STAT2 (NM_005419) Human Untagged Clone

CAT#: SC108848

STAT2 (untagged)-Human signal transducer and activator of transcription 2, 113kDa (STAT2), transcript variant 1

Specifications

Product Data

• Type: Human Untagged Clone
• Tag: Tag Free
• Symbol: STAT2
• Synonyms: IMD44; ISGF-3; P113; PTORCH3; STAT113
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_005419, the custom clone sequence may differ by one or more nucleotides
  
  
  ATGGCGCAGTGGGAAATGCTGCAGAATCTTGACAGCCCCTTTCAGGATCAGCTGCACCAGCTTTACTCGC
  ACAGCCTCCTGCCTGTGGACATTCGACAGTACTTGGCTGTCTGGATTGAAGACCAGAACTGGCAGGAAGC
  TGCACTTGGGAGTGATGATTCCAAGGCTACCATGCTATTCTTCCACTTCTTGGATCAGCTGAACTATGAG
  TGTGGCCGTTGCAGCCAGGACCCAGAGTCCTTGTTGCTGCAGCACAATTTGCGGAAATTCTGCCGGGACA
  TTCAGCCCTTTTCCCAGGATCCTACCCAGTTGGCTGAGATGATCTTTAACCTCCTTCTGGAAGAAAAAAG
  AATTTTGATCCAGGCTCAGAGGGCCCAATTGGAACAAGGAGAGCCAGTTCTCGAAACACCTGTGGAGAGC
  CAGCAACATGAGATTGAATCCCGGATCCTGGATTTAAGGGCTATGATGGAGAAGCTGGTAAAATCCATCA
  GCCAACTGAAAGACCAGCAGGATGTCTTCTGCTTCCGATATAAGATCCAGGCCAAAGGGAAGACACCCTC
  TCTGGACCCCCATCAGACCAAAGAGCAGAAGATTCTGCAGGAAACTCTCAATGAACTGGACAAAAGGAGA
  AAGGAGGTGCTGGATGCCTCCAAAGCACTGCTAGGCCGATTAACTACCCTAATCGAGCTACTGCTGCCAA
  AGTTGGAGGAGTGGAAGGCCCAGCAGCAAAAAGCCTGCATCAGAGCTCCCATTGACCACGGGTTGGAACA
  GCTGGAGACATGGTTCACAGCTGGAGCAAAGCTGTTGTTTCACCTGAGGCAGCTGCTGAAGGAGCTGAAG
  GGACTGAGTTGCCTGGTTAGCTATCAGGATGACCCTCTGACCAAAGGGGTGGACCTACGCAACGCCCAGG
  TCACAGAGTTGCTACAGCGTCTGCTCCACAGAGCCTTTGTGGTAGAAACCCAGCCCTGCATGCCCCAAAC
  TCCCCATCGACCCCTCATCCTCAAGACTGGCAGCAAGTTCACCGTCCGAACAAGGCTGCTGGTGAGACTC
  CAGGAAGGCAATGAGTCACTGACTGTGGAAGTCTCCATTGACAGGAATCCTCCTCAATTACAAGGCTTCC
  GGAAGTTCAACATTCTGACTTCAAACCAGAAAACTTTGACCCCCGAGAAGGGGCAGAGTCAGGGTTTGAT
  TTGGGACTTTGGTTACCTGACTCTGGTGGAGCAACGTTCAGGTGGTTCAGGAAAGGGCAGCAATAAGGGG
  CCACTAGGTGTGACAGAGGAACTGCACATCATCAGCTTCACGGTCAAATATACCTACCAGGGTCTGAAGC
  AGGAGCTGAAAACGGACACCCTCCCTGTGGTGATTATTTCCAACATGAACCAGCTCTCAATTGCCTGGGC
  TTCAGTTCTCTGGTTCAATTTGCTCAGCCCAAACCTTCAGAACCAGCAGTTCTTCTCCAACCCCCCCAAG
  GCCCCCTGGAGCTTGCTGGGCCCTGCTCTCAGTTGGCAGTTCTCCTCCTATGTTGGCCGAGGCCTCAACT
  CAGACCAGCTGAGCATGCTGAGAAACAAGCTGTTCGGGCAGAACTGTAGGACTGAGGATCCATTATTGTC
  CTGGGCTGACTTCACTAAGCGAGAGAGCCCTCCTGGCAAGTTACCATTCTGGACATGGCTGGACAAAATT
  CTGGAGTTGGTACATGACCACCTGAAGGATCTCTGGAATGATGGACGCATCATGGGCTTTGTGAGTCGGA
  GCCAGGAGCGCCGGCTGCTGAAGAAGACCATGTCTGGCACCTTTCTACTGCGCTTCAGTGAATCGTCAGA
  AGGGGGCATTACCTGCTCCTGGGTGGAGCACCAGGATGATGACAAGGTGCTCATCTACTCTGTGCAACCG
  TACACGAAGGAGGTGCTGCAGTCACTCCCGCTGACTGAAATCATCCGCCATTACCAGTTGCTCACTGAGG
  AGAATATACCTGAAAACCCACTGCGCTTCCTCTATCCCCGAATCCCCCGGGATGAAGCTTTTGGGTGCTA
  CTACCAGGAGAAAGTTAATCTCCAGGAACGGAGGAAATACCTGAAACACAGGCTCATTGTGGTCTCTAAT
  AGACAGGTGGATGAACTGCAACAACCGCTGGAGCTTAAGCCAGAGCCAGAGCTGGAGTCATTAGAGCTGG
  AACTAGGGCTGGTGCCAGAGCCAGAGCTCAGCCTGGACTTAGAGCCACTGCTGAAGGCAGGGCTGGATCT
  GGGGCCAGAGCTAGAGTCTGTGCTGGAGTCCACTCTGGAGCCTGTGATAGAGCCCACACTATGCATGGTA
  TCACAAACAGTGCCAGAGCCAGACCAAGGACCTGTATCACAGCCAGTGCCAGAGCCAGATTTGCCCTGTG
  ATCTGAGACATTTGAACACTGAGCCAATGGAAATCTTCAGAAACTGTGTAAAGATTGAAGAAATCATGCC
  GAATGGTGACCCACTGTTGGCTGGCCAGAACACCGTGGATGAGGTTTACGTCTCCCGCCCCAGCCACTTC
  TACACTGATGGACCCTTGATGCCTTCTGACTTCTAG
  
