CSEN (KCNIP3) (NM_001034914) Human Untagged Clone

SKU SC302812

KCNIP3 (untagged)-Human Kv channel interacting protein 3, calsenilin (KCNIP3), transcript variant 2

Product Data

• Type: Human Untagged Clone
• Target Symbol: CSEN
• Synonyms: CSEN; DREAM; KCHIP3
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_001034914 edited; CTATAGGGCGGCCGCGATGGGCATCCAGGGCATGGAGCTGTGCGCCATGGCCGTGGTGGT; GCTGCTGTTCATCGCCGTCCTCAAGCAGTTCGGCATCCTGGAGCCCATATCCATGGAAGA; TAGCAGCGACAGTGAGCTGGAGCTGTCCACGGTGCGCCACCAGCCAGAGGGGCTGGACCA; GCTGCAGGCCCAGACCAAGTTCACCAAGAAGGAGCTGCAGTCTCTCTACAGGGGCTTTAA; GAATGAGTGTCCCACGGGCCTGGTGGACGAAGACACCTTCAAACTCATTTACGCGCAGTT; CTTCCCTCAGGGAGATGCCACCACCTATGCACACTTCCTCTTCAACGCCTTTGATGCGGA; CGGGAACGGGGCCATCCACTTTGAGGACTTTGTGGTTGGCCTCTCCATCCTGCTGCGGGG; CACAGTCCACGAGAAGCTCAAGTGGGCCTTTAATCTCTACGACATTAACAAGGATGGCTA; CATCACCAAAGAGGAGATGCTGGCCATCATGAAGTCCATCTATGACATGATGGGCCGCCA; CACCTACCCCATCCTGCGGGAGGACGCGCCGGCGGAGCACGTGGAGAGGTTCTTCGAGAA; AATGGACCGGAACCAGGATGGGGTAGTGACCATTGAAGAGTTCCTGGAGGCCTGTCAGAA; GGATGAGAACATCATGAGCTCCATGCAGCTGTTTGAGAATGTCATCTAGGACACGTCCAA; AGGAGTGCATGGCCACAGCCACCTCCACCCCCAAGAAACCTCCATCCTGCCAGGAGCAGC; CTCCAAGAAACTTTTAAAAAATAGATTTGCAAAAAGTGAACAGATTGCTACACACACACA; CACACACACACACACACACACACACACAGCCATTCATCTGGGCTGGCAGAGGGGACAGAG; TTCAGGGAGGGGCTGAGTCTGGCTAGGGGCCGAGTCCAGGAGCCCCAGCCAGCCCTTCCC; AGGCCAGCGAGGCGAGGCTGCCTCTGGGTGAGTGGCTGACAGAGCAGGTCTGCAGGCCAC; CAGCTGCTGGATGTCACCAAGAAGGGGCTCGAGTGCCCCTGCAGGGGAGGGTCCAATCTC; CGGTGTGAGCCCACCTCGTCCCGTTCTCCATTCTGCTTTCTTGCCACACAGTGGGCCGGC; CCCAGGCTCCCCTGGTCTCCTCCCCGTAGCCACTCTCTGCCCACTACCTATGCTTCTAGA; AAGCCCCTCACCTCAGGACCCCAGAGGGACCAGCTGGGGGGCAGGGGGGAGAGGGGGTAA; TGGAGGCCAAGCCTGCAGCTTTCTGGAAATTCTTCCCTGGGGGTCCCAGGATCCCCTGCT; ACTCCACTGACCTGGAAGAGCTGGGTACCAGGCCACCCACTGTGGGGCAAGCCTGAGTGG; TGAGGGGCCACTGGGCCCCATTCTCCCTCCATGGCAGGAAGGCGGGGGATTTCAAGTTTA; GGGATTGGGTCGTGGTGGAGAATCTGAGGGCACTCTCTGCCAGCTCCACAGGGTGGGATG; AGCCTCTCCTTGCCCCAGTCCTGGTTCAGTGGGAATGCAGTGGGTGGGGCTGTACACACC; CTCCAGCACAGACTGTTCCCTCCAAGGTCCTCTTAGGTCCCGGGAGGAACGTGGTTCAGA; GACTGGCAGCCAGGGAGCCCGGGGCAGAGCTCAGAGGAGTCTGGGAAGGGGCGTGTCCCT; CCTCTTCCTGTAGTGCCCCTCCCATGGCCCAGCAGCTTGGCTGAGCCCCCTCTCCTGAAG; CAGTGTCGCCGTCCCTCTGCCTTGCACAAAAAGCACAAGCATTCCTTAGCAGCTCAGGCG; CAGCCCTAGTGGGAGCCCAGCACACTGCTTCTCGGAGGCCAGGCCCTCCTGCTGGCTGAG; GCTTGGGCCCAGTAGCCCCAATATGGTGGCCCTGGGGAAGAGGCCTTGGGGGTCTGCTCT; GTGCCTGGGATCAGTGGGGCCCCAAAGCCCAGCCCGGCTGACCAACATTCAAAAGCACAA; ACCCTGGGGACTCTGCTTGGCTGTCCCCTCCATCTGGGGATGGAGAATGCCAGCCCAAAG; CTGGAGCCAATGGTGAGGGCTGAGAGGGCTGTGGCTGGGTGGTCAGCAGAAACCCCCAGG; AGGAGAGAGATGCTGCTCCCGCCTGATTGGGGCCTCACCCAGAAGGAACCCGGTCCCAGG; CCGCATGGCCCCTCCAGGAACATTCCCACATAATACATTCCATCACAGCCAGCCCAGCTC; CACTCAGGGCTGGCCCGGGGAGTCCCCGTGTGCCCCAAGAGGCTAGCCCCAGGGTGAGCA; GGGCCCTCAGAGGAAAGGCAGTATGGCGGAGGCCATGGGGGCCCCTCGGCATTCACACAC; AGCCTGGCCTCCCCTGCGGAGCTGCATGGACGCCTGGCTCCAGGCTCCAGGCTGACTGGG; GGCCTCTGCCTCCAGGAGGGCATCAGCTTTCCCTGGCTCAGGGATCTTCTCCCTCCCCTC; ACCCGCTGCCCAGCCCTCCCAGCTGGTGTCACTCTGCCTCTAAGGCCAAGGCCTCAGGAG; AGCATCACCACCACACCCCTGCCGGCCTTGGCCTTGGGGCCAGACTGGCTGCACAGCCCA; ACCAGGAGGGGTCTGCCTCCCACGCTGGGACACAGACCGGCCGCATGTCTGCATGGCAGA; AGCGTCTCCCTTGGCCACGGCCTGGGAGGGTGGTTCCTGTTCTCAGCATCCACTAATATT; CAGTCCTGTATATTTTAATAAAATAAACTTGACAAAGGAAAAAAAAAAAAAAA;
• Restriction Sites: Please inquire
• ACCN: NM_001034914
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• OTI Annotation: The ORF of this clone has been fully sequenced and found to be a perfect match to NM_001034914.1.
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001034914.1, NP_001030086.1
• RefSeq Size: 2735 bp
• RefSeq ORF: 693 bp
• Locus ID: 30818
• UniProt ID: Q9Y2W7
• Cytogenetics: 2q11.1
• Protein Families: Druggable Genome, Transcription Factors, Transmembrane
• Summary: This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]; Transcript Variant: This variant (2) includes an alternate in-frame segment in the 5' coding region and uses an alternate start codon, compared to variant 1. The resulting protein (isoform 2) is shorter and has a unique N-terminus, compared to isoform 1.