Srcin1 (NM_018873) Mouse Untagged Clone

CAT#: MC223972

Srcin1 (untagged) - Mouse SRC kinase signaling inhibitor 1 (Srcin1), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Srcin1
• Synonyms: mKIAA1684; P140; p140Cap; SNIP
• Vector: pCMV6-Entry
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >MC223972 representing NM_018873
  Red=Cloning site Blue=ORF Orange=Stop codon
  
  TTTTGTAATACGACTCACTATAGGGCGGCCGGGAATTCGTCGACTGGATCCGGTACCGAGGAGATCTGCC
  GCCGCGATCGCC
  
  ATGGGGAACGCTCCGTCCCAAGATCCGGAGCGGAGCAGCCCCCCCATGCTGTCTGCAGACGATGCCGAGT
  ACCCTCGGGAGTACCGGACCCTGGGGGGTGGGGGCGGAGGTGGCAGCGGGGGCCGGCGCTTCTCCAACGT
  GGGGCTGGTGCACACCTCGGAGCGCCGGCACACGGTGATCGCTGCCCAGAGCCTGGAGGCCCTCAGCGGG
  CTCCAGAAAGCGGATGCTGACCGCAAGCGAGATGCGTTCATGGACCACCTGAAGAGCAAGTACCCTCAGC
  ACGCCCTGGCCCTGCGAGGTCAGCAGGACAGGATGCGAGAACAGGTCGGCGGCTGGACCGTGGACCCTGT
  GTGCCTCCTCAGCTCCCTCTGTTCCCACCTCCACGGCGACTCCACCCCCTCAGGGGCTGGCCAGCCTGCC
  CAGCAACCAAACTACTGGAGTTTCAAGACCCGCAGCTCGCGCCATACTCAGGGAGCCCAGCCAGGGCTAG
  CAGACCAGGCAGCCAAGCTGTCCTACGCCTCGGCTGAGTCGCTGGAGACAATGTCCGAGGCCGAGCTGCC
  CCTGGGCTTCAGCAGGATGAACCGCTTCCGACAGAGCTTGCCTCTCTCCCGCTCTGCCAGCCAGACCAAG
  CTGCGCTCACCAGGGGTCCTGTTCCTGCAGTTTGGAGAGGAGACACGACGTGTACACATCACGCATGAGG
  TCAGCAGCTTGGACACGCTGCACGCACTCATCGCGCACATGTTCCCTCAGAAGCTCACCATGGGCATGCT
  TAAGTCGCCCAACACCGCCATCCTCATCAAGGACGAGGCTCGCAATGTCTTCTACGAGCTGGAAGACGTC
  CGGGATATCCAAGACCGAAGTATCATTAAGATCTATAGGAAGGAGCCGTTGTATGCTGCTTTTCCTGGCT
  CACACCTCACCAACGGTGACCTCCGGAGAGAAATGGTTTACGCGTCGCGGGAGTCGTCGCCCACGCGGCG
  CCTCAACAACCTGTCGCCCGCATCGCACCTAGCATCTAGCTCCCCGCCTCCAGGGCTGCCATCGGGGCTG
  CCTTCGGGACTGCCATCGGGCTCGCCTTCGCGTTCACGCCTCTCCTATGCTGGGGGCCGGCCGCCCTCTT
  ACGCCGGCAGCCCGGTGCACCACGCGGCTGAGCGACTGGGAGGCGCCCCGACCGGCCAGGGCGTGAGCCC
  CAGCCCCAGCGCCATCCTGGAGCGGCGCGACGTGAAGCCAGATGAGGACCTGGCGGGCAAGGCTGGCGGC
  ATGGTGCTGGTGAAGGGCGAGGGCCTCTATGCCGATCCCTACGGGCTGCTGCACGAGGGCCGTCTGAGCC
  TGGCCGCCGCGGCGGGAGACCCATTCGCATACCCGGGCGCGGGCGGCTTGTACAAGCGGGGTTCCGTGCG
  CTCTCTCAGCACCTACTCCGCTGCCGCGCTGCAGTCCGACCTGGAGGACTCGCTGTACAAGGCGGGCGCT
  GGCGGCCCGCTCTACGGAGACGGCTATGGCTTCCGTCTGCCGCCCTCGTCCCCGCAGAAGCTGGCCGACG
  TCTCGGCGCCCTCCGGGGGACCTCCACCCCCGCACAGCCCCTACTCCGGGCCACCCAGCCGCGGCTCGCC
  GGTGCGCCAGTCCTTCCGCAAAGATTCGGGCTCCTCGTCGGTCTTTGCTGAGAGTCCTGGAGGCAAGGCC
  CGCAGCACCGGGAGTGCCTCCACGGCCGGAGCACCACCTTCTGAACTCTTCCCTGGACCTGGGGAGCGCT
  CCCTTGTAGGGTTCGGGCCGCCGGTGCCAGCCAAAGACACAGAGACCAGGGAACGCATGGAGGCTATGGA
  GAAGCAGATTGCCAGCCTCACTGGCCTAGTACAGAGTGCCCTACTGCGAGGCTCAGAGCCGGAGACCCCA
  AGTGAGAAGGTTGAAGGCTCCAATGGAGCAGCCACTCCCTCAGCACCAGTGTGTGGGTCAGGCAGTAAGA
  GTAGCGGGGCCACTCCGGTGTCGGGCCCTCCCCCGCCCTCGGCCAGCAGCACCCCTGCAGGGCAGCCCAC
  TGCTGTCAGCCGTCTGCAGATGCAGCTGCATCTGCGTGGCCTACAGAACAGCGCTAGCGACCTGCGTGGC
