Retinoic Acid Receptor beta (RARB) (NM_000965) Human Untagged Clone

SKU SC119567

RARB (untagged)-Human retinoic acid receptor, beta (RARB), transcript variant 1

Product Data

• Type: Human Untagged Clone
• Target Symbol: Retinoic Acid Receptor beta
• Synonyms: HAP; MCOPS12; NR1B2; RARbeta1; RRB2
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC119567 sequence for NM_000965 edited (data generated by NextGen Sequencing); ATGTTTGACTGTATGGATGTTCTGTCAGTGAGTCCTGGGCAAATCCTGGATTTCTACACT; GCGAGTCCGTCTTCCTGCATGCTCCAGGAGAAAGCTCTCAAAGCATGCTTCAGTGGATTG; ACCCAAACCGAATGGCAGCATCGGCACACTGCTCAATCAATTGAAACACAGAGCACCAGC; TCTGAGGAACTCGTCCCAAGCCCCCCATCTCCACTTCCTCCCCCTCGAGTGTACAAACCC; TGCTTCGTCTGCCAGGACAAATCATCAGGGTACCACTATGGGGTCAGCGCCTGTGAGGGA; TGTAAGGGCTTTTTCCGCAGAAGTATTCAGAAGAATATGATTTACACTTGTCACCGAGAT; AAGAACTGTGTTATTAATAAAGTCACCAGGAATCGATGCCAATACTGTCGACTCCAGAAG; TGCTTTGAAGTGGGAATGTCCAAAGAATCTGTCAGGAATGACAGGAACAAGAAAAAGAAG; GAGACTTCGAAGCAAGAATGCACAGAGAGCTATGAAATGACAGCTGAGTTGGACGATCTC; ACAGAGAAGATCCGAAAAGCTCACCAGGAAACTTTCCCTTCACTCTGCCAGCTGGGTAAA; TACACCACGAATTCCAGTGCTGACCATCGAGTCCGACTGGACCTGGGCCTCTGGGACAAA; TTCAGTGAACTGGCCACCAAGTGCATTATTAAGATCGTGGAGTTTGCTAAACGTCTGCCT; GGTTTCACTGGCTTGACCATCGCAGACCAAATTACCCTGCTGAAGGCCGCCTGCCTGGAC; ATCCTGATTCTTAGAATTTGCACCAGGTATACCCCAGAACAAGACACCATGACTTTCTCA; GACGGCCTTACCCTAAATCGAACTCAGATGCACAATGCTGGATTTGGTCCTCTGACTGAC; CTTGTGTTCACCTTTGCCAACCAGCTCCTGCCTTTGGAAATGGATGACACAGAAACAGGC; CTTCTCAGTGCCATCTGCTTAATCTGTGGAGACCGCCAGGACCTTGAGGAACCGACAAAA; GTAGATAAGCTACAAGAACCATTGCTGGAAGCACTAAAAATTTATATCAGAAAAAGACGA; CCCAGCAAGCCTCACATGTTTCCAAAGATCTTAATGAAAATCACAGATCTCCGTAGCATC; AGTGCTAAAGGTGCAGAGCGTGTAATTACCTTGAAAATGGAAATTCCTGGATCAATGCCA; CCTCTCATTCAAGAAATGCTGGAGAATTCTGAAGGACATGAACCCTTGACCCCAAGTTCA; AGTGGGAACACAGCAGAGCACAGTCCTAGCATCTCACCCAGCTCAGTGGAAAACAGTGGG; GTCAGTCAGTCACCACTCGTGCAATAA; ; Clone variation with respect to NM_000965.3;
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_000965 unedited; GCATTTTGTATACGACTCACTATAGGGCGGCCGCGCAATTCGCACGAGGGTCTGTCATAA; TTCATGGATTCGGGNNGCTGGGAAAAAGACCAACAGCCTACGTGCCAAAAAAGGGCAGAG; TTTGATGGAGTTGGGTGGACTTTTCTATGCCATTTGCCTCCACACCTAGAGGATAAGCAC; TTTTGCAGACATTCAGTGCAAGGGAGATCATGTTTGACTGTATGGATGTTCTGTCAGTGA; GTCCTGGGCAAATCCTGGATTTCTACACTGCGAGTCCGTCTTCCTGCATGCTCCAGGAGA; AAGCTCTCAAAGCATGCTTCAGTGGATTGACCCAAACCGAATGGCAGCATCGGCACACTG; CTCAATCAATTGAAACACAGAGCACCAGCTCTGAGGAACTCGTCCCAAGCCCCCCATCTC; CACTTCCTCCCCCTCGAGTGTACAAACCCTGCTTCGTCTGCCAGGACAAATCATCAGGGT; ACCACTATGGGGTCAGCGCCTGTGAGGGATGTAAGGGCTTTTTCCGCAGAAGTATTCAGA; AGAATATGATTTACACTTGTCACCGAGATAAGAACTGTGTTATTAATAAAGTCACCAGGA; ATCGATGCCAATACTGTCGACTCCAGAAGTGCTTTGAAGTGGGAATGTCCAAAGAATCTG; TCAGGAATGACAGGGAACAGAAAAAGAAGGAGACTTCGAAGCAAGAATGCACAGAGAGCT; ATGAAATGACAGCTGAGTTGGACGATCTCACAGAGAAGATCCGAAAGCTCNACCAGAAAC; TTTCCCTCACTCTGCCAGCTGGGTAAATACACCACGAATTCCAGTGCTGACCATCGAGTT; CGACTGGACCTGGGCCTCTGGGACAAATTCATTGAACTGGCCACCAGTGCATTATTAAGA; TCGGGNAGATTGCTAAACGCTTGCCTGGTTCACTGGCTTGACATCGCAAACN;
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_000965 unedited; GGGGCTTTTGTGTGTTTTATGCTTTGCCGGNANACTCCTGGGAAAAGGTAAACAGTATAT; GAACATAGAAAGCATTGTTAAACAAACAATCTCAATGTACAAACAGAGCCAGTGAAAGTA; CATCACAGACTTGCTAATATATCAAAAAAAAAAAATTCCACTAGTGCTTAAATGAGAACT; AAGAAACTGACACTTGTATCTGTTAACCACTCTACCACAGCTTTCACTCTGCTTCATAGT; GATTGAACAAGGTCAAAGGAGGCAGATTCTATGCCTGTTTCTTTGGGAGTTGTTAATATT; AATTAGCCCCTTGGCATCAAGAAGGCTGGAAAAAAAAATCCCAATATCAGGCATGAATCA; GGAAGGACACTAGAGTTACATGGTCCAGGTGGTAGACCAGCCTGCTAATTATCCCATGAA; ATTTCCCTAATGGCTTGTGAACAAGTAAACAAAAACTTAACACTGAAAAGTGTTTCTGCC; TTGGAGGCTATCATTACTGTAAAAAAATTTTTTTTTAACTGTGTAGTTATGTCATTAAAC; AAGTAATAAACCACTTTTAATTTAAAGTGACATTAACAATTGAACAAATGACATTTGATT; AACTGAACTGGCAGTTACACTGATACAGAATTCTCTTCTGCTAGTGCAGGGAATTTGTAT; ACTTTTACTGGGCAACATGAAATAAAAGATGCAGTTTGAGAGCATTAGAAAGAGCAAAGA; CAAGCCTCCCTACTAACCAAAGTAGAATATCTCTAGCCTTATCTTGTCATACTGTACATA; ATTCCTGTCCATAGACCTGTTTCCCTACCTTGAGTCTTGACTATTCCCCGAAACCCACAC; AGTTATTTTCTTGAACCTAGGTAAACCTGACCAGCAACCTATTTCTTAACCCTCGCGGCC; TGGCTCATTTTGATTTTGCAAAAAAACAGGAAAC;
• Restriction Sites: NotI-NotI
• ACCN: NM_000965
• Insert Size: 2900 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_000965.2, NP_000956.2
• RefSeq Size: 3119 bp
• RefSeq ORF: 1347 bp
• Locus ID: 5915
• UniProt ID: P10826
• Cytogenetics: 3p24.2
• Domains: HOLI, zf-C4
• Protein Families: Druggable Genome, Nuclear Hormone Receptor, Transcription Factors
• Protein Pathways: Non-small cell lung cancer, Pathways in cancer, Small cell lung cancer
• Summary: This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014]; Transcript Variant: This variant (1, also known as beta-2) is a predominant transcript. This variant can initiate translation from an upstream AUG site and also from a downstream, in-frame AUG site (PMID: 12118004). The isoform (1) represented in this RefSeq is derived from the upstream AUG start codon. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.