  
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_005419 unedited
  ACGTACAACATTTTGTAATACGACTCACTATTAGGGCGGCCGCGAATTCGCACGAGTTGA
  CTGAATGGCAGCCAGTGTCGGGGTGGCGGCTGGGAATGGGGGCCGCTCCGGACTTCCGCT
  GCCAACTACAAGGGGGCGGGTCCGAGGGGGGTTAGCCGAAGTTGTAGGCGGGGCGCGAGG
  TTCTAGTACCCGAGCTCATACTATGGACGGGAAGTCGCGACCAGAGCCATTGGAGGGCGC
  GGGGACTGCAACCCTAATCAGAGCCCAAATGGCGCAGTGGGAAATGCTGCAGAATCTTGA
  CAGCCCCTTTCAGGATCAGCTGCACCAGCTTTACTCGCACAGCCTCCTGCCTGTGGACAT
  TCGACAGTACTTGGCTGTCTGGATTGAAGACCAGAACTGGCAGGAAGCTGCACTTGGGAG
  TGATGATTCCAAGGCTACCATGCTATTCTTCCACTTCTTGGATCAGCTGAACTATGAGTG
  TGGCCGTTGCAGCCAGGACCCAGAGTCCTTGTTGCTGCAGCACAATTTGCGGAAATTCTG
  CCGGGACATTCAGCCCTTTTCCCAGGATCCTACCCAGTTGGCTGAGATGATCTTTAACCT
  CCTTCTGGAAGAAAAAAGAATTTTGATCCAGGCTCAGAGGGCCCAATTGGAACAAGGAGA
  GCCAGTTCTCGAAACACCTGTGGAGAGCCAGCAACATGAGATTGAATCCCGGATCCTGGA
  TTTAAGGGCTATGATGGAGAAGCTGGTAAAATCCATCAGCCAACTGAAAGACCAGCAGGA
  TGTCTTCTGCTTNCGATATAAGATCCANGCCAAAGGGAAGACACCCTCTCTGGACCCCCA
  TCAGACCANAGAGCAGAAGATTCTGCAGGATACTCTCAATGACTGGACATATGAGATAGG
  GAGTGCTGGATGCCTNCAAGCACTGCTAGGCCG
  
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_005419 unedited
  CGTAAGATCTCTTGGGCGATGGTCAACTTCCCAGTGTCCAGTGATAGGCACTGGAGGAAG
  GGGCTCACAGGGCATGCCACCCGGGTTCTGTTCAGGAAACAGCTATGACCGCGGCCGCAA
  TCTAGAGTCGAGTTTTTTTTTTTTTTTTTTTTTTCCAGATCAGCACAAAGTTTATTAGCC
  ATTTCTGCTCAAAAGAGCCCCTTTCTGAACAGGACTGTTCCTCTGACATAACAGACAAGA
  AACAGCCACCTGTGCAGGGCCTTTCCTTTATATCTCAAGCTACATCAGGAGAACATCTTG
  GAGCAATGTCAGTTGCCCCCTGGGGTTCCCTGGGAATAGCTAAGGTGTGAGATTGTCCAG
  AGTCCTATGACAGACCTTCAAGGTTTTAAGTTCCACAGACTTGGACTTTGTCCAGGTCCA
  CAACCAACGAATAGAAACCTTCCTTTCAGGTAAACAACATATTGTACAAAAAAGGGAGGA
  TGATAACATAATAGAGAAAGAGCTAAGACCCATTGCTTCTCCTCTGTAAAAACACCAAAC
  TTTATCCAATACTATAAAAAAGAAATTCCTGCTGGGAACAGTGGCTCACGCCTGTAATCC
  CAGCTCTCTGGGAGGGCAAGAGATATGAAAAGAACAGAGGAAATGTGGTTCCTAGAATTC
  AGAAGGCATCAAGGGTCCATCAGTGTAGAAGTGGCTGGGGCGGGAGACGTAAACCTCATC
  CACGGTGTTCTGGCCAGCCAACAGTGGGTCACCATTCGGCATGATTTCTTCAATCTTTAC
  ACAGTTTCTGAAGATTTCCATTGGCTCAGTGTTCAAATGTCTCATATCACAGGGCAAATC
  TGGCTCTGGGACTGGCTGTGATACAGTCCCTTGGTCTGGCTCTGGCACTGTTTGTGATAC
  CCTGCATAGTGG
  
• Restriction Sites: NotI-NotI
• ACCN: NM_005419
• Insert Size: 3200 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_005419.1, NP_005410.1
• RefSeq Size: 4576 bp
• RefSeq ORF: 2556 bp
• Locus ID: 6773
• UniProt ID: P52630
• Cytogenetics: 12q13.3
• Domains: SH2, STAT
• Protein Families: Druggable Genome, Transcription Factors
• Protein Pathways: Chemokine signaling pathway, Jak-STAT signaling pathway
• Gene Summary: The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. The protein mediates innate antiviral activity. Mutations in this gene result in Immunodeficiency 44. [provided by RefSeq, Aug 2020]
  Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).