EMA (MUC1) Mouse Monoclonal Antibody [Clone ID: UMAB57]
$680.00
3 Days*
Specifications
| Product Data | |
| Clone Name | UMAB57 |
|---|---|
| Application | 10k-ChIP, IF, IHC, WB |
| Recommended Dilution | IHC 1:100 |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG2b |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human MUC1 (NP_001018016) produced in HEK293T cell. |
| Buffer | Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose) |
| Reconstitution Method | For reconstitution, we recommend adding 100uL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (OriGene recommends Zeba Spin Desalting Columns, 7KMWCO from Thermo Scientific) |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Ambient |
| Predicted Protein Size | 25.1 kDa |
| Gene Name | mucin 1, cell surface associated |
| Database Link | |
| Background | This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants. provided by RefSeq, Feb 2011 |
| Synonyms | ADMCKD; ADMCKD1; CA 15-3; CD227; EMA; H23AG; KL-6; MAM6; MCD; MCKD; MCKD1; MUC-1; SEC |
| Reference Data | |
| Protein Categories | ADC Targets, CAR-T Targets, CD Markers, Intracellular Proteins, Membrane Proteins, Secreated Proteins |
| Protein Families | Druggable Genome, Secreted Protein, Transmembrane |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Citations
A large-area organic transistor with 3D-printed sensing gate for noninvasive single-molecule detection of pancreatic mucinous cyst markers
Sarcina, Viola, Modena et al
Anal Bioanal Chem (2022) 414 (18), 5657-5669 DOI: 10.1007/s00216-022-04040-4
Sarcina, Viola, Modena et al
Anal Bioanal Chem (2022) 414 (18), 5657-5669 DOI: 10.1007/s00216-022-04040-4
Cited by 20
AI Summary: OriGene contributed the anti-MUC1 antibody (clone UMAB57, code: UM800008) and recombinant human MUC1 protein (product number: TP321390) used as key reagents for functionalizing the biosensor and validating single-molecule detection of pancreatic mucinous cyst markers in this study.
Snippet: UC1, clone UMAB57, code: UM800008) and the recombinant protein of human mucin 1, cell surface-associated (MUC1), transcript variant 2 (MUC1, MW = 25,100 Da, product number: TP321390) were provided by OriGene. 3-Mercaptopropionic acid (3-MPA), 11-mercaptoundecanoic acid (11-MUA), 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and the N-hydroxysulfosuccinimide sodium salt (Sulfo-NHS) were obta;cell surface-associated (MUC1), transcript variant 2 (MUC1, MW = 25,100 Da, product number: TP321390) were provided by OriGene. 3-Mercaptopropionic acid (3-MPA), 11-mercaptoundecanoic acid (11-MUA), 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDC) and the N-hydroxysulfosuccinimide sodium salt (Sulfo-NHS) were obtained from Merck Millipore
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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