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Son (NM_178880) Mouse Untagged Clone
CAT#: MC225318
Son (untagged) - Mouse Son DNA binding protein (Son), transcript variant 1, (10ug)
"NM_178880" in other vectors (2)
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Specifications
| Product Data | |
| Type | Mouse Untagged Clone |
| Tag | Tag Free |
| Symbol | Son |
| Synonyms | 2900011L12Rik; AA409051; AU067731; C81487; mKIAA1019; nrebp |
| Vector | pCMV6-Entry |
| E. coli Selection | Kanamycin (25 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>MC225318 representing NM_178880
Red=Cloning site Blue=ORF Orange=Stop codon TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC GCCGCGATCGCC ATGGCGGCCGACATCGAGCAGGTTTTCAGGTCTTTCGTGGTCAGTAAATTCCGGGAAATACAACAGGAGC TTTCCAGTGGAAGGAGTGAAGGCCAGCTGAATGGTGAAACAAATCCACCCATTGAAGGGAACCAGGCAGG TGACACAGCTGCCTCTGCAAGGAGTCTCCCAAATGAAGAAATAGTGCAGAAGATAGAGGAGGTCCTCTCT GGGGTCTTAGATACGGAGCTGCGGTACAAGCCCGACTTGAAAGAGGCCTCCAGAAAAAGTAGATGCGTAT CTGTGCAAACAGATCCTACTGATGAAGTGCCCACCAAAAAGTCAAAGAAGCATAAAAAGCACAAAAACAA AAAGAAGAAAAAGAAGAAAGAAAAAGAAAAAAAATATAAAAGACAACCAGAAGAATCTGAGTCCAAGCTG AAATCTCATCATGATGGGAATCTAGAATCTGATTCCTTCTTAAAGTTTGATTCTGAACCTTCAGCAGCGG CACTGGAACATCCTGTAAGAGCGTTTGGCTTATCTGAGGCCAGTGAGACCGCCTTAGTGCTGGAACCTCC AGTAGTCTCAATGGAGGTTCAGGAGTCACACGTTCTAGAGACTCTGAAGCCAGCTACAAAAGCTGCAGAA CTGTCAGTTGTGTCTACATCAGTAATCTCAGAGCAGTCTGAGCAGCCTATGCCAGGTATGCTGGAACCAT CAATGACAAAGATCCTGGATTCCTTCACAGCAGCACCAGTGCCTATGTCAACAGCGGCGCTGAAGTCACC TGAGCCCGTTGTAACAATGTCAGTGGAATATCAGAAGTCTGTGCTGAAATCTTTGGAGACTATGCCTCCA GAGACGTCAAAGACCACGCTGGTAGAGCTTCCCATAGCAAAAGTGGTTGAGCCATCAGAAACCCTCACGA TAGTGTCAGAGACACCTACTGAGGTGCACCCTGAACCAAGCCCATCAACAATGGATTTTCCAGAGTCATC TACAACTGACGTGCAAAGATTGCCAGAGCAGCCTGTAGAAGCACCATCGGAGATTGCAGATTCATCCATG ACAAGACCTCAGGAGTCACTGGAGCTGCCTAAGACCACAGCGGTGGAGCTGCAGGAGTCGACGGTGGCCT CAGCTCTGGAGTTGCCGGGGCCACCTGCGACCTCCATTCTGGAGTTGCAGGGGCCCCCTGTGACTCCAGT GCCAGAGTTGCCTGGGCCCTCTGCCACCCCAGTGCCAGAGTTGTCAGGGCCCCTTTCTACCCCAGTGCCT GAGTTGCCAGGGCCCCCTGCGACAGTGGTCCCTGAGTTGCCGGGGCCCTCTGTGACACCAGTGCCACAGT TGTCGCAGGAATTGCCAGGGCCTCCAGCACCATCCATGGGGTTGGAGCCACCACAGGAGGTACCAGAGCC ACCTGTGATGGCACAGGAGTTATCAGGGGTGCCTGCAGTGTCGGCAGCGATAGAGTTGACAGGGCAACCT GCAGTAACAGTAGCAATGGAGTTGACCGAACAACCTGTGACGACGACAGAGTTCGAGCAGCCTGTGGCGA