATCACCAGCACAGACTCAGGAGACAGC
  GAAGAGAACTATGTCCCTATGCAAAACCCAGTGTCTGCATCTCCCGTTCCCAGTGGCACG
  AACAGTCCTGCCCCTAAGAAGAGCACCGGCAGCGTTGATTATCTGGCCCTGGACTTCCAG
  CCGAGCTCCCCAAGCCCCCACCGCAAGCCATCTACTTCATCCGTCACCTCTGATGAGAAG
  GTGGACTACGTTCAGGTGGACAAGGAGAAGACCCAGGCCCTGCAGAACACCATGCAGGAG
  TGGACAGACGTGCGGCAGTCCTCGGAGCCTTCCAAGGGTGCCAAGCTGTGA
  
  Clone variation with respect to NM_080491.2
  918 c=>t;1290 t=>c;2004 a=>g
• Restriction Sites: Please inquire
• ACCN: NM_080491
• Insert Size: 2700 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: There are 4 nucleotide differences between the OriGene clone and the NCBI reference ORF. OriGene considers these to be polymorphisms and to reflect the natural differences between individuals. These
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_080491.1, NP_536739.1
• RefSeq Size: 6007 bp
• RefSeq ORF: 2031 bp
• Locus ID: 9846
• UniProt ID: Q9UQC2
• Cytogenetics: 11q14.1
• Protein Families: Druggable Genome
• Protein Pathways: Chronic myeloid leukemia, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis
• Gene Summary: This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
  Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).