IL2 (NM_000586) Human Untagged Clone
IL2 (untagged)-Human interleukin 2 (IL2)
|Type||Human Untagged Clone|
|Synonyms||IL-2; lymphokine; TCGF|
|E. coli Selection||Ampicillin (100 ug/mL)|
>OriGene ORF within SC125234 sequence for NM_000586 edited (data generated by NextGen Sequencing)
Clone variation with respect to NM_000586.3
>OriGene 5' read for NM_000586 unedited
>OriGene 3' read for NM_000586 unedited
|Restriction Sites||Please inquire|
|OTI Disclaimer||Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).|
|Product Components||The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.|
|Reconstitution||1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
|RefSeq Size||1047 bp|
|RefSeq ORF||462 bp|
|Protein Families||Druggable Genome, Secreted Protein|
|Protein Pathways||Allograft rejection, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Graft-versus-host disease, Jak-STAT signaling pathway, T cell receptor signaling pathway, Type I diabetes mellitus|
|Gene Summary||This gene is a member of the interleukin 2 (IL2) cytokine subfamily which includes IL4, IL7, IL9, IL15, IL21, erythropoietin, and thrombopoietin. The protein encoded by this gene is a secreted cytokine produced by activated CD4+ and CD8+ T lymphocytes, that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2R) is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7. The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Sep 2020]|
|cDNA Clone Resources|
|RC210013||IL2 (Myc-DDK-tagged)-Human interleukin 2 (IL2)||
|RC210013L1||Lenti ORF clone of Human interleukin 2 (IL2), Myc-DDK-tagged||
|RC210013L2||Lenti ORF clone of Human interleukin 2 (IL2), mGFP tagged||
|RC210013L3||Lenti ORF clone of Human interleukin 2 (IL2), Myc-DDK-tagged||
|RC210013L4||Lenti ORF clone of Human interleukin 2 (IL2), mGFP tagged||
|RG210013||IL2 (GFP-tagged) - Human interleukin 2 (IL2)||