BMPR2 (NM_001204) Human Untagged Clone

CAT#: SC108987

BMPR2 (untagged)-Human bone morphogenetic protein receptor, type II (serine/threonine kinase) (BMPR2)

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: BMPR2
• Synonyms: BMPR-II; BMPR3; BMR2; BRK-3; POVD1; PPH1; T-ALK
• Vector: pCMV6-XL5
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene ORF sequence for NM_001204 edited
  ATGACTTCCTCGCTGCAGCGGCCCTGGCGGGTGCCCTGGCTACCATGGACCATCCTGCTG
  GTCAGCGCTGCGGCTGCTTCGCAGAATCAAGAACGGCTATGTGCGTTTAAAGATCCGTAT
  CAGCAAGACCTTGGGATAGGTGAGAGTAGAATCTCTCATGAAAATGGGACAATATTATGC
  TCGAAAGGTAGCACCTGCTATGGCCTTTGGGAGAAATCAAAAGGGGACATAAATCTTGTA
  AAACAAGGATGTTGGTCTCACATTGGAGATCCCCAAGAGTGTCACTATGAAGAATGTGTA
  GTAACTACCACTCCTCCCTCAATTCAGAATGGAACATACCGTTTCTGCTGTTGTAGCACA
  GATTTATGTAATGTCAACTTTACTGAGAATTTTCCACCTCCTGACACAACACCACTCAGT
  CCACCTCATTCATTTAACCGAGATGAGACAATAATCATTGCTTTGGCATCAGTCTCTGTA
  TTAGCTGTTTTGATAGTTGCCTTATGCTTTGGATACAGAATGTTGACAGGAGACCGTAAA
  CAAGGTCTTCACAGTATGAACATGATGGAGGCAGCAGCATCCGAACCCTCTCTTGATCTA
  GATAATCTGAAACTGTTGGAGCTGATTGGCCGAGGTCGATATGGAGCAGTATATAAAGGC
  TCCTTGGATGAGCGTCCAGTTGCTGTAAAAGTGTTTTCCTTTGCAAACCGTCAGAATTTT
  ATCAACGAAAAGAACATTTACAGAGTGCCTTTGATGGAACATGACAACATTGCCCGCTTT
  ATAGTTGGAGATGAGAGAGTCACTGCAGATGGACGCATGGAATATTTGCTTGTGATGGAG
  TACTATCCCAATGGATCTTTATGCAAGTATTTAAGTCTCCACACAAGTGACTGGGTAAGC
  TCTTGCCGTCTTGCTCATTCTGTTACTAGAGGACTGGCTTATCTTCACACAGAATTACCA
  CGAGGAGATCATTATAAACCTGCAATTTCCCATCGAGATTTAAACAGCAGAAATGTCCTA
  GTGAAAAATGATGGAACCTGTGTTATTAGTGACTTTGGACTGTCCATGAGGCTGACTGGA
  AATAGACTGGTGCGCCCAGGGGAGGAAGATAATGCAGCCATAAGCGAGGTTGGCACTATC
  AGATATATGGCACCAGAAGTGCTAGAAGGAGCTGTGAACTTGAGGGACTGTGAATCAGCT
  TTGAAACAAGTAGACATGTATGCTCTTGGACTAATCTATTGGGAGATATTTATGAGATGT
  ACAGACCTCTTCCCAGGGGAATCCGTACCAGAGTACCAGATGGCTTTTCAGACAGAGGTT
  GGAAACCATCCCACTTTTGAGGATATGCAGGTTCTCGTGTCTAGGGAAAAACAGAGACCC
  AAGTTCCCAGAAGCCTGGAAAGAAAATAGCCTGGCAGTGAGGTCACTCAAGGAGACAATC
  GAAGACTGTTGGGACCAGGATGCAGAGGCTCGGCTTACTGCACAGTGTGCTGAGGAAAGG
  ATGGCTGAACTTATGATGATTTGGGAAAGAAACAAATCTGTGAGCCCAACAGTCAATCCA
  ATGTCTACTGCTATGCAGAATGAACGCAACCTGTCACATAATAGGCGTGTGCCAAAAATT
  GGTCCTTATCCAGATTATTCTTCCTCCTCATACATTGAAGACTCTATCCATCATACTGAC
  AGCATCGTGAAGAATATTTCCTCTGAGCATTCTATGTCCAGCACACCTTTGACTATAGGG
  GAAAAAAACCGAAATTCAATTAACTATGAACGACAGCAAGCACAAGCTCGAATCCCCAGC
