LOX 1 (OLR1) (NM_002543) Human Untagged Clone

SKU SC118589

OLR1 (untagged)-Human oxidized low density lipoprotein (lectin-like) receptor 1 (OLR1), transcript variant 1

Product Data

• Type: Human Untagged Clone
• Target Symbol: LOX 1
• Synonyms: CLEC8A; LOX1; LOXIN; SCARE1; SLOX1
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC118589 sequence for NM_002543 edited (data generated by NextGen Sequencing); ATGACTTTTGATGACCTAAAGATCCAGACTGTGAAGGACCAGCCTGATGAGAAGTCAAAT; GGAAAAAAAGCTAAAGGTCTTCAGTTTCTTTACTCTCCATGGTGGTGCCTGGCTGCTGCG; ACTCTAGGGGTCCTTTGCCTGGGATTAGTAGTGACCATTATGGTGCTGGGCATGCAATTA; TCCCAGGTGTCTGACCTCCTAACACAAGAGCAAGCAAACCTAACTCACCAGAAAAAGAAA; CTGGAGGGACAGATCTCAGCCCGGCAACAAGCAGAAGAAGCTTCACAGGAGTCAGAAAAC; GAACTCAAGGAAATGATAGAAACCCTTGCTCGGAAGCTGAATGAGAAATCCAAAGAGCAA; ATGGAACTTCACCACCAGAATCTGAATCTCCAAGAAACACTGAAGAGAGTAGCAAATTGT; TCAGCTCCTTGTCCGCAAGACTGGATCTGGCATGGAGAAAACTGTTACCTATTTTCCTCG; GGCTCATTTAACTGGGAAAAGAGCCAAGAGAAGTGCTTGTCTTTGGATGCCAAGTTGCTG; AAAATTAATAGCACAGCTGATCTGGACTTCATCCAGCAAGCAATTTCCTATTCCAGTTTT; CCATTCTGGATGGGGCTGTCTCGGAGGAACCCCAGCTACCCATGGCTCTGGGAGGACGGT; TCTCCTTTGATGCCCCACTTATTTAGAGTCCGAGGCGCTGTCTCCCAGACATACCCTTCA; GGTACCTGTGCATATATACAACGAGGAGCTGTTTATGCGGAAAACTGCATTTTAGCTGCC; TTCAGTATATGTCAGAAGAAGGCAAACCTAAGAGCACAGTGA; ; Clone variation with respect to NM_002543.3;
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_002543 unedited; NGTTCGGGATTTTGTAATACGACTTACTATAGGCGGCCGCGNAATTCGCACGAGGCTGCT; TCACTCTCTCATTCTTAGCTTGAATTTGGAAATGACTTTTGATGACCTAAAGATCCAGAC; TGTGAAGGACCAGCCTGATGAGAAGTCAAATGGGAAAAAAAGCTAAAGGTCTTCAGTTTC; TTTACTCTCCATGGTGGTGCCTGGCTGCTGCGACTCTAGGGGTCCTTTGCCTGGGATTAG; TAGTGACCATTATGGTGCTGGGCATGCAATTATCCCAGGTGTCTGACCTCCTAACACAAG; AGCAAGCAAACCTAACTCACCAGAAAAAGAAACTGGAGGGACAGATCTCAGCCCGGCAAC; AAGCAGAAGAAGCTTCACAGGAGTCAGAAAACGAACTCAAGGAAATGATAGAAACCCTTG; CTCGGAAGCTGAATGAGAAATCCAAAGAGCAAATGGAACTTCACCACCAGAATCTGAATC; TCCAAGAAACACTGAAGAGAGTAGCAAATTGTTCAGCTCCTTGTCCGCAAGACTGGATCT; GGCATGGAGAAAACTGTTACCTATTTTCCTCGGGCTCATTTAACTGGGAAAAGAGCCAAG; AGAAGTGCTTGTCTTTGGATGCCAAGTTGCTGAAAATTAATAGCACAGCTGATCTGGACT; TCATCCAGCAAGCAATTTCCTATTCCAGTTTTCCATTCTGGATGGGGCTGTCTCGGAGGA; ACCCCAGCTACCCATGGCTCTGGGAGGACGGTTCTCCTTTGATGCCCCACTTATTAGAGT; CCGAGGCGCTGTCTNCCCAAAATACCCTTCAGGTACCTGTGCATATATACAACGAGGAGC; TGTTTATGCCGAAAACTGCCATTTAGCTGCCTTCAGTATATGTCAGAAAGAGGCNANACC; TAGNAGCCCAGTGATTT;
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_002543 unedited; ACCGCGGCCGCAATCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT; TTTTTTTTTTTTTGGACCCAAATGTTCACAACAGCTTTTTTTGTAATATCCCAAAACTAA; AACAACCCCAATGTCCTCAACAAGTAAATGGGGAAAAGAATTGGGGGTTTTCCCTACCAG; GGAATATTCAACATTTAAAAAAATGAATTCCTTCCACCCTTAAAATGGGGACCTTTGAAT; CTCAAAATAATTATGCCAAGGGAAAAAAGCCCCACCAAAAAAAAAAACCTTCTTTTTGAT; TCCCTTCCCCTAAAACTTCCAAATGCCAAATGAAAGCCCATTGGGGGGTTTTTGGGGGGG; AGTCCTCAGGAGGAGCCTTGGGACCCTTTGAGGGATGAAGGATATGTTCACTCTCTTAAT; TGGAGGATGCATGTTCTCCACAAGGGGGGAAAACTTATCAAATAGTACACTTTAAATATG; TTCAGGTTATTTTATGGTAATTATATCTCAATAAAGCTTTTAACAAAAGCAAACATTTTT; TGCCTACATAAGGATGACACAACTCTTAAAAAAAAAAAAAAAATTTCTGCTATATTGGGT; GCACCAAAATAAAAAGGGTTCCCTTAAAGTAAAAAACCCCGTGGAGAATGGGTGGAAAGG; AATAAAAACCCTAAAAATAAAAAAAATATTTCTAAATCCCTCTGGTTTTTATTAACCGAA; TTTGCCTACCTGCCTCAATTTGTCTAAAAGGAGGGCCTCCTTTTTTTTTGCCTGGAAGGT; GCCGAATTTTACCTACCCAACCAAGTTGGAAAATCTCTTCTCCAAGGTGTTTTTTTTAGG; GAAAAAATTTATTTTACCTTTGGGCCCACATCCATGTTTTAACAAAATGTGGGAAGGGGT; AAACCTTAAATTGCCCTCGGAGAAAAAAAAGAG;
• Restriction Sites: NotI-NotI
• ACCN: NM_002543
• Insert Size: 2600 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_002543.2, NP_002534.1
• RefSeq Size: 2476 bp
• RefSeq ORF: 822 bp
• Locus ID: 4973
• UniProt ID: P78380
• Cytogenetics: 12p13.2
• Domains: CLECT
• Protein Families: Druggable Genome, Secreted Protein, Transmembrane
• Protein Pathways: PPAR signaling pathway
• Summary: This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]; Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).