IL2 (NM_000586) Human Untagged Clone

CAT#: SC125234

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IL2 (untagged)-Human interleukin 2 (IL2)



  "NM_000586" in other vectors (6)

USD 462.00


Availability*
In Stock

Size
    • 10 ug


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Specifications

Product Data
Type Human Untagged Clone
Tag Tag Free
Symbol IL2
Synonyms IL-2; lymphokine; TCGF
Vector pCMV6-XL4
E. coli Selection Ampicillin (100 ug/mL)
Cell Selection None
Sequence Data
>OriGene ORF within SC125234 sequence for NM_000586 edited (data generated by NextGen Sequencing)
ATGTACAGGATGCAACTCCTGTCTTGCATTGCACTAAGTCTTGCACTTGTCACAAACAGT
GCACCTACTTCAAGTTCTACAAAGAAAACACAGCTACAACTGGAGCATTTACTTCTGGAT
TTACAGATGATTTTGAATGGAATTAATAATTACAAGAATCCCAAACTCACCAGGATGCTC
ACATTTAAGTTTTACATGCCCAAGAAGGCCACAGAACTGAAACATCTTCAGTGTCTAGAA
GAAGAACTCAAACCTCTGGAGGAAGTGCTAAATTTAGCTCAAAGCAAAAACTTTCACTTA
AGACCCAGGGACTTAATCAGCAATATCAACGTAATAGTTCTGGAACTAAAGGGATCTGAA
ACAACATTCATGTGTGAATATGCTGATGAGACAGCAACCATTGTAGAATTTCTGAACAGA
TGGATTACCTTTTGTCAAAGCATCATCTCAACACTGACTTGA

Clone variation with respect to NM_000586.3
114 g=>t
>OriGene 5' read for NM_000586 unedited
GACTCACTATAGGGCGGCCGCGAATTCCCTGCCACAATGTACAGGATGCAACTCCTGTCT
TGCATTGCACTAAGTCTTGCACTTGTCACAAACAGTGCACCTACTTCAAGTTCTACAAAG
AAAACACAGCTACAACTGGAGCATTTACTTCTGGATTTACAGATGATTTTGAATGGAATT
AATAATTACAAGAATCCCAAACTCACCAGGATGCTCACATTTAAGTTTTACATGCCCAAG
AAGGCCACAGAACTGAAACATCTTCAGTGTCTAGAAGAAGAACTCAAACCTCTGGAGGAA
GTGCTAAATTTAGCTCAAAGCAAAAACTTTCACTTAAGACCCAGGGACTTAATCAGCAAT
ATCAACGTAATAGTTCTGGAACTAAAGGGATCTGAAACAACATTCATGTGTGAATATGCT
GATGAGACAGCAACCATTGTAGAATTTCTGAACAGATGGATTACCTTTTGTCAAAGCATC
ATCTCAACACTGACTTGATAATTAAGTGCTTCCCACTTAAAACATATCAGGCCTCGACTC
TAGATTGCGGCCGCGGTCATANGCTGTTCCTGAACAGATTCCGGGTGGGATCCTTGTGAC
CCTTCCCATGGCGCTTTCGGGCCCGGAGTAGTCCTACTCAGGGCACACAACTTGGCCATA
AAAATAAATGGCACAATTTGTCCGCGAGAGGGGCCTCTAAAATATAGGGGGGGGGGGGGG
GGGGGGGGGGGCGCTTGGAAACACCGGTGGGCCG
>OriGene 3' read for NM_000586 unedited
ACCCATGGATCCTGGGCTGATGGCACTTNCCAGGNCCAGNAAAGCACTGGGGNAGGGTCA
CAGGGCATGCCACCCGGGTTCTGTTCAGGAAACAGCTATGACCGCGGCCGCAATCTAGAG
TCGAGGCCTGATATGTTTTAAGTGGGAAGCACTTAATTATCAAGTCAGTGTTGAGATGAT
GCTTTGACAAAAGGTAATCCATCTGTTCAGAAATTCTACAATGGTTGCTGTCTCATCAGC
ATATTCACACATGAATGTTGTTTCAGATCCCTTTAGTTCCAGAACTATTACGTTGATATT
GCTGATTAAGTCCCTGGGTCTTAAGTGAAAGTTTTTGCTTTGAGCTAAATTTAGCACTTC
CTCCAGAGGTTTGAGTTCTTCTTCTAGACACTGAAGATGTTTCAGTTCTGTGGCCTTCTT
GGGCATGTAAAACTTAAATGTGAGCATCCTGGTGAGTTTGGGATTCTTGTAATTATTAAT
TCCATTCAAAATCATCTGTAAATCCAGAAGTAAATGCTCCAGTTGTAGCTGTGTTTTCTT
TGTAGAACTTGAAGTAGGTGCACTGTTTGTGACAAGTGCAAGACTTAGTGCAATGCAAGA
CAGGAGTTGCATCCTGTACATTGTGGCAGGGAATTCGCGGCCGCCCTATAGTGAGTCGTA
TTACANAATTCTGACGGTTCACTAAACGAGCTCTGCTTATATAGACCTCCCACCGTACAC
GCCTACCGCCCATTTGCGTCAACGGNGCGGGGTTATTACGACATTTTGGAAAGTCCNGTT
GATTTTGGGTGCAAAACANACTCCCATTGACGTCAATGGGGTGGAGACTTGGAAATCCCC
GTGAGTCAAACCGCTATCCACGCCCATTGGTGTACTGGGCAAACCGCATCACCATGGTAA
TAGCGATGACTATACGTAGATTACTGGCAT
Restriction Sites Please inquire     
ACCN NM_000586
OTI Disclaimer Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
Product Components The cDNA clone is shipped in a 2-D bar-coded Matrix tube as dried plasmid DNA. The package also includes 100 pmols of both the corresponding 5' and 3' vector primers in separate vials. Every lot of primer is tested to provide clean sequencing of OriGene TrueClones.
Reconstitution 1. Centrifuge at 5,000xg for 5min.
2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
3. Close the tube and incubate for 10 minutes at room temperature.
4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
Reference Data
RefSeq NM_000586.2, NP_000577.2
RefSeq Size 1047 bp
RefSeq ORF 462 bp
Locus ID 3558
UniProt ID P60568
Cytogenetics 4q27
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Allograft rejection, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Graft-versus-host disease, Jak-STAT signaling pathway, T cell receptor signaling pathway, Type I diabetes mellitus
Gene Summary This gene is a member of the interleukin 2 (IL2) cytokine subfamily which includes IL4, IL7, IL9, IL15, IL21, erythropoietin, and thrombopoietin. The protein encoded by this gene is a secreted cytokine produced by activated CD4+ and CD8+ T lymphocytes, that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine (IL2R) is a heterotrimeric protein complex whose gamma chain is also shared by IL4 and IL7. The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Sep 2020]

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