  CCTGAAACAAGTGTCACCAGCCTCTCCACCAACACAACAACCACAAACACCACAGGACTC
  ACGCCAAGTACTGGCATGACTACTATATCTGAGATGCCATACCCAGATGAAACAAATCTG
  CATACCACAAATGTTGCACAGTCAATTGGGCCAACCCCTGTCTGCTTACAGCTGACAGAA
  GAAGACTTGGAAACCAACAAGCTAGACCCAAAAGAAGTTGATAAGAACCTCAAGGAAAGC
  TCTGATGAGAATCTCATGGAGCACTCTCTTAAACAGTTCAGTGGCCCAGACCCACTGAGC
  AGTACTAGTTCTAGCTTGCTTTACCCACTCATAAAACTTGCAGTAGAAGCAACTGGACAG
  CAGGACTTCACACAGACTGCAAATGGCCAAGCATGTTTGATTCCTGATGTTCTGCCTACT
  CAGATCTATCCTCTCCCCAAGCAGCAGAACCTTCCCAAGAGACCTACTAGTTTGCCTTTG
  AACACCAAAAATTCAACAAAAGAGCCCCGGCTAAAATTTGGCAGCAAGCACAAATCAAAC
  TTGAAACAAGTCGAAACTGGAGTTGCCAAGATGAATACAATCAATGCAGCAGAACCTCAT
  GTGGTGACAGTCACCATGAATGGTGTGGCAGGTAGAAACCACAGTGTTAACTCCCATGCT
  GCCACAACCCAATATGCCAATGGGACAGTACTATCTGGCCAAACAACCAACATAGTGACA
  CATAGGGCCCAAGAAATGTTGCAGAATCAGTTTATTGGTGAGGACACCCGGCTGAATATT
  AATTCCAGTCCTGATGAGCATGAGCCTTTACTGAGACGAGAGCAACAAGCTGGCCATGAT
  GAAGGTGTTCTGGATCGTCTTGTGGACAGGAGGGAACGGCCACTAGAAGGTGGCCGAACT
  AATTCCAATAACAACAACAGCAATCCATGTTCAGAACAAGATGTTCTTGCACAGGGTGTT
  CCAAGCACAGCAGCAGATCCTGGGCCATCAAAGCCCAGAAGAGCACAGAGGCCTAATTCT
  CTGGATCTTTCAGCCACAAATGTCCTGGATGGCAGCAGTATACAGATAGGTGAGTCAACA
  CAAGATGGCAAATCAGGATCAGGTGAAAAGATCAAGAAACGTGTGAAAACTCCCTATTCT
  CTTAAGCGGTGGCGCCCCTCCACCTGGGTCATCTCCACTGAATCGCTGGACTGTGAAGTC
  AACAATAATGGCAGTAACAGGGCAGTTCATTCCAAATCCAGCACTGCTGTTTACCTTGCA
  GAAGGAGGCACTGCTACAACCATGGTGTCTAAAGATATAGGAATGAACTGTCTGTGA
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_001204 unedited
  CCAATTCCCTCGAGGGTGAAGGAAGTCCCGAAGCGAAACTTAAGGAATCCTGCCTTCCCG
  GAGCCGCGGGCGATGCGACTAGGGCTGCCGGGCGCCGCCGCCGCCCGTCCGGCTTCGTCC
  TTCCCGGCAGTCGGGAACTAGTTCTGACCCTCGCCCCCCGACCCCGGATCGATANCCTTG
  CTCTCCGCACCCTGGATATGTTTTCTCCCAGACCTGGATATTTTTTTGATATCGTGAAAC
  TACGAGGGAAATAATTTGGGGGATTTCTTCTTGGCTCCCTGCTTTCCCCACAGACATGCC
  TTCCGTTTGGAGGGCCGCGGCACCCCGTCCGAGGCGAAGGAACCCCCCCAGCCGCGAGGG
  AGAGAAATGAAGGGAATTTCTGCAGCGGCATGAAAGCTCTGCAGCTAGGTCCTCTCATCA
  GCCATTTGTCCTTTCAAACTGTATTGTGATACGGGCAGGATCAGTCCACGGGAGAGAAGA
  CGAGCCTCCCGGCTGTTTCTCCGCCGGTCTACTTCCCATATTTCTTTTCTTTGCCCTCCT
  GATTCTTGGCTGGCCCAGGGATGACTTCCTCGCTGCAGCGGCCCTGGCGGGTGCCCTGGC
  TACCATGGACCATCCTGCTGGTCAGCGCTGCGGCTGCTTCGCAGAATCAAGAACGGCTAT
  GTGCGTTTAAAGATCCGTATCAGCAAGACCCTTGGATAGGTGAGAGTAGAATCTCTCATN