TGACAACGGTGGAGCATCCTGGGCATCCTGAGGTGACAACAGCTACAGGGTTGCTGGGGCAGCCAGAGGC AGCAATGGTGCTGGAGTTGCCAGGCCAGCCAGTGGCAACCACAGCGCTGGAGTTGTCTGGGCAGCCTTCG GTGACTGGGGTGCCAGAGTTGTCAGGGCTGCCTTCGGCAACTAGGGCACTGGAGTTGTCAGGGCAGTCTG TGGCAACTGGGGCATTAGAGTTGCCTGGTCAGCTCATGGCAACTGGGGCACTGGAGTTTTCGGGGCAGTC TGGGGCAGCTGGAGCACTGGAGCTTTTGGGGCAGCCCCTAGCAACGGGGGTGCTAGAGTTACCAGGGCAG CCTGGAGCGCCAGAGTTGCCTGGGCAGCCTGTGGCAACTGTGGCGCTGGAGATCTCTGTTCAGTCTGTGG TGACAACATCGGAGCTGTCAACGATGACCGTGTCGCAGTCCCTGGAGGTGCCCTCGACGACAGCGCTGGA ATCCTATAATACGGTAGCACAGGAGCTGCCTACTACATTGGTGGGGGAGACTTCTGTAACAGTAGGAGTG GACCCCTTGATGGCCCAAGAATCCCATATGCTAGCTTCTAACACCATGGAGACCCATATGTTAGCATCCA ATACCATGGACTCCCAGATGCTAGCATCCAACACTATGGATTCTCAGATGCTAGCATCCAATACCATGGA CTCCCAGATGTTAGCCTCTAGCACCATGGACTCCCAGATGTTAGCCTCTAGCACCATGGACTCCCAGATG TTAGCAACTAGCACCATGGACTCCCAGATGTTAGCAACTAGCTCTATGGACTCCCAGATGTTAGCAACTA GCTCTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGCAGTATGGA CTCCCAGATGTTAGCAACCAGCTCCATGGACTCCCAGATGTTAGCAACCAGCAGTATGGACTCCCAGATG TTAGCAACCAGCAGTATGGACTCCCAGATGTTAGCAACCAGTTCCATGGACTCCCAGATGTTAGCATCTG GTGCTATGGATTCTCAGATGTTAGCTTCTGGCACTATGGATGCTCAGATGTTAGCATCTGGTACTATGGA TGCCCAAATGTTAGCATCTAGTACCCAGGATTCTGCTATGATGGGTTCAAAGTCTCCTGATCCCTATAGG TTAGCTCAGGATCCTTACAGATTAGCTCAGGATCCCTATAGGTTGGGTCATGACCCCTACAGGTTAGGCC ATGATGCTTACAGGTTAGGACAAGACCCTTATAGATTAGGCCATGATCCCTACAGACTAACTCCGGATCC CTATAGGGTATCACCTAGGCCCTATAGAATAGCACCCAGGTCCTATAGGATAGCACCTAGGCCATACAGG TTAGCACCTAGACCCTTGATGTTAGCATCTAGACGTTCTATGATGATGTCCTATGCTGCAGAACGTTCCA TGATGTCATCTTATGAGCGCTCTATGATGTCTTATGAACGCTCTATGATGTCCCCTATGGCTGAACGCTC TATGATGTCGGCCTATGAGCGCTCCATGATGTCAGCTTATGAGCGCTCCATGATGTCTCCTATGGCTGAG CGTTCTATGATGTCAGCTTATGAGCGCTCTATGATGTCAGCTTATGAGCGCTCCATGATGTCTCCTATGG CTGATCGATCCATGATGTCCATGGGTGCCGACCGGTCTATGATGTCATCGTACTCTGCAGCTGACCGGTC TATGATGTCATCGTACTCTGCAGCTGATCGATCAATGATGTCATCTTACACTGATCGATCAATGATGTCT ATGGCAGCTGATTCTTACACTGATTCTTATACTGATTCCTATACGGAGGCATATATGGTGCCACCTTTGC CTCCTGAAGAGCCCCCAACAATGCCACCATTGCCACCCGAGGAACCACCAATGACACCCCCATTACCTCC TGAGGAACCACCAGAGGGTCCAGCATTATCAACAGAGCAGTCAGCATTAACAGCTGACAATACTTGGTCT ACAGAGGTGACATTATCTACTGGAGAATCTCTATCACAGCCTGAGCCTCCTGTGAGTCAAAGTGAGATTT CAGAGCCTATGGCAGTACCTGCTAATTATTCAATGTCAGAATCAGAAACTTCAATGTTAGCATCAGAGGC