SYVN1 (NM_172230) Human Untagged Clone

SKU SC101046

SYVN1 (untagged)-Human synovial apoptosis inhibitor 1, synoviolin (SYVN1), transcript variant 2

Product Data

• Type: Human Untagged Clone
• Target Symbol: SYVN1
• Synonyms: DER3; HRD1
• Vector: pCMV6-XL6
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >NCBI ORF sequence for NM_172230, the custom clone sequence may differ by one or more nucleotides; ; ; ATGTTCCGCACGGCAGTGATGATGGCGGCCAGCCTGGCGCTGACCGGGGCTGTGGTGGCTCACGCCTACT; ACCTCAAACACCAGTTCTACCCCACTGTGGTGTACCTGACCAAGTCCAGCCCCAGCATGGCAGTCCTGTA; CATCCAGGCCTTTGTCCTTGTCTTCCTTCTGGGCAAGGTGATGGGCAAGGTGTTCTTTGGGCAACTGAGG; GCAGCAGAGATGGAGCACCTTCTGGAACGTTCCTGGTACGCCGTCACAGAGACTTGTCTGGCCTTCACCG; TTTTTCGGGATGACTTCAGCCCCCGCTTTGTTGCACTCTTCACTCTTCTTCTCTTCCTCAAATGTTTCCA; CTGGCTGGCTGAGGACCGTGTGGACTTTATGGAACGCAGCCCCAACATCTCCTGGCTCTTTCACTGCCGC; ATTGTCTCTCTTATGTTCCTCCTGGGCATCCTGGACTTCCTCTTCGTCAGCCACGCCTATCACAGCATCC; TGACCCGTGGGGCCTCTGTGCAGCTGGTGTTTGGCTTTGAGTATGCCATCCTGATGACGATGGTGCTCAC; CATCTTCATCAAGTATGTGCTGCACTCCGTGGACCTCCAGAGTGAGAACCCCTGGGACAACAAGGCTGTG; TACATGCTCTACACAGAGCTGTTTACAGGCTTCATCAAGGTTCTGCTGTACATGGCCTTCATGACCATCA; TGATCAAGGTGCACACCTTCCCACTCTTTGCCATCCGGCCCATGTACCTGGCCATGAGACAGTTCAAGAA; AGCTGTGACAGATGCCATCATGTCTCGCCGAGCCATCCGCAACATGAACACCCTGTATCCAGATGCCACC; CCAGAGGAGCTCCAGGCAATGGACAATGTCTGCATCATCTGCCGAGAAGAGATGGTGACTGGTGCCAAGA; GACTGCCCTGCAACCACATTTTCCATACCAGCTGCCTGCGCTCCTGGTTCCAGCGGCAGCAGACCTGCCC; CACCTGCCGTATGGATGTCCTTCGTGCATCGCTGCCAGCGCAGTCACCACCACCCCCGGAGCCTGCGGAT; CAGGGGCCACCCCCTGCCCCCCACCCCCCACCACTCTTGCCTCAGCCCCCCAACTTCCCCCAGGGCCTCC; TGCCTCCTTTTCCTCCAGGCATGTTCCCACTGTGGCCCCCCATGGGCCCCTTTCCACCTGTCCCGCCTCC; CCCCAGCTCAGGAGAGGCTGTGGCTCCTCCATCCACCAGTGCAGCAGCCCTTTCTCGGCCCAGTGGAGCA; GCTACAACCACAGCTGCTGGCACCAGTGCTACTGCTGCTTCTGCCACAGCATCTGGCCCAGGCTCTGGCT; CTGCCCCAGAGGCTGGCCCTGCCCCTGGTTTCCCCTTCCCTCCTCCCTGGATGGGTATGCCCCTGCCTCC; ACCCTTTGCCTTCCCCCCAATGCCTGTGCCCCCTGCGGGCTTTGCTGGGCTGACCCCAGAGGAGCTACGA; GCTCTGGAGGGCCATGAGCGGCAGCACCTGGAGGCCCGGCTGCAGAGCCTGCGTAACATCCACACACTGC; TGGACGCCGCCATGCTGCAGATCAACCAGTACCTCACCGTGCTGGCCTCCTTGGGGCCCCCCCGGCCTGC; CACTTCAGTCAACTCCACTGAGGAGACTGCCACTACAGTTGTTGCTGCTGCCTCCTCCACCAGCATCCCT; AGCTCAGAGGCCACGACCCCAACCCCAGGAGCCTCCCCACCAGCCCCTGAAATGGAAAGGCCTCCAGCTC; CTGAGTCAGTGGGCACAGAGGAGATGCCTGAGGATGGAGAGCCCGATGCAGCAGAGCTCCGCCGGCGCCG; CCTGCAGAAGCTGGAGTCTCCTGTTGCCCACTGA; ;
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_172230 unedited; GGGGGGGNNGGGGNNNANNNNTTTNNNTTTNNNNNNNTTTTTTTCCCCCGCCCCTTGCCC; CAAAGGGCGGTAGGCGTGTACGGTGGNGAGTCTATATAAGCAGAGCTCATTTAGGTGACA; CTATAGAATACAAGCTACTTGTTCTTTTTGCAGCGGCCGCGAATTCGGCACGAGGGTTAA; CCGGAGGGGCAGCCGCAGTCGCGCGGATTGAGCGGGCTCGCGGCGCTGGGTTCCTGGTCT; CCGGGCCAGGGCAATGTTCCGCACGGCAGTGATGATGGCGGCCAGCCTGGCGCTGACCGG; GGCTGTGGTGGCTCACGCCTACTACCTCAAACACCAGTTCTACCCCACTGTGGTGTACCT; GACCAAGTCCAGCCCCAGCATGGCAGTCCTGTACATCCAGGCCTTTGTCCTTGTCTTCCT; TCTGGGCAAGGTGATGGGCAAGGTGTTCTTTGGGCAACTGAGGGCAGCAGAGATGGAGCA; CCTTCTGGAACGTTCCTGGTACGCCGTCACAGAGACTTGTCTGGCCTTCACCGTTTTTCG; GGATGACTTCAGCCCCCGCTTTGTTGCACTCTTCACTCTTCTTCTCTTCCTCAAATGTTT; CCACTGGCTGGCTGAGGACCGTGTGGACTTTATGGAACGCAGCCCCAACATCTCCTGGCT; CTTTCACTGCCGCATTGTCTCTCTTATGTTCCTCCTGGGCATCCTGGACTTCCTCTTCGT; CAGCCACGCCTATCACAGCATCCTGACCCGTGGGGCCTCTGTGCAGCTGGTGTTTGGCTT; TGAGTATGCCATCCTGATGACGATGGTGCTCACCATCTTCATCAAGTATGTGCTGCACTC; CGTGGACCTCCAGAGTGAGAACCCCTGNNGACACANGACTGTGTACATGCTCTACACAGN; AGCTGTTACAGGCTTCATCAAGNTNCTGCTGTACATGGNCCTTCTG;
• Restriction Sites: NotI-NotI
• ACCN: NM_172230
• Insert Size: 3000 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_172230.2, NP_757385.1
• RefSeq Size: 3074 bp
• RefSeq ORF: 1854 bp
• Locus ID: 84447
• UniProt ID: Q86TM6
• Cytogenetics: 11q13.1
• Protein Families: Druggable Genome, Transmembrane
• Protein Pathways: Ubiquitin mediated proteolysis
• Summary: This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms. [provided by RefSeq, May 2011]; Transcript Variant: This variant (2) uses a different splice site than variant 1 and encodes the longer isoform (b).