Bcl11b (NM_021399) Mouse Untagged Clone

CAT#: MC201286

Bcl11b (untagged) - Mouse B-cell leukemia/lymphoma 11B (Bcl11b), transcript variant 2, (10ug)

Specifications

Product Data

• Type: Mouse Untagged Clone
• Tag: Tag Free
• Symbol: Bcl11b
• Synonyms: 9130430L19Rik; AI604821; B630002E05Rik; BCL-11B; Ctip2; Rit1
• Vector: PCMV6-Kan/Neo
• E. coli Selection: Kanamycin (25 ug/mL)
• Mammalian Cell Selection: Neomycin
• Sequence Data:
  Fully Sequenced ORF

  >BC019503 sequence for NM_021399
  GCGGCTCAGACCCCCTCCCCGGCCCGCATCTGTGCAGCTTTCCGGGCGATGCCAGAATAGATGCCGGGGC AATGTCCCGCCGCAAACAGGGCAACCCGCAGCACTTGTCCCAGAGGGAACTCATCACGCCAGAGGCTGAC CATGTGGAGGCTACCATCCTCGAGGAAGACGAGGGTCTGGAGATAGAGGAGCCTAGCAGCCTGGGGCTGA TGGTGGGAGGCCCCGACCCTGATCTACTCACCTGTGGCCAGTGTCAGATGAACTTCCCGCTGGGGGACAT CCTGGTTTTTATAGAGCACAAGAAGAAACAGTGTGGAGGCCTGGGCCCCTGCTACGACAAGGTCCTGGAC AAGAGCAGTCCACCTCCCTCCTCTCGCTCTGAGCTCAGGAGAGTATCTGAGCCAGTGGAGATCGGGATCC AGGTCACCCCTGATGAAGATGACCACCTACTGTCACCCACGAAAGGCATCTGTCCCAAGCAGGAGAACAT TGCAGGTAAAGATGAGCCTTCCAGCTACATTTGCACAACATGCAAGCAGCCCTTCAACAGCGCCTGGTTC CTGCTGCAGCACGCACAGAACACGCATGGCTTCCGAATCTACCTGGAGCCTGGGCCGGCCAGCACCTCGC TCACGCCCAGGCTCACCATCCCGCCACCGCTCGGGCCGGAGACCGTGGCGCAGTCCCCACTCATGAATTT CCTGGGGGACAGCAATCCTTTCAACCTGCTGCGCATGACGGGCCCCATCCTGCGGGACCACCCTGGCTTC GGTGAGGGCCGCTTGCCAGGTACGCCACCGCTCTTCAGCCCACCGCCACGCCATCACTTGGACCCACACC GCCTCAGTGCAGAGGAGATGGGGCTCGTGGCCCAGCACCCCAGTGCCTTCGACCGAGTCATGCGCCTGAA CCCCATGGCCATAGACTCTCCTGCCATGGACTTCTCCCGGCGGCTGCGAGAACTGGCCGGCAACAGCTCC ACGCCGCCGCCCGTGTCCCCAGGCCGTGGCAACCCTATGCACCGGCTGCTGAACCCTTTCCAGCCCAGTC CCAAGTCCCCGTTCCTCAGCACGCCACCGCTGCCACCCATGCCTGCGGGCACACCGCCACCGCAGCCGCC TGCCAAGAGCAAGTCCTGTGAGTTCTGCGGCAAGACCTTCAAGTTCCAGAGCAATCTCATCGTGCACCGG CGCAGCCACACGGGCGAGAAGCCCTACAAGTGCCAGCTGTGCGACCATGCGTGCTCGCAGGCGAGCAAGC TCAAGCGCCACATGAAGACGCACATGCACAAGGCGGGCTCTCTGGCTGGCCGCTCAGACGACGGGCTCTC AGCTGCCAGCTCCCCTGAGCCGGGCACCAGCGAGCTGCCAGGTGACCTGAAAGCGGCCGATGGCGACTTC CGCCACCATGAGAGCGACCCATCTCTGGGCCCCGAGCCTGAGGACGACGAGGACGAGGAGGAGGAAGAAG AGGAGCTGCTGCTGGAGAACGAGAGCCGGCCTGAGTCGAGCTTCAGCATGGACTCGGAGCTGGGCCGTGG CCGCGAGAACGGAGGTGGTGTGCCACCGGGGGTGGCGGGCGCAGGGGCTGCAGCTGCGGCTCTGGCGGAT GAGAAGGCTCTGGCCCTGGGCAAGGTGATGGAGGACGCAGGGCTGGGCGCACTGCCGCAGTATGGGGAGA AGCGGGGCGCCTTCCTGAAGCGTGCAGGCGACACGGGTGATGCCGGAGCTGTTGGCTGTGGGGACGCGGG TGCACCGGGTGCAGTGAACGGGCGCGGCGGGGCCTTCGCGCCAGGCGCAGAGCCCTTTCCAGCTCTCTTC CCACGCAAGCCAGCACCGCTGCCCAGCCCTGGGCTCGGTGGTCCCGCGCTGCACGCGGCCAAGCGCATCA