CAMLG (NM_001745) Human Untagged Clone

CAT#: SC119078

CAMLG (untagged)-Human calcium modulating ligand (CAMLG)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: CAMLG
• Synonyms: CAML; GET2
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC119078 sequence for NM_001745 edited (data generated by NextGen Sequencing)
  ATGGAGTCGATGGCCGTCGCTACCGACGGCGGGGAGAGGCCGGGGGTCCCAGCGGGCTCA
  GGTCTGTCGGCTTCCCAGCGTCGGGCGGAGCTGCGTCGGAGAAAGCTGCTCATGAACTCG
  GAACAGCGCATCAACCGGATCATGGGCTTTCACAGGCCCGGGAGCGGCGCGGAAGAAGAA
  AGTCAAACAAAATCAAAGCAGCAGGACAGTGATAAACTGAACTCCCTCAGCGTTCCTTCC
  GTTTCAAAGCGAGTAGTGCTGGGTGATTCAGTCAGTACAGGAACAACTGACCAGCAGGGT
  GGTGTGGCCGAGGTAAAGGGGACCCAACTGGGAGACAAATTGGACTCGTTCATTAAACCA
  CCTGAGTGCAGTAGTGATGTCAACCTTGAGCTCCGGCAGCGGAACAGAGGGGACCTGACA
  GCGGACTCGGTCCAGAGGGGTTCCCGCCATGGCCTAGAGCAGTACCTTTCCAGATTCGAA
  GAAGCAATGAAGCTAAGGAAACAGCTGATTAGTGAAAAACCCAGTCAAGAGGATGGAAAT
  ACAACAGAAGAATTTGACTCTTTTCGAATATTTAGATTGGTGGGATGTGCTCTTCTTGCT
  CTTGGAGTCAGAGCTTTTGTTTGCAAATACTTGTCCATATTTGCTCCATTTCTTACTTTA
  CAACTTGCGTACATGGGATTATACAAATATTTTCCCAAGAGTGAAAAGAAGATAAAGACA
  ACAGTACTAACAGCTGCACTTCTATTGTCGGGAATTCCTGCCGAAGTGATAAATCGATCA
  ATGGATACCTATAGCAAAATGGGCGAAGTCTTCACAGATCTCTGTGTCTACTTTTTCACT
  TTTATCTTTTGTCATGAACTGCTTGATTATTGGGGCTCTGAAGTACCATGA
  