  GAAATGGGACAATATTATGCTCGAAAGGTAGCACCTGCTATGGGCCTTGGGAGAAATCAA
  AAGGGACATAAATCTTGTAAACAGGGATGTTGGTCTCACATTTGGAGATCCCAAGAGTGT
  CCCTTTGAAAATGTGTAGTAACTACCCT
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_001204 unedited
  NTCCCCCCCCCCGGTCCNCCGCCGCCCCCCTCCCCCNCCNNTCCTCCGCCTCTGCTCCGC
  GGCCCGGCATCTAGCATCGAGTTTTTTTTTTTTTTTTTTAAACATCTTCTGCATGTTTAA
  ATGATGCAAAAAAAATTTCACTCCATAGGCTTGAAAACATTTCACAGACAGTTCATTCCT
  ATATCTTTAGACACCATGGTTGTAGCAGTGCCTCCTTCTGCAAGGTAAACAGCAGCGCTG
  GATTTGGAATGAACTGCCCTGTTACTGCCATTATTGTTGACTTCACAGTCCAGCGATTCA
  GTGGAGATGACCCAGGTGGAGGGGCGCCACCGCTTAAGAGAATAGGGAGTTTTCACACGT
  TTCTTGATCTTTTCACCTGATCCTGATTTGCCATCTTGTGTTGACTCACCTATCTGTATA
  CTGCTGCCATCCAGGACATTTGTGGCTGAAAGATCCAGAGAATTAGGCCTCTGTGCTCTT
  CTGGGCTTTGATGGCCCAGGATCTGCTGCTGTGCTTGGAACACCCTGTGCAAGAACATCT
  TGCCCTGAACATGGATTGCTGTTGTTGTTATTGGAATTAGTTCGGCCACCTTCTAGTTGG
  CCGCTCCCTCCTGTCCACAAGACGATCCAGAACACCTTCATCATGGCCAGNTTGNTGCTC
  TCGTCTCAGTAAAGGCTCATGCTCATCAGGACTGTGATTCATACTCACCCCGTGTGTCCT
  TACCAATAAACTGATTCTCGAACATTTCTTGGCCCTTATGTGTCACTATGTTCGGTGCTT
  GGCCAGACACTACCGGCCCATTGCACATTGGGTTCGGGCCCATGGCACTTACCACTGTGG
  CTTCTACCTGCCACACCATCCTGGGGACTGCCACACAAGAGGCTTTGTGCATTGATTGGT
  TTTATTTGGGCACCTCAGTTCCACTTGTTTAAGGTT
  
• Restriction Sites: NotI-NotI
• ACCN: NM_001204
• Insert Size: 3670 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_001204.5, NP_001195.2
• RefSeq Size: 11449 bp
• RefSeq ORF: 3117 bp
• Locus ID: 659
• UniProt ID: Q13873
• Cytogenetics: 2q33.1-q33.2
• Domains: Activin_recp, pkinase, TyrKc, S_TKc
• Protein Families: Druggable Genome, Protein Kinase, Transmembrane
• Protein Pathways: Cytokine-cytokine receptor interaction, TGF-beta signaling pathway
• Gene Summary: This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this receptor are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of two different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Mutations in this gene have been associated with primary pulmonary hypertension, both familial and fenfluramine-associated, and with pulmonary venoocclusive disease. [provided by RefSeq, May 2020]
  Transcript Variant: This variant (1) encodes the full length isoform. Isoform 1 is 508 aa longer than isoform 2 and includes a long cytoplasmic tail unique to this bone morphogenetic protein type II receptor.