FKBP51 (FKBP5) (NM_004117) Human Untagged Clone

CAT#: SC117569

FKBP5 (untagged)-Human FK506 binding protein 5 (FKBP5), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: FKBP51
• Synonyms: AIG6; FKBP51; FKBP54; P54; PPIase; Ptg-10
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC117569 sequence for NM_004117 edited (data generated by NextGen Sequencing)
  ATGACTACTGATGAAGGTGCCAAGAACAATGAAGAAAGCCCCACAGCCACTGTTGCTGAG
  CAGGGAGAGGATATTACCTCCAAAAAAGACAGGGGAGTATTAAAGATTGTCAAAAGAGTG
  GGGAATGGTGAGGAAACGCCGATGATTGGAGACAAAGTTTATGTCCATTACAAAGGAAAA
  TTGTCAAATGGAAAGAAGTTCGATTCCAGTCATGATAGAAATGAACCATTTGTCTTTAGT
  CTTGGCAAAGGCCAAGTCATCAAGGCATGGGACATTGGGGTGGCTACCATGAAGAAAGGA
  GAGATATGCCATTTACTGTGCAAACCAGAATATGCATATGGCTCGGCTGGCAGTCTCCCT
  AAAATTCCCTCGAATGCAACTCTCTTTTTTGAGATTGAGCTCCTTGATTTCAAAGGAGAG
  GATTTATTTGAAGATGGAGGCATTATCCGGAGAACCAAACGGAAAGGAGAGGGATATTCA
  AATCCAAACGAAGGAGCAACAGTAGAAATCCACCTGGAAGGCCGCTGTGGTGGAAGGATG
  TTTGACTGCAGAGATGTGGCATTCACTGTGGGCGAAGGAGAAGACCACGACATTCCAATT
  GGAATTGACAAAGCTCTGGAGAAAATGCAGCGGGAAGAACAATGTATTTTATATCTTGGA
  CCAAGATATGGTTTTGGAGAGGCAGGGAAGCCTAAATTTGGCATTGAACCTAATGCTGAG
  CTTATATATGAAGTTACACTTAAGAGCTTCGAAAAGGCCAAAGAATCCTGGGAGATGGAT
  ACCAAAGAAAAATTGGAGCAGGCTGCCATTGTCAAAGAGAAGGGAACCGTATACTTCAAG
  GGAGGCAAATACATGCAGGCGGTGATTCAGTATGGGAAGATAGTGTCCTGGTTAGAGATG
  GAATATGGTTTATCAGAAAAGGAATCGAAAGCTTCTGAATCATTTCTCCTTGCTGCCTTT
  CTGAACCTGGCCATGTGCTACCTGAAGCTTAGAGAATACACCAAAGCTGTTGAATGCTGT
  GACAAGGCCCTTGGACTGGACAGTGCCAATGAGAAAGGCTTGTATAGGAGGGGTGAAGCC
  CAGCTGCTCATGAACGAGTTTGAGTCAGCCAAGGGTGACTTTGAGAAAGTGCTGGAAGTA
  AACCCCCAGAATAAGGCTGCAAGACTGCAGATCTCCATGTGCCAGAAAAAGGCCAAGGAG
  CACAACGAGCGGGACCGCAGGATATACGCCAACATGTTCAAGAAGTTTGCAGAGCAGGAT
  GCCAAGGAAGAGGCCAATAAAGCAATGGGCAAGAAGACTTCAGAAGGGGTCACTAATGAA
  AAAGGAACAGACAGTCAAGCAATGGAAGAAGAGAAACCTGAGGGCCACGTATGA
  
