Crtc2 (NM_028881) Mouse Untagged Clone

CAT#: MC204255

Crtc2 (untagged) - Mouse CREB regulated transcription coactivator 2 (Crtc2), (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Crtc2
• Synonyms: 4632407F12Rik; mTORC2; Torc2
• Vector: PCMV6-Kan/Neo
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >BC023831
  CCACGCGTCCGCTCGCGGAGGCGGCGGCGGCTGCTGCTAAGGCTGAAGGAGCCGGGCCGGGCCCGCGGCA GAGGCCGTGGCTGGAACTGGGAAGGTGGCGGGGACGGACGCGGGGGTAAGATGGCGACGTCAGGGGCGAA CGGGCCGGGTTCCGCCACAGCCTCAGCGTCCAATCCACGCAAGTTTAGTGAGAAGATTGCGCTGCAGAAG CAGCGTCAGGCCGAGGAGACGGCGGCCTTCGAGGAGGTGATGATGGACATCGGCTCCACACGGTTACAGG CCCAAAAACTGCGACTGGCTTATACAAGGAGCTCCCATTATGGTGGTTCTCTGCCCAATGTTAACCAGAT TGGCTGTGGCCTGGCTGAGTTCCAGAGCCCCCTTCACTCACCTTTGGATTCATCTCGGAGCACTCGGCAC CATGGGTTGGTGGAACGGGTACAACGAGATGCCCGCAGAATGGTGTCCCCACTCCGCCGATACCCCCGCC ACATTGACAGTTCTCCATATAGCCCTGCCTATTTATCTCCTCCCCCAGAGTCTGGCTGGCGAAGGATGAT GCCCTGGGGCAACCTCCCAGCTGAGAAGGGGCAGTTGTTTAGACTGCCGTCTGCACTTAACAGGACAAGC TCTGACTCTGCTCTTCACACAAGTGTGATGAACCCTAACCCCCAAGACACTTATCCAGGCCCCACACCTC CCAGTGTCCTGCCCAGCCGCCGAGGAGGAGGTTTTCTGGATGGTGAGATGGATGCTAAAGTCCCTGCTAT TGAGGAGAACGTGGTAGATGACAAGCATCTGCTGAAACCTTGGGATGCTAAGAAGCTGTCCTCATCTTCC TCTCGACCTCGATCCTGTGAAGTCCCTGGAATCAACATCTTTCCATCTCCTGACCAGCCTGCTAATGTGC CTGTCCTCCCACCTGCCATGAACACAGGAGGCTCCCTACCTGACCTCACCAACCTACACTTCCCTCCTCC ACTGCCCACACCCCTGGACCCTGAGGAGACAGTCTATCCCAGCCTGAGTGGGGGCAACAGTACCACCAAT TTGACCCATACTATGACCCATTTGGGCATCAGTGGAGGTCTGGGCTTGGGCCCCAGCTATGATGTACCAG GACTTCACTCACCTCTTAGCCACCCATCCCTGCAGTCCTCCCTAAGCAATCCCAACCTCCAGGCTTCCCT AAGTAGTCCTCAACCCCAGCTCCAGGGCTCCCATAGTCACCCATCACTGCCTGCCTCCTCCTTGGCCCAC CATGCACTGCCCACCACCTCCCTGGGCCACCCGTCACTTAGTGCCCCAGCCCTTTCCTCCTCCTCTTCCT CTTCGTCCACTTCATCTCCTGTCCTGAGTGCTCCCCCTTACCCAGCTTCTACTCCTGGGGCCTCTCCCCG CCACCGTCGTGTGCCCCTCAGCCCCCTGAGCTTGCCCGCGGGCCCAGCCGACGCCAGAAGGTCCCAACAG CAGCTGCCCAAACAGTTTTCGCCAACAATGTCACCCACCTTGTCTTCCATCACTCAGGGCGTTCCCTTGG ATACCAGTAAATTGCCTACTGACCAGCGATTGCCCCCATACCCATATAGCCCCCCAAGTCTAGTTATACC CACCCATCCACCCACCCCAAAGTCTCTACAGCAGTTGCCCTCTCAGGCCTGCTTAGTGCAGCCCTCAGGT GGACAGCCTCCAGGCAGGCAGCCACATTATGGGGCACTGTACCCACCTGGGTCCAGTGGACATGGGCAAC AGCCTTACCACCGCCCAATAAATGACTTCAGCTTGGGGAATCTGGAGCAATTCAACATGGAGAGCCCATC AACCAGCCTGGTGCTGGATCCCCCTGCCTTTTCTGAAGGTCCTGGATTTTTAGGGAGTGAGGGATCAATG AGTGGCCCCCAGGACCCTCACGTCCTCAACCACCAGAACTTGACCCACTGTTCCCGCCATGGCTCAGGAC CTAATATCATACTCACAGGAGACTCTTCCCCAGGTTTCTCTAAGGAGATTGCAGCAGCCCTGGCTGGAGT GCCTGGCTTTGAGGTGTCAGCATCTGGGTTGGAGCTGGGCCTGGGGCTAGAAGATGAGCTGCGCATGGAG CCACTGGGCCTGGAAGGACTAACTATGCTGAGTGACCCCTGTGCCCTGCTGCCTGACCCTGCTGTGGAGG ACTCATTCCGTAGTGATCGGCTACAGTGAGGGGACCTCACTGCCATCCTTCTTCATGGCCCTGTCCCATC AGTCTTCATCCCTTCCCCCTGGCCAGTAGAGACTACTCTCTGCCCCCAGATCCTTTTTCTAATATGAATG AAGGATCCTAAAACTGAGGAAAGGGAAGGGGCTTGGCCAGGTGGCCCCTGAATGCTGTATGTCTGGTGGG CTTGGGGGAATTCAAGGGAGGGCCTAAAAGCACTTGTAACTTTGAAAACCGTCTGTCTGGAGGTCAGAGC CTGTTGGGAAGCAAGGTGTAGAGGGAAATCTTGGAGAGAGGGCTTGTCCAGAAGGGATGGGCACTACCAG CCCCTCCCTATTTCTCTTCCCCTTGCAATGGAAGAGAGAGCCAGAATGGATATTATTTTTTATTAAATAT ATTATATGTTAATAAAAAATCCTATTAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAA
• Restriction Sites: RsrII-NotI
• ACCN: NM_028881
• Insert Size: 2079 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: BC023831, AAH23831
• RefSeq Size: 2675 bp
• RefSeq ORF: 2079 bp
• Locus ID: 74343
• UniProt ID: Q3U182
• Cytogenetics: 3 F1
• Gene Summary: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites (PubMed:29211348). Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated (PubMed:29211348). Acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity).[UniProtKB/Swiss-Prot Function]