Thymine DNA glycosylase (TDG) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI3C11]

CAT#: TA808610BM

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TDG mouse monoclonal antibody, clone OTI3C11 (formerly 3C11), HRP conjugated



  View other "OTI3C11" antibodies (4)

USD 462.00


Availability*
2 Weeks

Size
    • 100 ul


Specifications

Product Data
Clone Name OTI3C11
Applications IHC, WB
Recommended Dilution WB 1:2000, IHC 1:150
Reactivities Human, Mouse, Rat
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Human recombinant protein fragment corresponding to amino acids 160-253 of human TDG(NP_003202) produced in E.coli.
Formulation PBS (pH 7.3) containing 1% BSA, 50% glycerol.
Concentration 0.5 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation HRP
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 45.9 kDa
Gene Name thymine DNA glycosylase
Background The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12. [provided by RefSeq, Jul 2008]
Synonyms hTDG
Reference Data
Protein Families Druggable Genome
Protein Pathways Base excision repair

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