  Clone variation with respect to NM_001745.3
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_001745 unedited
  GGGTGGATTTGAAACCGACTTCCTATAGGGCGGCCGCGCATTCGGCACGAGGGCCACTGT
  TCTCCCCTCCCANACTGTGGACGGGAGGCTGGAGTCGATGGCCGTCGCTACCGACGGCGG
  GGAGAGGCCGGGGGTCCCAGCGGGCTCAGGTCTGTCGGCTTCCCAGCGTCGGGCGGAGCT
  GCGTCGGAGAAAGCTGCTCATGAACTCGTTTCTGTGTATCAACCGGATCATGGGCTTTCA
  CAGGCCCGGGAGCGGCGCGGAAGAAGAAAGTCAAACAAAATCAAAGCAGCAGGGACAGTG
  ATAAACTGAACTCCCTCAGCGTTCCTTCCGTTTCAAAGCGAGTAGTGCTGGGTGATTCAC
  TCAGTACAGGAACAACTGACCAGCAGGGTGGTGTGGCCGAGGTAAAGGGGACCCAACTGG
  GAGACAAATTGGACTCGTTCATTAAACCACCTGAGTGCAGTAGTGATGTCAACCTTGAGC
  TCCGGCAGCGGAACAGAGGGGACCTGACAGCGGACTCGGTCCAGAGGGGTTCCCGCCATG
  GCCTAGAGCAGTACCTTTCCAGATTCGAAGAAGCAATGAAGCTAAGGAAACAGCTGATTA
  GTGAAAAACCCCACTCAGAGGATGGAAATACAACAGAAGAATTTGACTCTTTTCGAATAT
  TTAGATTGGTGGGATGTGCCTCTNTTTGCTCTTGGAGTCAGAGCTTTTGTTTGCCAATAC
  CTGCCCATATTTGCTCCATTTCTTACTTTCCACTTGCGCACATGGGAATATACCAAAATT
  TTCCCCGGAGCCGAAAGGACATTAAGACCACCGTCCTAACCCCTGCCCTTCTATTGCCGG
  GAATCCCTGCCCCAATGATAAACCGCCCATGGATACCTATCGCAAAAGGGCGAAGCCTCC
  CAGACCTCTGGGTCTCCTTTTCCCTT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_001745 unedited
  TAAAATCCCCTCGTTTGACTTCATTTCTCAGGACAGAATGACACAAACACAAAAAGCATT
  TTCTAGGGCTGGCTGAGACCACATTTATCTGTTCTCCTAAAAGCACTAGCTCAGCTCCCA
  AAAGAAGAATTACAAATCTGAGAAGTTAGAGGAAAGGTACAGAATATGAATTCTGATTAA
  CAAGAAAAATCAATTAATGACATTGGTACTCTATTTTTCATATCAGTAATAATACAAACT
  CAGCCCTTTTAAATCAGAGAATCTGCCATTCTATATCTAATAAAGTAGCTTTACAACCCC
  TAAAGTAAAAGAATTACATGAAGGTGTAAACCAATTTGCATCCTTTAGAGACACTGCAAT
  ATATAAGAGGATTTTTTTTTTTTTGCAAGCTTCTCCTTCTCAGTTCTACAGGTTTTATGG
  TACTTCAGAGCCCCAATAATCAATCAGTTCATGACTAAAGATAAAAGTGAACAAGTCCAC
  ACAGAGATCTGTGAAGACATCCGCCATTTTGCTATAGGTATCCATTGATCGATTTATTAC
  TCCGGGGGGAATTCTTGTCTTTAGAAGGGACCCTTGCAATAACGGTGGCCACATACTTCT
  TTTATTTTTTGGAAAATTTTGTCTATCTCCAGGCCTCCCTTTCAAATGTATATATGGTCC
  ATTTGGCCCACTTTTTGATTACATAACCTTTGCTCCCACCCCAGACTATTTTTTCTTCAC
  TTTATTATCCACAAAGCAAAATTCTTTGTAAGATTTCAATCCTTCGGGCGGGTTTATAAC
  TTACAAGGGTTTCTCCTTTTCTTCGTCACTTTTATCCCGAGTGTTCTTCATTCGCTATAC
  GGGAACCCCTTGTGCCGTTTAATTTTATTGTCCACTTCTACCTTTTTGTGTTCTGGGTTC
  AACTCTCCGCAGTGGTACATTGATCGCACTTTCTTTTTTCACCGCCCTCCTATCTTTTTA
  TACTCCTCTCGTCAACTGTCCCCCGCCNAATCGTCACCATATCTCCTTCCCTCCCCTATT
  CACACGCTTCTCCATGTCACTATCTCTCCG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_001745
• Insert Size: 1440 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001745.2, NP_001736.1
• RefSeq Size: 2203 bp
• RefSeq ORF: 891 bp
• Locus ID: 819
• UniProt ID: P49069
• Cytogenetics: 5q31.1
• Protein Families: Druggable Genome
• Gene Summary: The immunosuppressant drug cyclosporin A blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. When bound to cyclophilin B, cyclosporin A binds and inactivates the key signaling intermediate calcineurin. The protein encoded by this gene functions similarly to cyclosporin A, binding to cyclophilin B and acting downstream of the TCR and upstream of calcineurin by causing an influx of calcium. This integral membrane protein appears to be a new participant in the calcium signal transduction pathway, implicating cyclophilin B in calcium signaling, even in the absence of cyclosporin. [provided by RefSeq, Jul 2008]