FLCN (NM_144606) Human Untagged Clone

SKU SC123173

FLCN (untagged)-Human folliculin (FLCN), transcript variant 2

Product Data

• Type: Human Untagged Clone
• Target Symbol: FLCN
• Synonyms: BHD; DENND8B; FLCL
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_144606 edited; GGTCGCTCCTGGTTCTGCCAGCTCCCCTGAGAGCCTGAACCCGGGCTTGAGAGCCTCGCC; ACCCCGGGTGACATCCCTGCCGTGGGCTTGGGGGCTCTGGGTGTGATTCCGCCGGTCCGG; GTCCCGCAGCGACCACCTACCCAGCGCAGTCAGGGGTGGGGCTGGGACCCAGAGCGGGAC; CCCGGCTGCCGAGTCCAGGTGTCCCGCGGGCCTCGATTTGGGGAGCAGAAAACGCCAGGT; CTTCAAGGGTGTCTGCCACCACCATGCCTGACCCATTTGGCAGCAGCCTCGTGTGTGGTG; GTCTGGTGTGGACGGTGGAAGCGTGATTCTGCTGAGTGTCAGTGTGACCACTCGTGCTCA; GCCGTATCTCAGCAGGAGGACAGGTGCCGGAGCAGCTCGTGCAGCTAAGCAGCCAACTGC; AGAAACGTCAGGCCTGTTGCAGTCTCCAAGGCACCATGAATGCCATCGTGGCTCTCTGCC; ACTTCTGCGAGCTCCACGGCCCCCGCACTCTCTTCTGCACGGAGGTGCTGCACGCCCCAC; TTCCTCAAGGGGATGGGAATGAGGACAGTCCTGGCCAGGGTGAGCAGGCGGAAGAAGAGG; AAGGTGGCATTCAGATGAACAGTCGGATGCGTGCGCACAGCCCCGCAGAGGGGGCCAGCG; TCGAGTCCAGCAGCCCGGGGCCCAAAAAGTCGGACATGTGCGAGGGCTGCCGGTCACTTG; CTGCAGGGCACCCGGGATATATCAGCCATGATAAAGAGACCTCCATTAAATACGTCAGCC; ACCAGCACCCCAGCCACCCCCAGCTCTTCAGCATTGTCCGCCAGGCCTGTGTCCGGAGCC; TGAGCTGTGAGGTCTGCCCTGGCCGTGAAGGCCCCATCTTCTTCGGAGATGAGCAGCACG; GCTTTGTGTTCAGCCACACCTTCTTCATCAAGGACAGCCTGGCCAGGGGCTTCCAGCGCT; GGTACAGCATCATCACCATCATGATGGACCGGATCTACCTCATCAACTCCTGGCCCTTCC; TGCTGGGGAAGGTCCGGGGAATCATCGATGAGCTCCAGGGCAAGGCGCTCAAGGTGTTTG; AGGCAGAGCAGTTTGGATGCCCACAGCGTGCTCAGAGGATGAACACAGCCTTCACGCCAT; TCCTACACCAGAGGAACGGCAACGCCGCCCGCTCGCTGACATCGCTGACAAGTGATGACA; ACCTGTGGGCGTGCCTGCACACCTCCTTTGCCTGGCTCCTGAAGGCGTGTGGCAGCCGGC; TGACCGAGAAGCTCCTGGAAGGTGCTCCGACCGAGGATACCTTGGTCCAGATGGAGAAGC; TCGCTGGTGAGGCAGGGGTGCTGTTGCCGGGGCCTTGGCCCGGATGGCCGTGGGGCGGTA; CCAGCTGTCTGCTCTCCTGGCAGGAATCGCTGAGGGAGGGAAACGCGGCTCTGAATCAGC; CCAGAACGAGCCTTCGGGAAGCTCACCCTCCGATCTCGGTGTGATTGTTGTGATTGTTGT; GATTTCCTGTCTCGTTTGCCTTGACCGCCATGTGAAAGAATCTGTTCCCCAGCTAGGTGG; GGAAAATTCACAGGTGGGCTGTCTGTAGAGAGAACTGGCTGATTAAAGGCTTCTCGTCCC; GATTTTGTGATAGCCAAGTGCTTGGCCTGGTCGACGGTCTTTGCTCCTTTACAAATAAAG; TGTTCTGTTTCAAAAAAAAAAAAAAAAAAAA;
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_144606 unedited; NGCCTTCGCATTTGTATACGACTTATATAGGCGGCCCGATTCGCACGAGGGTCGCTCCTG; GTTCTGCCAGCTCCCCTGANAGCCTGAACCCGGGCTTGAGAGCCTCGCCACCCCGGGTGA; CATCCCTGCCGTGGGCTTGGGGGCTCTGGGTGTGATTCCGCCGGTCCGGGTCCCGCAGCG; ACCACCTACCCAGCGCAGTCAGGGGTGGGGCTGGGACCCAGAGCGGGACCCCGGCTGCCG; AGTCCAGGTGTCCCGCGGGCCTCGATTTGGGGAGCAGAAAACGCCAGGTCTTCAAGGGTG; TCTGCCACCACCATGCCTGACCCATTTGGCAGCAGCCTCGTGTGTGGTGGTCTGGTGTGG; ACGGTGGAAGCGTGATTCTGCTGAGTGTCAGTGTGACCACTCGTGCTCAGCCGTATCTCA; GCAGGAGGACAGGTGCCGGAGCAGCTCGTGCAGCTAAGCAGCCAACTGCAGAAACGTCAG; GCCTGTTGCAGTCTCCAAGGCACCATGAATGCCATCGTGGCTCTCTGCCACTTCTGCGAG; CTCCACGGCCCCCGCACTCTCTTCTGCACGGAGGTGCTGCACGCCCCACTTCCTCAAGGG; GATGGGAATGAGGACAGTCCTGGCCAGGGTGAGCAGGCGGAAGAAGAGGAAGGTGGCATT; CAGATGAACAGTCGGATGCGTGCGCACAGCCCCGCAGAGGGGGCCAGCGTCGAGTCCAGC; AGCCCGGGGCCCATAAGTCNGACATGTGCGATGGCTGCCGGTCACTTGCTGCAGGGCACC; CGGGATATATCAGCCATGATAAAGAGACCTCCATTAAATACGTCAGCCACCAGCACCCCA; GCCACCCCCAGCTCTTCAGCATTGTCCGCCAGGCCTGTGTCCAGAGCCTGG;
• Restriction Sites: Please inquire
• ACCN: NM_144606
• Insert Size: 1720 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_144606.4, NP_653207.1
• RefSeq Size: 1754 bp
• RefSeq ORF: 1029 bp
• Locus ID: 201163
• UniProt ID: Q8NFG4
• Cytogenetics: 17p11.2
• Protein Families: Druggable Genome
• Protein Pathways: Renal cell carcinoma
• Summary: This gene is located within the Smith-Magenis syndrome region on chromosome 17. Mutations in this gene are associated with Birt-Hogg-Dube syndrome, which is characterized by fibrofolliculomas, renal tumors, lung cysts, and pneumothorax. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]; Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, as compared to variant 1. Isoform 2 has a shorter and distinct C-terminus, as compared to isoform 1.