GNA11 (NM_002067) Human Untagged Clone

SKU SC303115

GNA11 (untagged)-Human guanine nucleotide binding protein (G protein), alpha 11 (Gq class) (GNA11)

Product Data

• Type: Human Untagged Clone
• Target Symbol: GNA11
• Synonyms: FBH; FBH2; FHH2; GNA-11; HHC2; HYPOC2
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_002067 edited; ATGACTCTGGAGTCCATGATGGCGTGTTGCCTGAGCGATGAGGTGAAGGAGTCCAAGCGG; ATCAACGCCGAGATCGAGAAGCAGCTGCGGCGGGACAAGCGCGACGCCCGGCGCGAGCTC; AAGCTGCTGCTGCTCGGCACGGGCGAGAGCGGGAAGAGCACGTTCATCAAGCAGATGCGC; ATCATCCACGGCGCCGGCTACTCGGAGGAGGACAAGCGCGGCTTCACCAAGCTCGTCTAC; CAGAACATCTTCACCGCCATGCAGGCCATGATCCGGGCCATGGAGACGCTCAAGATCCTC; TACAAGTACGAGCAGAACAAGGCCAATGCGCTCCTGATCCGGGAGGTGGACGTGGAGAAG; GTGACCACCTTCGAGCATCAGTACGTCAGTGCCATCAAGACCCTGTGGGAGGACCCGGGC; ATCCAGGAATGCTACGACCGCAGGCGCGAGTACCAGCTCTCCGACTCTGCCAAGTACTAC; CTGACCGACGTTGACCGCATCGCCACCTTGGGCTACCTGCCCACCCAGCAGGACGTGCTG; CGGGTCCGCGTGCCCACCACCGGCATCATCGAGTACCCTTTCGACCTGGAGAACATCATC; TTCCGGATGGTGGATGTGGGGGGCCAGCGGTCGGAGCGGAGGAAGTGGATCCACTGCTTT; GAGAACGTGACATCCATCATGTTTCTCGTCGCCCTCAGCGAATACGACCAAGTCCTGGTG; GAGTCGGACAACGAGAACCGGATGGAGGAGAGCAAAGCCCTGTTCCGGACTATCATCACC; TACCCCTGGTTCCAGAACTCCTCCGTCATCCTCTTCCTCAACAAGAAGGACCTGCTGGAG; GACAAGATCCTGTACTCGCACCTGGTGGACTACTTCCCCGAGTTCGATGGTCCCCAGCGG; GACGCCCAGGCGGCGCGGGAGTTCATCCTGAAGATGTTCGTGGACCTGAACCCCGACAGC; GACAAGATCATCTACTCACACTTCACGTGTGCCACCGACACGGAGAACATCCGCTTCGTG; TTCGCGGCCGTGAAGGACACCATCCTGCAGCTCAACCTCAAGGAGTACAACCTGGTCTGA; GCGCCCAGGCCCAGGGAGACGGGATGGAGACACGGGGCAGGACCTTCCTTCCACGGAGCC; TGCGGCTGCCGGGCGGGTGGCGCTGCCGAGTCCGGGCCGGGGCCTCTGCCCGCGGGAGGA; GATTTTTTTTTTTCATATTTTTAACAAATGGTTTTTATTTCACAGTTATCAGGGGATGTA; CATCTCTCCCTCCGTACACTTCGCGCACCTTCTCACCTTTTGTCAACGGCAAAGGCAGCC; TTTTTCTGGCCTTGACTTATGGCTCGCTTTTTTCTAAAAAAAAAAAAAAAAAA;
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_002067 unedited; GTCAAAATTTGTATACGACTCATATAGGCGGCCGCGNAATTCGCACGAGGATGACTCTGG; AGTCCATGATGGCGTGTTGCCTGAGCGATGAGGTGAAGGAGTCCAAGCGGATCAACGCCG; AGATCGAGAAGCAGCTGCGGCGGGACAAGCGCGACGCCCGGCGCGAGCTCAAGCTGCTGC; TGCTCGGCACGGGCGAGAGCGGGAAGAGCACGTTCATCAAGCAGATGCGCATCATCCACG; GCGCCGGCTACTCGGAGGAGGACAAGCGCGGCTTCACCAAGCTCGTCTACCAGAACATCT; TCACCGCCATGCAGGCCATGATCCGGGCCATGGAGACGCTCAAGATCCTCTACAAGTACG; AGCAGAACAAGGCCAATGCGCTCCTGATCCGGGAGGTGGACGTGGAGAAGGTGACCACCT; TCGAGCATCAGTACGTCAGTGCCATCAAGACCCTGTGGGAGGACCCGGGCATCCAGGAAT; GCTACGACCGCAGGCGCGAGTACCAGCTCTCCGACTCTGCCAAGTACTACCTGACCGACG; TTGACCGCATCGCCACCTTGGGCTACCTGCCCACCCAGCAGGACGTGCTGCGGGTCCGCG; TGCCCACCACCGGCATCATCGAGTACCCTTTCGACCTGGAGAACATCATCTTCCGGATGG; TGGATGTGGGGGGCCAGCGGTCGGAGCGGAGGAAGTGGATCCACTGCTTTGAGAACGTGA; CATCCATCATGTTTCTCGTCGCCCTCAGCGAATACGACCAAGTCCTGGTGGAGTCNGACA; ACGAGAACCGGATGGGAGGAGAGCAAGCCCTGTTCCGGACTATCATCACCTACCCCTGGT; TCCAGAACTNCTNCGTCATCCTCTTTCTCAACAGAAGGACCTGCTGNAGGACAGATCCTG; TACTCGCACN;
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_002067 unedited; CCCATTGAGATGGCACTTCCAGGTCCAGNAAAGCACTGGGGNAGGGTCACAGGGATGCCA; CCCGGGATCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGAGTCGAGTTTTTTT; TTTTTTTTTTTAGAAAAAAGCGAGCCATAAGTCAAGGCCAGAAAAAGGCTGCCTTTGCCG; TTGACAAAAGGTGAGAAGGTGCGCGAAGTGTACGGAGGGAGAGATGTACATCCCCTGATA; ACTGTGAAATAAAAACCATTTGTTAAAAATATGAAAAAAAAAAATCTCCTCCCGCGGGCA; GAGGCCCCGGCCCGGACTCGGCAGCGCCACCCGCCCGGCAGCCGCAGGCTCCGTGGAAGG; AAGGTCCTGCCCCGTGTCTCCATCCCGTCTCCCTGGGCCTGGGCGCTCAGACCAGGTTGT; ACTCCTTGAGGTTGAGCTGCAGGATGGTGTCCTTCACGGCCGCGAACACGAAGCGGATGT; TCTCCGTGTCGGTGGCACACGTGAAGTGTGAGTAGATGATCTTGTCGCTGTCGGGGTTCA; GGTCCACGAACATCTTCAGGATGAACTCCCGCGCCGCCTGGGCGTCCCGCTGGGGACCAT; CGAACTCGGGGAAGTAGTCCACCAGGTGCGAGTACAGGATCTTGTCCTCCAGCAGGTCCT; TCTTGTTGAGGAAGAGGATGACGGGAGAGTTCTGGAACCAGGGGTAGGTGATGATAGTCC; GGAACAGGGCTTTGCTCTCCTCCATCCGGTTCTCGTTGTCCGACTCCACCAGACTTGGTC; GTATTCGCTGAAGGCGACCAGGAACATGATGGATGTCACGTTCTAAAGCAGGGGATCCAT; TTCTTCGGTTCGACCGTTTGGCCCCCCACTTCACCATTCGGAAGATGTTGTTCTCCAGGT; CGAAAGGTTCTC;
• Restriction Sites: Please inquire
• ACCN: NM_002067
• Insert Size: 1400 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The open reading frame of this TrueClone was fully sequenced and found to be a perfect match to the protein associated to this reference.
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_002067.1, NP_002058.1
• RefSeq Size: 1540 bp
• RefSeq ORF: 1080 bp
• Locus ID: 2767
• UniProt ID: P29992
• Cytogenetics: 19p13.3
• Protein Pathways: Calcium signaling pathway, Gap junction, GnRH signaling pathway, Long-term depression, Vascular smooth muscle contraction
• Summary: The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes one of the alpha subunits (subunit alpha-11). Mutations in this gene have been associated with hypocalciuric hypercalcemia type II (HHC2) and hypocalcemia dominant 2 (HYPOC2). Patients with HHC2 and HYPOC2 exhibit decreased or increased sensitivity, respectively, to changes in extracellular calcium concentrations. [provided by RefSeq, Dec 2013]