PAX5 Rabbit Polyclonal Antibody

SKU TA899004S

PAX5 Rabbit Polyclonal Antibody

Product Data

• Application: ELISA, WB
• Recommended Dilution: ELISA 1:5000-10000, WB 1:500
• Reactivity: Human
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: This antibody is raised against a recombinant protein of PAX5 expressed in HEK293 cells
• Buffer: Tissue culture buffer containing 1% BSA and 0.02% Sodium azide
• Concentration: Lot dependent; please refer to CoA along with shipment
• Purification: Purified from the immunized serum by affinity chromatography (Protein A/G)
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: 42 kDa
• Gene Name: paired box 5
• Database Link:
  NP_057953
  Q02548
• Background: This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
• Synonyms: ALL3; BSAP

Reference Data

• Protein Families: Transcription Factors