TGTTATGACTGTTCCAGAACCTGCACGAGAGCCCGAGTCTTCAGTTACATCAGCACCAGTTGAGTCTGCT GTAGTAGCAGAACATGAAATGGTTCCAGAGAGACCGATGACTTACATGGTTTCTGAGACTACCATGTCAG TCGAGCCAGCTGTGTTAACATCAGAGGCTTCTGTTATATCAGAGACATCAGAAACATATGATTCCATGAG ACCTTCAGGACATGCTATCTCAGAGGTAACTATGTCACTCTTGGAGCCAGCAGTAACTATTTCACAGCCA GCAGAGAACAGTCTAGAGCTCCCATCCATGACTGTCCCAGCACCTTCTACTATGACTACCACAGAATCTC CAGTTGTTGCTGTCACAGAAATTCCTCCTGTGGCTGTCCCAGAACCTCCCATTATGGCTGTTCCAGAACT CCCCACCATGGCTGTAGTAAAAACCCCCGCTGTGGCTGTCCCAGAACCTCTTGTGGCTGCTCCAGAGCCT CCTACCATGGCTACTCCAGAACTTTGCTCCTTATCTGTCTCAGAACCTCCTGTGGCTGTCTCGGAGCTTC CAGCTTTGGCTGACCCAGAGCATGCTATCACTGCAGTGTCAGGTGTTTCTTCCCTGGAGCCTTCTGTGCC TATTTTGGAACCAGCAGTATCAGTCCTTCAACCTGTTATGATTGTTTCAGAACCGTCTGTTCCTGTCCAG GAACCTACCGTGGCAGTGTCAGAACCTGCTGTCATAGTCTCAGAGCACACGCAAATAACATCACCTGAGA TGGCTGTAGAGTCTTCACCAGTAATAGTGGACTCTAGTGTTATGTCATCACAGATTATGAAAGGAATGAA TTTGCTTGGTGGTGATGAAAATCTTGGTCCAGAGGTTGGCATGCAGGAGACTCTGTTGCATCCAGGTGAA GAGCCACGTGATGGAGGACACTTGAAAAGTGACTTGTATGAAAATGAGTATGATAGAAATGCAGACCTTA CTGTAAACAGTCATTTAATTGTTAAAGATGCAGAGCATAACACAGTGTGTGCTACTACCGTTGGTCCTGT TGGTGAAGCAAGTGAAGAGAAAATTTTGCCTATTAGTGAGACTAAGGAAATCACAGAATTGGCTACCTGT GCTGCCGTCAGCGAAGCTGACATAGGCAGAAGTCTGTCTTCTCAGCTTGCTCTGGAGCTGGATACAGTAG GAACTAGTAAGGGGTTTGAATTTGTCACTGCATCTGCACTCATTTCAGAGAGTAAATATGATGTTGAAGT ATCTGTAACTACTCAAGATACTGAACATGACATGGTAATTTCCACCAGCCCCAGTGGTGGCAGCGAAGCA GACATAGAGGGACCTTTGCCTGCTAAAGACATTCATCTTGATTTGCCATCAACTAATTTTGTTTGTAAGG ATGTAGAAGACTCGTTACCTATCAAAGAGAGTGCCCAGGCAGTGGCAGTGGCTCTTAGCCCTAAAGAGAG CAGTGAAGATACAGAAGTACCTCTTCCCAATAAAGAAATAGTTCCTGAGTCAGGATATTCTGCCAGCATT GATGAAATTAATGAAGCTGACTTAGTGAGACCATTACTTCCTAAGGACATGGAGCGTCTTACAAGCCTTA GAGCTGGCATTGAAGGACCTTTACTTGCTAGTGAGGTTGAACGTGACAAGTCAGCTGCCAGTCCAGTTGT AATTAGCATACCAGAAAGAGCTTCAGAGTCATCTTCAGAGGAAAAGGATGATTATGAAATTTTTGTCAAA GTTAAGGACACACATGAAAAAAGCAAGAAAAACAAAAACCGTGACAAAGGTGAGAAGGAGAAGAAAAGGG ACTCTTCATTACGGTCTCGGAGTAAGCGTTCCAAGTCTTCTGAACATAAGTCACGCAAGCGCACCAGTGA GTCGCGTTCTAGAGCAAGGAAGAGGTCGTCCAAGTCCAAATCTCACCGTTCTCAGACACGGTCACGGTCA CGCTCAAGACGCAGGAGGAGGAGTAGCCGATCAAGATCTAAGTCTAGAGGAAGACGGTCTGTATCAAAAG AGAAACGCAAAAGGTCTCCAAAGCATAGATCCAAGTCCAGGGAAAGGAAAAGGAAAAGATCAAGCTCACG AGACAACCGGAAAGCAGCTCGAGCTCGGAGTCGAACCCCGAGTCGGCGGAGTAGGAGCCACACTCCTAGT CGGAGGAGACGGTCTAGATCTGTTGGTAGAAGGAGAAGTTTTAGCATTTCCCCCAGCCGCAGGAGCCGAA