FKBP51 (FKBP5) (NM_004117) Human Untagged Clone

SKU SC117569

FKBP5 (untagged)-Human FK506 binding protein 5 (FKBP5), transcript variant 1

Product Data

• Type: Human Untagged Clone
• Target Symbol: FKBP51
• Synonyms: AIG6; FKBP51; FKBP54; P54; PPIase; Ptg-10
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF within SC117569 sequence for NM_004117 edited (data generated by NextGen Sequencing); ATGACTACTGATGAAGGTGCCAAGAACAATGAAGAAAGCCCCACAGCCACTGTTGCTGAG; CAGGGAGAGGATATTACCTCCAAAAAAGACAGGGGAGTATTAAAGATTGTCAAAAGAGTG; GGGAATGGTGAGGAAACGCCGATGATTGGAGACAAAGTTTATGTCCATTACAAAGGAAAA; TTGTCAAATGGAAAGAAGTTCGATTCCAGTCATGATAGAAATGAACCATTTGTCTTTAGT; CTTGGCAAAGGCCAAGTCATCAAGGCATGGGACATTGGGGTGGCTACCATGAAGAAAGGA; GAGATATGCCATTTACTGTGCAAACCAGAATATGCATATGGCTCGGCTGGCAGTCTCCCT; AAAATTCCCTCGAATGCAACTCTCTTTTTTGAGATTGAGCTCCTTGATTTCAAAGGAGAG; GATTTATTTGAAGATGGAGGCATTATCCGGAGAACCAAACGGAAAGGAGAGGGATATTCA; AATCCAAACGAAGGAGCAACAGTAGAAATCCACCTGGAAGGCCGCTGTGGTGGAAGGATG; TTTGACTGCAGAGATGTGGCATTCACTGTGGGCGAAGGAGAAGACCACGACATTCCAATT; GGAATTGACAAAGCTCTGGAGAAAATGCAGCGGGAAGAACAATGTATTTTATATCTTGGA; CCAAGATATGGTTTTGGAGAGGCAGGGAAGCCTAAATTTGGCATTGAACCTAATGCTGAG; CTTATATATGAAGTTACACTTAAGAGCTTCGAAAAGGCCAAAGAATCCTGGGAGATGGAT; ACCAAAGAAAAATTGGAGCAGGCTGCCATTGTCAAAGAGAAGGGAACCGTATACTTCAAG; GGAGGCAAATACATGCAGGCGGTGATTCAGTATGGGAAGATAGTGTCCTGGTTAGAGATG; GAATATGGTTTATCAGAAAAGGAATCGAAAGCTTCTGAATCATTTCTCCTTGCTGCCTTT; CTGAACCTGGCCATGTGCTACCTGAAGCTTAGAGAATACACCAAAGCTGTTGAATGCTGT; GACAAGGCCCTTGGACTGGACAGTGCCAATGAGAAAGGCTTGTATAGGAGGGGTGAAGCC; CAGCTGCTCATGAACGAGTTTGAGTCAGCCAAGGGTGACTTTGAGAAAGTGCTGGAAGTA; AACCCCCAGAATAAGGCTGCAAGACTGCAGATCTCCATGTGCCAGAAAAAGGCCAAGGAG; CACAACGAGCGGGACCGCAGGATATACGCCAACATGTTCAAGAAGTTTGCAGAGCAGGAT; GCCAAGGAAGAGGCCAATAAAGCAATGGGCAAGAAGACTTCAGAAGGGGTCACTAATGAA; AAAGGAACAGACAGTCAAGCAATGGAAGAAGAGAAACCTGAGGGCCACGTATGA; ; Clone variation with respect to NM_004117.3; 201 t=>c
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_004117 