Neurofilament (NEFM) Mouse Monoclonal Antibody (Biotin conjugated) [Clone ID: OTI5B7]

SKU TA805948AM

NEFM mouse monoclonal antibody, clone OTI5B7 (formerly 5B7), Biotinylated

Product Data

• Clone Name: OTI5B7
• Application: IHC, WB
• Recommended Dilution: WB 1:2000, IHC 1:150
• Reactivity: Human
• Antibody Host: Mouse
• Isotype: IgG1
• Clonality: Monoclonal
• Immunogen: Human recombinant protein fragment corresponding to amino acids 413-773 of human NEFM(NP_005373) produced in E.coli.
• Buffer: PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
• Concentration: 0.5 mg/ml
• Purification: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
• Conjugation: Biotin
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Shipping: Blue Ice
• Predicted Protein Size: 102.3 kDa
• Gene Name: neurofilament, medium polypeptide
• Database Link:
  NP_005373
  P07197
• Background: Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
• Synonyms: NEF3; NF-M; NFM

Reference Data

• Protein Pathways: Amyotrophic lateral sclerosis (ALS)