CNTF Receptor alpha (CNTFR) (NM_147164) Human Untagged Clone

SKU SC100275

CNTFR (untagged)-Human ciliary neurotrophic factor receptor (CNTFR), transcript variant 1

Product Data

• Type: Human Untagged Clone
• Target Symbol: CNTF Receptor alpha
• Vector: pCMV6-XL4
• E. coli Selection: Ampicillin (100 ug/mL)
• Mammalian Cell Selection: None
• Sequence Data:
  Fully Sequenced ORF

  >OriGene sequence for NM_147164 edited; GAATTCGGCACGAGGGGCGGCGGCAGCGGAGGCGGCGGCTCCAGCCGGCGCGGCGCGAGG; CTCGGCGGTGGGATCCGGCGGGCGGTGCTAGCTCCGCGCTCCCTGCCTCGCTCGCTGCCG; GGGGCGGTCGGAAGGCGCGGCGCGAAGCCCGGGTGGCCCGAGGGCGCGACTCTAGCCTTG; TCACCTCATCTTGCCCCCTTGGTTTTGGAAGTCCTGAAGAGTTGGTCTGGAGGAGGAGGA; GGACATTGATGTGCTTGGTGTGTGGCCAGTGGTGAAGAGATGGCTGCTCCTGTCCCGTGG; GCCTGCTGTGCTGTGCTTGCCGCCGCCGCCGCAGTTGTCTACGCCCAGAGACACAGTCCA; CAGGAGGCACCCCATGTGCAGTACGAGCGCCTGGGCTCTGACGTGACACTGCCATGTGGG; ACAGCAAACTGGGATGCTGCGGTGACGTGGCGGGTAAATGGGACAGACCTGGCCCCTGAC; CTGCTCAACGGCTCTCAGCTGGTGCTCCATGGCCTGGAACTGGGCCACAGTGGCCTCTAC; GCCTGCTTCCACCGTGACTCCTGGCACCTGCGCCACCAAGTCCTGCTGCATGTGGGCTTG; CCGCCGCGGGAGCCTGTGCTCAGCTGCCGCTCCAACACTTACCCCAAGGGCTTCTACTGC; AGCTGGCATCTGCCCACCCCCACCTACATTCCCAACACCTTCAATGTGACTGTGCTGCAT; GGCTCCAAAATTATGGTCTGTGAGAAGGACCCAGCCCTCAAGAACCGCTGCCACATTCGC; TACATGCACCTGTTCTCCACCATCAAGTACAAGGTCTCCATAAGTGTCAGCAATGCCCTG; GGCCACAATGCCACAGCTATCACCTTTGACGAGTTCACCATTGTGAAGCCTGATCCTCCA; GAAAATGTGGTAGCCCGGCCAGTGCCCAGCAACCCTCGCCGGCTGGAGGTGACGTGGCAG; ACCCCCTCGACCTGGCCTGACCCTGAGTCTTTTCCTCTCAAGTTCTTTCTGCGCTACCGA; CCCCTCATCCTGGACCAGTGGCAGCATGTGGAGCTGTCCGACGGCACAGCACACACCATC; ACAGATGCCTACGCCGGGAAGGAGTACATTATCCAGGTGGCAGCCAAGGACAATGAGATT; GGGACATGGAGTGACTGGAGCGTAGCCGCCCACGCTACGCCCTGGACTGAGGAACCGCGA; CACCTCACCACGGAGGCCCAGGCTGCGGAGACCACGACCAGCACCACCAGCTCCCTGGCA; CCCCCACCTACCACGAAGATCTGTGACCCTGGGGAGCTGGGCAGCGGCGGGGGACCCTCG; GCACCCTTCTTGGTCAGCGTCCCCATCACTCTGGCCCTGGCTGCCGCTGCCGCCACTGCC; AGCAGTCTCTTGATCTGAGCCCGGCACCCCATGAGGACATGCAGAGCACCTGCAGAGGAG; CAGGAGGCCGGAGCTGAGCCTGCAGACCCCGGTTTCTATTTTGCACACGGGCAGGAGGAC; CTTTTGCATTCTCTTCAGACACAATTTGTGGAGACCCCGGCGGGCCCGGGCCTGCCGCCC; CCCAGCCCTGTCGCACCAAGCTGGCCCTCCTTCCTCCCTCAGGGGAGGTGGGCCATGCAG; CTAACCCACCCACCAAAGACCCCCTCACCCTGGCCCCTTGGGCTGGACCCTCCAATGCCA; GCGACTCCCAGGAGCCCTTGGGGGACGTGAGGGGAGCCTCTCACATCCGATTTCTCCTCC; TGCCCCAGCCTCCTGTCTATCCCAGGGTCTCTGTTGCCACCATCAGATTATAAGCTCCTG; ATGCTGGGGGGGCCCAGCCATCCCCCTCCCCCCAGCACCCACAATTTTCAGTCCCCTCCC; CTCTGCCCTGTTTTGTATACCCCTCCCCTGACCCTGCTCCTATCCCACAGTATTTAATGC; CCTGTCAGTCCCTTCTAGTCTGACTCAATGGTAACTTGCTGTATTTGAATTTTTTATAGA; TGTATATACAGGGTGGGGGGAGTGGGCGGTTCTCATTAAACGTCACCATTTCATGAAAAA; AAAAAAAAAAAAACTCGAC;
  5' Read Nucleotide Sequence