AGGTGGAGAAAGACCTGGAGCTGCCACCTGCCGCCCTCATCCCATCTGAGAACGTGTACTCGCAGTGGCT CGTGGGCTACGCAGCATCGCGCCACTTCATGAAGGACCCATTCCTGGGCTTCACGGATGCGCGCCAGTCG CCTTTCGCCACATCGTCGGAACATTCCTCTGAGAACGGCAGCCTGCGCTTCTCAACGCCACCCGGGGACC TGCTGGACGGCGGGCTGTCCGGGCGCAGTGGCACGGCGAGCGGGGGCAGCACACCTCACCTGGGTGGTCC GGGTCCTGGGAGGCCGAGCTCCAAGGAGGGCCGCCGCAGCGACACATGTGAGTACTGCGGCAAGGTCTTC AAGAACTGTAGCAACCTGACGGTGCACCGGAGGAGCCACACCGGCGAGCGGCCTTACAAGTGCGAGCTGT GCAACTACGCGTGTGCGCAGAGCAGCAAGCTCACGCGCCACATGAAGACGCACGGGCAGATCGGCAAGGA GGTGTACCGCTGCGACATCTGCCAGATGCCCTTCAGCGTCTACAGCACCCTGGAGAAACACATGAAAAAG TGGCACGGTGAACACTTGCTGACTAATGATGTCAAAATCGAGCAGGCTGAGAGGAGCTAAGCGCATACGT GGGGGACACTGCGTGCGTGCGTCTGTACAGCGTGACCATCGCCAACCTTCGCCAACGGGACCGGTGACCG GACTGGCCTCTGCATCCCCGGGGCCCAGGGAGGCGGCAGTCCAACCTAACCTGTGTCTGCGAAGTCCTAT GGAAACCTGAGGGTTGATTAAGGCAGTAAAAAATTAAAAAAAAAAAAAAA
• Restriction Sites: RsrII-NotI
• ACCN: NM_021399
• Insert Size: 2439 bp
• OTI Disclaimer: Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP).
• Product Components: The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water).
• Reconstitution: 1. Centrifuge at 5,000xg for 5min.
  2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA.
  3. Close the tube and incubate for 10 minutes at room temperature.
  4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom.
  5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C.

Reference Data

• RefSeq: BC019503, AAH19503
• RefSeq Size: 2710 bp
• RefSeq ORF: 2439 bp
• Locus ID: 58208
• UniProt ID: Q99PV8
• Cytogenetics: 12 59.1 cM
• Gene Summary: Key regulator of both differentiation and survival of T-lymphocytes during thymocyte development in mammals (PubMed:12717433). Essential in controlling the responsiveness of hematopoietic stem cells to chemotactic signals by modulating the expression of receptors CCR7 and CCR9, which direct the movement of progenitor cells from the bone marrow to the thymus (By similarity). Is a regulator of IL2 promoter and enhances IL2 expression in activated CD4(+) T-lymphocytes (PubMed:16809611). Tumor-suppressor protein involved in T-cell lymphomas. May function on the P53-signaling pathway. Repress transcription through direct, TFCOUP2-independent binding to a GC-rich response element.[UniProtKB/Swiss-Prot Function]
  Transcript Variant: This variant (2) lacks an in-frame coding exon, compared to variant 1. The resulting isoform (b) lacks an internal segment, compared to isoform a.