  CAGCTTCAGCAGCTGCGCAAGCTCCAGCTCCAGAACCAGGAGTCGGTGCGCGCGCTGCTGAAGCGCACCG
  AGGCGGAGCTGAGCATGCGCGTGTCGGAGGCGGCGCGGCGGCAGGAGGACCCGCTGCAGCGGCAGCGCAC
  CCTGGTGGAGGAGGAGCGTTTGCGTTACCTCAACGACGAGGAGCTCATTACTCAGCAGCTCAATGACCTC
  GAGAAGTCAGTGGAGAAGATCCAGAGAGACGTGGCCCATAACCACCGGCTAGTGCCGGGTCCTGAGTTGG
  AAGAGAAGGCGCTGGTGCTGAAGCAGCTTGGGGAGACGCTGACGGAGCTCAAGGCTCATTTCCCAGGCCT
  GCAGAGTAAGATGCGGGTGGTGCTGCGCGTGGAGGTGGAGGCAGTGAAGTTCCTGAAGGAGGAACCTCAA
  CGCCTTGACGGGCTCCTCAAGCGCTGCCGGGGGGTCACTGACACGCTGGCCCAGATCCGAAGGCAAGTGG
  ATGAGGGTATGTGGCCCCCCCCCAACAACCTCCTGAACCAGTCCCCCAAGAAGGTGGCAGCTGAAACCGA
  CTTCAGCAAAGGCTTGGATTTTGAAATACCACCCCCGAGTCCTCCACTGAATCTTCACGAGCTGAGTGGA
  CCTGCCGAAGGCACCCCTCTCACCCCAAAGAGCACTAACCCCACCAAAGGCCTGGATGCTTCCAGCAAGA
  GAAACACGGACAAAGCTGTGTCTGTTGAGGCTGCGGAGAGAGACTGGGAAGAGAAGCGGGCAGCCCTGAC
  CCAGTACAGCGCCAAGGACATCAACCGGCTGCTGGAAGAGACCCAGGCTGAGCTGCTCAAGGCTATCCCT
  GACCTGGACTGTGCCAGCAAGACCCACCCAGGCCCTGCTCCCACTCCAGACCACAAGCCCCCTAAGGCAC
  CCCATGGTCAGAAGGCAGCTCCCCGGACAGAGCCCAGTGGGAGAAGAGGATCAGATGAGCTCACAGTGCC
  CCGATACCGCACAGAGAAGCCCTCCAAGTCACCCCCGCCACCCCCTCCCCGCCGGAGCTTCCCTTCCTCC
  CATGGCCTGACCACAACACGCACTGGAGAAGTGGTGGTCACCAGTAAGAAAGACTCAGTCTTCATCAAGA
  AGGCTGAGTCCGAGGAGCTAGAGGTCCAGAAGCCCCAGGTGAAGCTGCGCCGTGCTGTGTCTGAGGTGGT
  CCGCCCCGCATCCACGCCGCCCATTATGGCCTCTGCCATCAAGGACGAGGACGACGAGGAGAGGATCATT
  GCTGAGCTGGAGAGTGGTGGTAGCAGCGTGCCACCCATGAAGGTGGTGACTCCCGGAGCCTCGAGGCTGA
  AGGCGGCCCAGGGCCCAGCAGGCAGCCCTGATAAAGGCAAACATGGCAAGCAACGAACGGAATACATGAG
  GATCCAGGCCCAGCAGCAGGCCACTAAACCATCTAAAGAGGTGAGCGGTCCGAATGAGACCTCAAGCCCC
  GGCTCAGAAAAGCCCTCTGGTTCCAGAACCTCCATCCCTGTATTGACTTCCTTTGGGGCAAGGAATTCTT
  CCATCTCCTTCTAG
  
  ACGCGGCCGCTCGAGCAGAAACTCATCTCAGAAGAGGATCTGGCAGCAAATGATATCCTGGA
  TTACAAGGATGACGACGATAAGGTTTAA
• Restriction Sites: SgfI-NotI
• ACCN: NM_018873
• Insert Size: 3654 bp
• OTI Disclaimer: Due to the inherent nature of this plasmid, standard methods to replicate additional amounts of DNA in E. coli are highly likely to result in mutations and/or rearrangements. Therefore, OriGene does not guarantee the capability to replicate this plasmid DNA. Additional amounts of DNA can be purchased from OriGene with batch-specific, full-sequence verification at a reduced cost. Please contact our customer care team at custsupport@origene.com or by calling 301.340.3188 option 3 for pricing and delivery.
  
  The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: NM_018873.2, NP_061361.2
• RefSeq Size: 6965 bp
• RefSeq ORF: 3654 bp
• Locus ID: 56013
• UniProt ID: Q9QWI6
• Cytogenetics: 11 D
• Gene Summary: Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance (By similarity).[UniProtKB/Swiss-Prot Function]