CCCCCAGCCGCAGGAGCAGAACCCCCAGCCGCAGGAGCCGAACCCCCAGCCGCAGGAGCCGAACCCCCAG CCGCAGGAGCCGAACCCCCAGCCGTCGGAGAAGATCACGGTCTGCGGTAAGAAGACGAAGCTTCAGTATA TCACCGGTCAGATTAAGGCGATCAAGAACACCTTTGAGAAGAAGGTTTAGTAGATCTCCCATTCGGCGGA AAAGATCCAGGTCTTCAGAAAGAGGCAGATCGCCCAAACGTCTAACAGATTTGGATAAGGCTCAATTACT TGAAATAGCCAAAGCTAATGCAGCTGCCATGTGTGCTAAGGCTGGTGTTCCTTTACCACCAAACCTAAAG CCTGCACCTCCACCTACAATAGAAGAGAAAGTTGCTAAAAAGTCTGGAGGAGCTACCATAGAAGAACTAA CTGAGAAATGCAAACAGATTGCACAGAGTAAAGAAGATGATGATGTAATAGTGAATAAACCTCATGTTTC GGATGAAGAGGAAGAAGAACCTCCTTTTTATCATCATCCCTTTAAACTCAGTGAACCCAAGCCCATTTTT TTCAATTTGAATATTGCTGCAGCAAAGCCAACTCCACCGAAAAGCCAAGTAACATTAACAAAGGAGTTTC CTGTGTCATCCGGATCTCAACATCGGAAAAAGGAAGCGGATAGTGTTTATGGAGAGTGGGTTCCAGTCGA GAAAAATGGTGAAGAAAGCAAAGATGATGATAATGTTTTCAGCAGCAGCTTGCCCTCAGAGCCTGTGGAC ATTTCAACAGCAATGAGTGAACGGGCACTTGCTCAGAAGAGGCTCAGTGAGAATGCATTTGACCTTGAAG CCATGAGTATGTTAAACCGAGCTCAAGAACGGATTGACGCCTGGGCTCAGTTGAATTCTATCCCTGGGCA GTTCACAGGGAGCACAGGAGTGCAGGTCCTGACACAGGAGCAGCTGGCTAATACTGGGGCCCAAGCCTGG ATTAAAAAGGATCAGTTCTTAAGAGCAGCCCCAGTGACTGGAGGAATGGGAGCTGTTTTGATGAGAAAAA TGGGCTGGAGAGAAGGAGAAGGATTAGGAAAGAACAAAGAAGGAAATAAGGAACCCATCCTTGTTGATTT TAAGACAGACCGAAAAGGTCTTGTTGCAGTAGGAGAGAGAGCACAAAAGCGTTCTGGGAACTTCTCTGCT GCAATGAAAGACTTATCAGGCAAACATCCTGTGTCTGCCTTGATGGAAATCTGTAATAAGAGAAGGTGGC AACCACCTGAATTTCTCTTGGTCCATGACAGTGGCCCTGACCATCGCAAACATTTCCTCTTTAGGGTATT GAGAAATGGAAGCCCTTACCAGCCCAATTGTATGTTTTTCTTGAATAGGTATTGA ACGCGTACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGATT ACAAGGATGACGACGATAAGGTTTAA |
| Restriction Sites | SgfI-MluI |
| ACCN | NM_178880 |
| Insert Size | 7335 bp |
| OTI Disclaimer | Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery. The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_178880.4, NP_849211.3 |
| RefSeq Size | 8451 bp |
| RefSeq ORF | 7335 bp |
| Locus ID | 20658 |
| UniProt ID | Q9QX47 |
| Cytogenetics | 16 53.22 cM |
| Gene Summary | RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3' (By similarity). Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (By similarity). May also regulate the ghrelin signaling in hypothalamic neuron by acting as a negative regulator of GHSR expression (PubMed:20876580).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). |
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