ADCY8 (NM_001115) Human Untagged Clone

SKU SC119443

ADCY8 (untagged)-Human adenylate cyclase 8 (brain) (ADCY8)

Product Data

• Type: Human Untagged Clone
• Target Symbol: ADCY8
• Synonyms: AC8; ADCY3; HBAC1
• Vector: pCMV6-XL6
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC119443 sequence for NM_001115 edited (data generated by NextGen Sequencing); ATGGAGCTCTCCGATGTGCGCTGCCTTACAGGCAGCGAGGAACTCTACACCATCCACCCG; ACGCCCCCGGCCGGCGACGGCAGGAGCGCCTCCCGGCCGCAGCGGCTGCTGTGGCAGACG; GCGGTGCGACACATCACGGAGCAGCGCTTCATTCACGGGCACCGGGGAGGCAGCGGCAGC; GGGAGTGGAGGCTCGGGCAAAGCCTCGGACCCTGCGGGCGGCGGCCCCAACCACCACACG; CCGCAGCTGTCAGGCGACTCGGCGCTGCCCCTCTACTCGCTGGGCCCGGGAGAGCGAGCG; CACAGCACCTGCGGCACCAAAGTCTTCCCGGAACGCAGCGGGAGCGGCAGTGCCAGCGGC; AGCGGAGGCGGGGGCGACCTGGGCTTCCTGCACCTTGACTGTGCCCCTAGCAACTCGGAT; TTCTTTCTTAATGGGGGCTATAGCTACCGAGGGGTCATTTTCCCCACCCTGCGCAACTCC; TTCAAATCTCGGGATTTGGAACGCCTCTACCAGCGCTATTTCTTGGGCCAAAGGCGCAAA; TCGGAAGTGGTGATGAACGTGCTGGACGTGCTGACCAAACTCACTCTCTTGGTCCTACAC; TTGAGCCTGGCCTCGGCCCCCATGGACCCGCTCAAGGGCATCCTGCTGGGCTTCTTCACC; GGCATTGAGGTAGTGATCTGCGCCCTGGTGGTGGTCAGGAAGGACACCACCTCCCACACG; TACCTGCAGTACAGCGGCGTGGTCACCTGGGTGGCCATGACCACCCAGATCCTGGCAGCA; GGCCTCGGCTACGGGCTCCTGGGCGACGGCATAGGCTACGTGCTCTTCACGCTCTTCGCC; ACCTACAGTATGCTGCCGCTGCCGCTCACCTGGGCCATCCTGGCCGGCCTGGGCACCTCG; CTGCTGCAGGTCATCCTCCAAGTGGTCATACCCCGGCTGGCGGTCATTTCCATCAACCAG; GTTGTGGCCCAGGCAGTGCTATTCATGTGTATGAACACAGCTGGAATCTTCATCAGTTAC; CTGTCAGACCGTGCCCAGCGCCAAGCTTTCCTGGAGACTCGGAGGTGTGTGGAGGCCAGG; CTGCGCCTGGAGACAGAGAACCAAAGACAGGAGCGGCTCGTGCTTTCTGTGCTCCCCCGG; TTTGTTGTCCTGGAAATGATCAACGACATGACCAATGTGGAAGATGAGCACCTGCAGCAC; CAGTTCCATCGGATCTACATCCATCGCTATGAGAACGTCAGTATTCTTTTTGCAGATGTT; AAAGGATTTACCAACCTCTCCACGACCTTGTCTGCTCAGGAGCTGGTCAGGATGCTCAAC; GAGCTCTTTGCCAGATTTGATCGACTGGCCCATGAGCATCACTGCCTTCGTATTAAAATC; CTGGGGGACTGCTACTACTGCGTGTCTGGACTTCCTGAGCCCCGCCAGGACCATGCCCAC; TGCTGTGTTGAAATGGGTCTCAGCATGATCAAAACCATCAGGTATGTGCGGTCAAGGACA; AAACACGATGTTGACATGAGGATTGGAATCCACTCCGGCTCGGTGCTGTGCGGTGTTTTG; GGACTAAGGAAGTGGCAGTTTGATGTCTGGTCTTGGGATGTGGATATTGCAAACAAACTC; GAATCTGGAGGAATCCCTGGGAGGATTCACATTTCCAAAGCCACGCTGGACTGTCTCAAC; GGTGACTATAACGTGGAAGAGGGCCATGGTAAAGAGAGGAATGAATTCCTGAGGAAGCAT; AATATCGAAACTTACTTAATTAAGCAGCCTGAGGACAGTCTGCTGTCCTTGCCTGAAGAT; ATCGTCAAGGAGTCAGTGAGCTCCTCAGACCGGAGAAACAGTGGGGCCACATTCACTGAA; GGATCCTGGAGCCCTGAACTGCCCTTTGATAATATCGTGGGGAAACAGAATACTCTGGCT; GCCCTAACAAGAAATTCAATAAATCTGCTTCCAAACCATCTTGCACAAGCTTTGCATGTC; CAGTCTGGGCCTGAGGAAATTAACAAGAGAATAGAACATACCATCGACTTGCGGAGTGGC; GATAAATTGAGAAGAGAGCATATCAAGCCATTCTCACTGATGTTTAAAGACTCCAGCCTG; GAGCACAAGTATTCTCAAATGAGGGATGAAGTGTTCAAGTCAAACTTGGTCTGTGCATTT; ATCGTTCTTCTATTTATCACGGCAATACAAAGTTTGCTTCCTTCTTCAAGAGTGATGCCA; ATGACCATCCAGTTCTCCATTCTGATTATGCTGCACTCGGCTCTGGTCCTCATCACCACA; GCAGAGGATTATAAATGTTTGCCCCTCATCCTCCGGAAAACTTGCTGTTGGATTAATGAG; ACCTATTTGGCCCGGAACGTCATCATCTTTGCATCCATTTTGATTAATTTCCTGGGTGCC; ATCTTAAATATCCTGTGGTGTGATTTTGACAAGTCGATACCCTTGAAGAACCTGACTTTC; AATTCCTCAGCTGTGTTTACAGATATCTGCTCCTACCCAGAGTACTTTGTCTTCACGGGG; GTGTTGGCCATGGTGACCTGTGCAGTTTTCCTCCGGCTGAACTCCGTCCTGAAGCTGGCA; GTGCTGCTGATCATGATTGCCATCTATGCCCTGCTCACTGAGACCGTCTACGTAGGCCTC; TTTCTGCGTTATGACAACCTCAACCACAGTGGAGAAGATTTCCTGGGGACCAAGGAGGTA; TCACTGCTACTGATGGCCATGTTCCTCCTGGCTGTGTTCTACCATGGACAGCAGCTGGAG; TACACAGCCCGCCTGGACTTCCTTTGGCGAGTACAGGCCAAAGAGGAGATCAATGAGATG; AAGGAGCTGAGGGAACACAATGAGAACATGCTCCGGAATATCTTACCCAGCCATGTGGCC; CGCCATTTCCTAGAGAAGGACCGAGACAATGAGGAGCTGTATTCTCAATCCTATGATGCT; GTTGGGGTGATGTTTGCCTCCATCCCAGGATTTGCGGACTTTTACTCTCAGACTGAAATG; AATAACCAGGGAGTGGAATGCCTGCGCTTGCTCAATGAGATCATTGCTGACTTCGATGAG; TTGCTTGGTGAAGACCGATTTCAAGACATTGAAAAGATTAAGACCATTGGCAGCACCTAC; ATGGCCGTGTCAGGCCTGTCACCTGAAAAACAGCAATGTGAAGACAAGTGGGGACATTTG; TGTGCTCTGGCTGACTTCTCACTCGCCCTGACAGAAAGCATACAGGAGATCAACAAGCAT; TCATTCAACAATTTTGAACTCCGGATTGGCATCAGCCACGGCTCAGTGGTAGCTGGCGTT; ATCGGCGCTAAGAAACCACAGTATGACATTTGGGGCAAAACTGTGAACCTGGCAAGCCGA; ATGGACAGCACGGGGGTTAGTGGCCGGATCCAAGTCCCAGAGGAGACCTATCTCATCCTG; AAGGACCAGGGCTTTGCCTTTGATTACCGAGGGGAGATCTATGTGAAGGGTATCAGTGAA; CAGGAAGGAAAAATCAAAACGTACTTTCTTCTGGGAAGAGTCCAACCCAACCCATTCATC; TTGCCCCCAAGAAGACTGCCTGGGCAGTACTCCCTGGCCGCGGTTGTCCTGGGACTTGTC; CAGTCCCTCAATAGGCAAAGGCAGAAGCAGCTACTCAATGAGAACAACAACACAGGAATC; ATCAAGGGTCATTACAACCGGCGGACTTTGTTGTCACCCAGCGGCACAGAGCCTGGAGCC; CAGGCTGAAGGCACCGACAAATCTGATTTGCCATAA; ; Clone variation with respect to NM_001115.2; 238 g=>a;1032 g=>t;2633 c=>t
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_001115 