  >OriGene 5' read for NM_147164 unedited; GTTGCACCAATAGTATACGACTCACTATAGGCGGCCGCGAATTCGCACGAGGGCGGCGGC; AGCGGAGGCGGCGGCTCCAGCCGGCGCGGCGCGAGGCTCGGCGGTGGGATCCGGCGGGCG; GTGCTAGCTCCGCGCTCCCTGCCTCGCTCGCTGCCGGGGGCGGTCGGAAGGCGCGGCGCG; AAGCCCGGGTGGCCCGAGGGCGCGACTCTAGCCTTGTCACCTCATCTTGCCCCCTTGGTT; TTGGAAGTCCTGAAGAGTTGGTCTGGAGGAGGAGGAGGACATTGATGTGCTTGGTGTGTG; GCCAGTGGTGAAGAGATGGCTGCTCCTGTCCCGTGGGCCTGCTGTGCTGTGCTTGCCGCC; GCCGCCGCAGTTGTCTACGCCCAGAGACACAGTCCACAGGAGGCACCCCATGTGCAGTAC; GAGCGCCTGGGCTCTGACGTGACACTGCCATGTGGGACAGCAAACTGGGATGCTGCGGCG; ACGTGGCGGGTAAATGGGACAGACCTGGCCCCTGACCTGCTCAACGGCTCTCAGCTGGTG; CTCCATGGCCTGGAACTGGGCCACAGTGGCCTCTACGCCTGCTTCCACCGTGACTCCTGG; CACCTGCGCCACCAAGTCCTGCTGCATGTGGGCTTGCCGCCGCGGGAGCCTGTGCTCAGC; TGCCGCTCCACACTTACCCCAAGGGCTTCTACTGCAGCTGGCATCTGCCCACCCCACCTA; CATTCCCAACACCTTCAATGTGACTGTGCTGCATGGCTCCAAAATATGGCCCGTGAGGAA; GACCCANCCTCAATAACCGTTGCACATTCCCTACATGCACCTGTTCTCCACCATCAATTA; CAAAGTCTCCATAAGTGTCCAGCATGCCCTGGGCCACATGCCCCAGTTTCACCTTTGACG; AGTTCCCATTGTGAACCT;
  3' Read Nucleotide Sequence

  >OriGene 3' read for NM_147164 unedited; TTAGCTTGGCCGCGGCCGCATCTANAGTCGGTTTTTTTTTTTTTTTTTTCATGAAATGGT; GACGTTTAATGAGAACCGCCCACTCCCCCCACCCTGTATATACATCTATAAAAAATTCAA; ATACAGCAAGTTACCATTGAGTCAGACTAGAAGGGACTGACAGGGCATTAAATACTGTGG; GATAGGAGCAGGGTCAGGGGAGGGGTATACAAAACAGGGCAGAGGGGAGGGGACTGAAAA; TTGTGGGTGCTGGGGGGAGGGGGATGGCTGNNCCCCCCCANCNTCACGAGCTTATAATCT; GATGGTGGCAACAGAGACCCTGGGATAGACAGGAGGCTGGGGCAGGAGGAGAAATCGGAT; GTGAGAGGCTCCCCTCACGTCCCCCAAGGGCTCCTGGGAGTCGCTGGCATTGGAGGGTCC; AGCCCAAGGGGCCAGGGTGAGGGGGCCTTTGGTGGGTGGGCCCCTTGCCTGGCCCACCTC; CCCTGACGCAGGCAAGATGCCCCACCCGCCGCCATTGACCCCGCCGGCGCGCCGCACCCG; TCCCCTCTCCTTCCTTCCCTTCCCCCCTTCCCCCTGTCTCGCGGCCCCCTCTGACCGCGC; GTCTCCCCTCCCGTCTCCCCCCCCTCCCCGCCCCCCTCTCGCCCCTGTCTGCGTCGCCGC; CGTTTTTCTCTACCCTCCTCTCTCTTCTTCATCAGCCCCCCCCCTCCCCGCTCCTTCCTT; CTTCTCACTCCCCCCCCACACAAAGTACCAACGCTCCCGCGGTTTTATCATATTTTTTCC; CATCCTCCCCCTCCCCCGCCCCCCTCCGAATCCTTGCCCCGCCCCGTCCCCCCCCCCCCC; ACCCCTTCTCCCTTCCCCGCCTTCTCTTTTTCCTCTATCTCTGACTCTCGCCCCCCTTTC; TGCGCTTCCCCCTTCCCCTCTCTCTCT;
• Restriction Sites: NotI-NotI
• ACCN: NM_147164
• Insert Size: 2170 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution Method: 1. Centrifuge at 5,000xg for 5min.; 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.; 3. Close the tube and incubate for 10 minutes at room temperature.; 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.; 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.
• Note: Plasmids are not sterile. For experiments where strict sterility is required, filtration with 0.22um filter is required.
• Shipping: Ambient

Reference Data

• RefSeq: NM_147164.1, NP_671693.1
• RefSeq Size: 2055 bp
• RefSeq ORF: 1119 bp
• Locus ID: 1271
• UniProt ID: P26992
• Cytogenetics: 9p13.3
• Domains: FN3, ig, IG, IGc2
• Protein Families: Druggable Genome
• Protein Pathways: Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway
• Summary: This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]; Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.