beta Catenin(CTNNB1) Mouse Monoclonal Antibody [Clone ID: UMAB15]

CAT#: UM500015

Beta-Catenin (CTNNB1) mouse monoclonal antibody, clone UMAB15

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 Product Datasheet for 'UM500015'

USD 468.00


Availability*
In Stock

Size
    • 100 ul

Specifications

Product Data
Clone Name UMAB15
Applications WB, IHC, IF, FC, 10K-CHIP
Recommend Dilution WB 1:500, IHC 1:100, IF 1:100, FLOW 1:100
Reactivity Human, Mouse, Rat, Monkey
Host Mouse
Clonality Monoclonal
Immunogen Full length human recombinant protein of human CTNNB1 (NP_001895) produced in HEK293T cell.
Isotype IgG1
Formulation PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 0.5~1.0 mg/ml (Lot Dependent)
Purification Purified from mouse ascites fluids by affinity chromatography
Predicted Protein Size 85.3 kDa
Gene Name Homo sapiens catenin beta 1 (CTNNB1), transcript variant 1
Background The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
Synonyms armadillo; CTNNB; MRD19
Reference Data
Protein Families ES Cell Differentiation/IPS, Transcription Factors, Druggable Genome
Protein Pathways Wnt signaling pathway, Focal adhesion, Adherens junction, Tight junction, Leukocyte transendothelial migration, Melanogenesis, Pathogenic Escherichia coli infection, Pathways in cancer, Colorectal cancer, Endometrial cancer, Prostate cancer, Thyroid cancer, Basal cell carcinoma, Arrhythmogenic right ventricular cardiomyopathy (ARVC)
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Citations