Caveolin 2 (CAV2) (NM_001233) Human Untagged Clone

SKU SC119366

CAV2 (untagged)-Human caveolin 2 (CAV2), transcript variant 1

Product Data

• Type: Human Untagged Clone
• Target Symbol: Caveolin 2
• Synonyms: CAV
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_001233, the custom clone sequence may differ by one or more nucleotides; ; ; ATGGGGCTGGAGACGGAGAAGGCGGACGTACAGCTCTTCATGGACGACGACTCCTACAGCCACCACAGCG; GCCTCGAGTACGCCGACCCCGAGAAGTTCGCGGACTCGGACCAGGACCGGGATCCCCACCGGCTCAACTC; GCATCTCAAGCTGGGCTTCGAGGATGTGATCGCAGAGCCGGTGACTACGCACTCCTTTGACAAAGTGTGG; ATCTGCAGCCATGCCCTCTTTGAAATCAGCAAATACGTAATGTACAAGTTCCTGACGGTGTTCCTGGCCA; TTCCCCTGGCCTTCATTGCGGGAATTCTCTTTGCCACCCTCAGCTGTCTGCACATCTGGATTTTAATGCC; TTTTGTAAAGACCTGCCTAATGGTTCTGCCTTCAGTGCAGACAATATGGAAGAGTGTGACAGATGTTATC; ATTGCTCCATTGTGTACGAGCGTAGGACGATGCTTCTCTTCTGTCAGCCTGCAACTGAGCCAGGATTGA; ;
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_001233 unedited; NCCCGTTCAAATATTTGTATACGACTCACTTNGGGCGGCCGCGNAATTCGCACGAGGGCG; AGGGGGGGCGGGGCCGGGCGCTACGGGAAGGGGAGGCCGCGCGGACCGGGAGCCGCACCG; CGCCAGCCGGGCTGCAGCGGCCGCGCACCAAGGCTGCGATGGGGCTGGAGACGGAGAAGG; CGGACGTACAGCTCTTCATGGACGACGACTCCTACAGCCACCACAGCGGCCTCGAGTACG; CCGACCCCGAGAAGTTCGCGGACTCGGACCAGGACCGGGATCCCCACCGGCTCAACTCGC; ATCTCAAGCTGGGCTTCGAGGATGTGATCGCAGAGCCGGTGACTACGCACTCCTTTGACA; AAGTGTGGATCTGCAGCCATGCCCTCTTTGAAATCAGCAAATACGTAATGTACAAGTTCC; TGACGGTGTTCCTGGCCATTCCCCTGGCCTTCATTGCGGGAATTCTCTTTGCCACCCTCA; GCTGTCTGCACATCTGGATTTTAATGCCTTTTGTAAAGACCTGCCTAATGGTTCTGCCTT; CAGTGCAGACATATTGGAAGAGTGTGACAGATGTTATCATTGCTCCATTGTGTACGAGCG; TAGGACGATGCTTCTCTTCTGTCAGCCTGCAACTGACCCAGGATTGAATACTTGGACCCC; ANGTCTGGGAGATTGGGATACTGTNAATACTTCTTTGTTATTATAACATAAAAGCACCAC; TGGTTCTGTTCATTTCCCTAGCTGTTCTAATTAAGAAACCTATTAAGATGAGCAACCACA; TTTAGGAATGGTTTATTGACCAGGTCTTTTCAAATAATGGCTTTTCTAATTAATAGCCCA; AAGATTTCATATCTTNACTTTGTTACCCGATTATCCCGNTAAGTTGACCCACTTAGATTT; AAGGCGGAACAGTTTTGCTTAGTACAATAGTATACT;
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_001233 unedited; ACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTCTTTTTTTTTTTGAGAC; AGACTCTTGCTCTGTTGCCAGGCGGGAGTGCAGTGGCATGATTTTGGCTCACTGCAACCT; CTGCCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAGGTAGCTGGGACTACAGG; TGCATGCCACCATGCCCAACTAATTTTTTTGTATTTTTAGTAGAGACGGGGTATCACCAT; GTTGGCCAGGATGGTCTTGATCTCCTGACCTCATGATCCACCCGCCTTGGCCTCCCAAAG; TGCTGGGATTACAGGGGTGAGCCACCATGCCCGGCCCAGAAATAATGAGATTTTTCAAAG; CAACAGTGATTCATCACACTGAAATAGGACTCTACAGTTCAAAATGACAAGAATAACTTT; ATCCTGTGTTACATACCAATATTAGAGAAATCTTAAAAGTTTGTAGCTGTTAGTTTTTAG; TTTATGCATGTAGTTCAGTAGCCCAAGTTGACAACTCCCCTGTCTCTCTACATGAATCAC; TGTAGTTGAAATTGTACTAAAGTATCAGAAGTAACATTTACTGTAAAATGTTAAATAGCA; CCAATATTACTTGAAAGTAAAGTGAGACATTAATAGGAATGCTGACACAGATTTAATTNC; TAACTACTAGAGAGAAAGCATCTCCTAGACAAAATACTATTTAGATATGAATTATTTCAG; GATCACAGCCAGAAAAAGTCATAAAACATTTTAGATTTTGCTTTGAAAAGTTAGAAAAAG; AAGCTTTGNGTATCGCTCTTTTATCCTTTATTTCCCAGNAAAATGTACAAATGCTTNACT; TATTCAGAACAGTGCAATCTTACCAATGAAATTTACCTTGGGGGGAGCCACATTTACTTA; TTCCATAAATAAGTTCACCC;
• Restriction Sites: NotI-NotI
• ACCN: NM_001233
• Insert Size: 2140 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_001233.3, NP_001224.1
• RefSeq Size: 3332 bp
• RefSeq ORF: 489 bp
• Locus ID: 858
• UniProt ID: P51636
• Cytogenetics: 7q31.2
• Domains: Caveolin
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Focal adhesion
• Summary: The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462). [provided by RefSeq, May 2011]; Transcript Variant: This variant (1) encodes two isoforms resulting from the use of alternate in-frame, translation initiation codons. This RefSeq represents the longer isoform (a, also known as alpha) derived from the use of the upstream AUG (at nt 182-184). Isoform alpha has been shown to localize mostly in the golgi (PMID:11238462).