alpha 2a Adrenergic Receptor (ADRA2A) Rabbit Polyclonal Antibody

SKU TA890050

Rabbit polyclonal anti-ADRA2A Antibody

Product Data

• Application: WB
• Recommended Dilution: WB: 1:1000
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human ADRA2A
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: 1.57mg/ml
• Purification: Purified from the immunized serum by affinity chromatography (Protein A/G)
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: 48.8 kDa
• Gene Name: adrenoceptor alpha 2A
• Database Link:
  NP_000672
  P08913
• Background: Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]
• Synonyms: ADRA2; ADRA2R; ADRAR; ALPHA2AAR; ZNF32

Reference Data

• Protein Families: Druggable Genome, GPCR, Transmembrane
• Protein Pathways: Neuroactive ligand-receptor interaction