unedited; AACGTCAGCCGCCCGTTCNCGCTAATGGGCGTAGGCGTGTACGGTGGGAGGTCTATATAA; GCAGAGCTCATTTAGGTGACACTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCG; CGAATTCGGCACGAGGCCCAAGCTGCGCCGGCTGGCGGGAGAGCAGCACGCAAGGACGCC; GAGGTCCGCCGCGATCTTCCAGGTGCCCTTTGCCCCTGGGCACAGTATGACCCGACCTAC; AGGGAGCCCTAGCGCAGGGCTCCTGCAACGGGGCAGCCTAGGATAAAAAGGATCCTTGCC; AAGCTCCTACCAGGCCGCCTTTGAGTCTTTAGGAACCCCTCCTCCGGCTGCCTCCCCAAG; GTTCTGGGCCTCCTTCCCTGCGGCCCAGAGCCATGGAGCTCTCCGATGTGCGCTGCCTTA; CAGGCAGCGAGGAACTCTACACCATCCACCCGACGCCCCCGGCCGGCGACGGCAGGAGCG; CCTCCCGGCCGCAGCGGCTGCTGTGGCAGACGGCGGTGCGACACATCACGGAGCAGCGCT; TCATTCACGGGCACCGGGGAGGCAGCGGCAGCGGGAGTGGAGGCTCGGGCAAAGCCTCGG; ACCCTGCGGGCGGCGGCCCCAACCACCACACGCCGCAGCTGTCAGGCGACTCGGCGCTGC; CCCTCTACTCGCTGGGCCCGGGAGAGCGAGCGCACAGCACCTGCGGCACCAAAGTCTTCC; CGGAACGCAGCGGGAGCGGCAGTGCCAGCGGCAGCGGAAGCGGGGGCGACCTGNGCTTCC; TGCACCTTGACTGTGCCCCTAGCAACTCGGATTTCTTTCTTAATGGGGGCTATAGCTACC; CGAGGGTCATTTTCCCCCCCTGCGCACTCCTTCAATCTCGGGATTGGAACGCCTCTACCA; GCGCTATT;
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_001115 unedited; AGNGTGGCACTGGGGNGGGGTCACAGGGCTGCCACCCGGGCTCTGTTCAGGAAACAGCTA; TGACCGCGGCCGCAATCTATAGTCGAGTTTTTTTTTTTTTTTTTTCTAAAAAAAATTAAA; CCTTTTTATTAGTATATTTATTTTATATATAAAAGAAATACAAAAAAAAAAAAAACAGAA; AGAAAATGCTTTTATGGCAAATCAGATTTGTCGGTGCCTTCAGCCTGGGCTCCAGGCTCT; GTGCCGCTGGGTGACAACAAAGTCCGCCGGTTGTAATGACCCTTGATGATTCCTGTGTTG; TTGTTCTCATTGAGTAGCTGCTTCTGCCTTTGCCTATTGAGGGACTGGACAAGTCCCAGG; ACAACCGCGGCCAGGGAGTACTGCCCAGGCAGTCTTCTTGGGGGCAAGATGAATGGGTTG; GGTTGGACTCTTCCCAGAAGAAAGTACGTTTTGATTTTTCCTTCCTGTTCACTGATACCC; TTCACATAGATCTCCCCTCGGTAATCAAAGGCAAAGCCCTGGTCCTTCAGGATGAGATAG; GTCTCCTCTGGGACTTGGATCCGGCCACTAACCCCCGTGCTGTCCATTCGGCTTGCCAGG; TTCACAGTTTTGCCCCAAATGTCATACTGTGGTTTCTTAGCGCCGATAACGCCAGCTACC; ACTGAGCCGTGGCTGATGCCAATCCGGAGTTCAAAATTGTAGAATGAATGCTTGTTGATC; TCCTGTATGCTTTCTGTCAGGGCGAGTGAGAAGTCAGCCAGAGCACACAAATGTCCCCAC; TTGGTCTCACATTGCTGTTTTTTAAGTGACAGGCCTGACACGGCCATGTAGGTGCTGCAA; GGGTCTTATCCTTTCATGTCNTGAAATGGGTCTTAACCAGCACTCATCGAG;
• Restriction Sites: NotI-NotI
• ACCN: NM_001115
• Insert Size: 4700 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001115.1, NP_001106.1
• RefSeq Size: 6005 bp
• RefSeq ORF: 3756 bp
• Locus ID: 114
• UniProt ID: P40145
• Cytogenetics: 8q24.22
• Domains: CYCc
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Calcium signaling pathway, Chemokine signaling pathway, Dilated cardiomyopathy, Gap junction, GnRH signaling pathway, Long-term potentiation, Melanogenesis, Oocyte meiosis, Progesterone-mediated oocyte maturation, Purine metabolism, Taste transduction, Vascular smooth muscle contraction
• Summary: Adenylate cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008]