unedited; GGNCGGCACGCGCAATTCGGCACGAGGCCGGCGCGCGGGCGGCCTGCTGGGCGGGCTGAA; GGGTTAGCGGAGCACGGGCAAGGCGGAGAGTGACGGAGTCGGCGAGCCCCCGCGGCGACA; GGTTCTCTACTTAAAAGACAATGACTACTGATGAAGGTGCCAAGAACAATGAAGAAAGCC; CCACAGCCTCTGTTGCTGAGCAGGGAGAGGATATTACCTCCAAAAAAGACAGGGGAGTAT; TAAAGATTGTCAAAAGAGTGGGGAATGGTGAGGAAACGCCGATGATTGGAGACAAAGTTT; ATGTCCATTACAAAGGAAAATTGTCAAATGGAAAGAAGTTCGATTCCAGTCATGATAGAA; ATGAACCATTTGTCTTTAGTCTTGGCAAAGGCCAAGTCATCAAGGCATGGGACATTGGGG; TGGCTACCATGAAGAAAGGAGAGATATGCCATTTACTGTGCAAACCAGAATATGCATATG; GCTCGGCTGGCAGTCTCCCTAAAATTCCCTCGAATGCAACTCTCTTTTTTGAGATTGAGC; TCCTTGATTTCAAAGGAGAGGATTTATTTGAAGATGGAGGCATTATCCGGAGAACCAAAC; GGATAGGAGAGGGATATTCAAATCCAAACGAAGGAGCAACAGTAGAAATCCACCTGGAAT; GCCGCTGTGGTGGAAGGATGTTTGACTGCAGAGATGTGGCATTCACTGTGGGCGATAGAG; AATGACCACGACATTCCAATTTGGAATTTGACAAGCTCTGGAGAAAATGCAGNCGGGNAG; AACAATGTATTTTATATCTTGGACCAAGATATGGTTTTTNAGAAGCAGGNAAGCCTTAAT; TTGGCATGGACCCTATGCTGAGCTATTTTGAAGTACACTTAAGACTTCGAAAAGCCAAA;
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_004117 unedited; CTATGGCACGCGGCACGCAATCTAGGATCGAGTTTTTTTTTTTTTTTTTTGGGAAGTACA; TTTTTTTTGGATTTATTTAAAGAACACACAAAAAAGTGCATCTAAATGATTTTTTTTTTT; AAAAAACAATGTCTTTAATTCCTCATATGCTGACTTGGCAATCCATATGCAGCCTAAAAG; GTGGTTGAAAGATGTCTGTGGACTTCTACACAAATTGTTTAAGATTATTGAATTTGATAC; AAGAATACGTGAAGTGTCTTCTTGAGTGGTAATGGGCACCCTGTAGTTATTTGCTCAAAA; CCACTCACACACCCTTCCCCTCCCCACACACACTTTTGCCAGTTCCCCCTGGTGAACCAT; AATACACACGTGGGAGACAGCTGGCATCATCTGAGTCTTGGAATAGCTTTCTTGTTTGTT; ATCTGCAAAAAGCTAGGTGGCCTTTTTAGTATCAAATTTCAATCTTGGCCTCACTGGAAC; CATGCTCTACAGAGCTTTCCCAACAGTTTAGCAAGTAAGCAAAATCAGCTTTTGCTCTTC; ATATTTCGTAGGTGAGACTGGGGCTTTTAAAAGAAATATTTCATAAAAAAGACAAAAGCC; TAAATGAGAAATTAGAGGGATTTTAGTTATCATTAAAGGAAAAAACTCACAAATTGATCC; CATTTGTTCCATGGGGAAGAAAAGTATTATAAAAGGAAATAACTTGATTTTTAGGTTTGA; AGGGGGTCCCAATCTAATAATAAAAGTCTTTTGATAAAACCATCATCAAAATAAAAACTA; ATTTAAAATATAACTGCCAGTGTTTTTTAAGATTTAAAAAGGTGAGATGTTCCCAGTTTA; AAGCAATGGNTNCTTTGGNNTGCANATGCATTCCATGAGTGTTNCTTAAGCTGAGGAATA; GAGAGCATGCTCATCTGTTTACCGCTAGACTGNANTCACTACTGTCACATTTAGACTTGC; CTATTCATGTCACTCAGTACTGAGATT;
• Restriction Sites: NotI-NotI
• ACCN: NM_004117
• Insert Size: 3780 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_004117.2, NP_004108.1
• RefSeq Size: 3781 bp
• RefSeq ORF: 1374 bp
• Locus ID: 2289
• UniProt ID: Q13451
• Cytogenetics: 6p21.31
• Domains: FKBP, TPR
• Protein Families: Druggable Genome
• Summary: The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]; Transcript Variant: This variant (1) represents the shortest transcript and encodes the longer isoform (1). Variants 1, 2 and 3 encode the same isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.