  Clone variation with respect to NM_004117.3
  201 t=>c
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_004117 unedited
  GGNCGGCACGCGCAATTCGGCACGAGGCCGGCGCGCGGGCGGCCTGCTGGGCGGGCTGAA
  GGGTTAGCGGAGCACGGGCAAGGCGGAGAGTGACGGAGTCGGCGAGCCCCCGCGGCGACA
  GGTTCTCTACTTAAAAGACAATGACTACTGATGAAGGTGCCAAGAACAATGAAGAAAGCC
  CCACAGCCTCTGTTGCTGAGCAGGGAGAGGATATTACCTCCAAAAAAGACAGGGGAGTAT
  TAAAGATTGTCAAAAGAGTGGGGAATGGTGAGGAAACGCCGATGATTGGAGACAAAGTTT
  ATGTCCATTACAAAGGAAAATTGTCAAATGGAAAGAAGTTCGATTCCAGTCATGATAGAA
  ATGAACCATTTGTCTTTAGTCTTGGCAAAGGCCAAGTCATCAAGGCATGGGACATTGGGG
  TGGCTACCATGAAGAAAGGAGAGATATGCCATTTACTGTGCAAACCAGAATATGCATATG
  GCTCGGCTGGCAGTCTCCCTAAAATTCCCTCGAATGCAACTCTCTTTTTTGAGATTGAGC
  TCCTTGATTTCAAAGGAGAGGATTTATTTGAAGATGGAGGCATTATCCGGAGAACCAAAC
  GGATAGGAGAGGGATATTCAAATCCAAACGAAGGAGCAACAGTAGAAATCCACCTGGAAT
  GCCGCTGTGGTGGAAGGATGTTTGACTGCAGAGATGTGGCATTCACTGTGGGCGATAGAG
  AATGACCACGACATTCCAATTTGGAATTTGACAAGCTCTGGAGAAAATGCAGNCGGGNAG
  AACAATGTATTTTATATCTTGGACCAAGATATGGTTTTTNAGAAGCAGGNAAGCCTTAAT
  TTGGCATGGACCCTATGCTGAGCTATTTTGAAGTACACTTAAGACTTCGAAAAGCCAAA
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_004117 unedited
  CTATGGCACGCGGCACGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTGGGAAGTACA
  TTTTTTTTGGATTTATTTAAAGAACACACAAAAAAGTGCATCTAAATGATTTTTTTTTTT
  AAAAAACAATGTCTTTAATTCCTCATATGCTGACTTGGCAATCCATATGCAGCCTAAAAG
  GTGGTTGAAAGATGTCTGTGGACTTCTACACAAATTGTTTAAGATTATTGAATTTGATAC
  AAGAATACGTGAAGTGTCTTCTTGAGTGGTAATGGGCACCCTGTAGTTATTTGCTCAAAA
  CCACTCACACACCCTTCCCCTCCCCACACACACTTTTGCCAGTTCCCCCTGGTGAACCAT
  AATACACACGTGGGAGACAGCTGGCATCATCTGAGTCTTGGAATAGCTTTCTTGTTTGTT
  ATCTGCAAAAAGCTAGGTGGCCTTTTTAGTATCAAATTTCAATCTTGGCCTCACTGGAAC
  CATGCTCTACAGAGCTTTCCCAACAGTTTAGCAAGTAAGCAAAATCAGCTTTTGCTCTTC
  ATATTTCGTAGGTGAGACTGGGGCTTTTAAAAGAAATATTTCATAAAAAAGACAAAAGCC
  TAAATGAGAAATTAGAGGGATTTTAGTTATCATTAAAGGAAAAAACTCACAAATTGATCC
  CATTTGTTCCATGGGGAAGAAAAGTATTATAAAAGGAAATAACTTGATTTTTAGGTTTGA
  AGGGGGTCCCAATCTAATAATAAAAGTCTTTTGATAAAACCATCATCAAAATAAAAACTA
  ATTTAAAATATAACTGCCAGTGTTTTTTAAGATTTAAAAAGGTGAGATGTTCCCAGTTTA
  AAGCAATGGNTNCTTTGGNNTGCANATGCATTCCATGAGTGTTNCTTAAGCTGAGGAATA
  GAGAGCATGCTCATCTGTTTACCGCTAGACTGNANTCACTACTGTCACATTTAGACTTGC
  CTATTCATGTCACTCAGTACTGAGATT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_004117
• Insert Size: 3780 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_004117.2, NP_004108.1
• RefSeq Size: 3781 bp
• RefSeq ORF: 1374 bp
• Locus ID: 2289
• UniProt ID: Q13451
• Cytogenetics: 6p21.31
• Domains: FKBP, TPR
• Protein Families: Druggable Genome
• Gene Summary: The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
  Transcript Variant: This variant (1) represents the shortest transcript and encodes the longer isoform (1). Variants 1, 2 and 3 encode the same isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.