Serum Amyloid A (SAA1) Biotinylated Mouse Monoclonal Detection Antibody (Biotin conjugated) [Clone ID: OTI7A4]
$447.00
2 Weeks*
Specifications
| Product Data | |
| Clone Name | OTI7A4 |
|---|---|
| Application | ELISA |
| Reactivity | Human |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Human recombinant protein fragment of human SAA (NP_954630) produced in E.coli. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 0.5mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Biotin |
| Shipping | Blue Ice |
| Predicted Protein Size | 13.5 kDa |
| Gene Name | serum amyloid A1 |
| Database Link | |
| Background | Serum amyloid A1 (SAA1) is a protein that in humans is encoded by the SAA1 gene. SAA1 is a major acute-phase protein mainly produced by hepatocytes in response to infection, tissue injury and malignancy. When released into blood circulation, SAA1 is present as an apolipoprotein associated with high-density lipoprotein (HDL). SAA1 is a major precursor of amyloid A (AA), the deposit of which leads to inflammatory amyloidosis. Mature SAA1 consists of 104 amino acids with an apparent molecular weight of 12,500. Native SAA1 is a hexamer with each subunit assuming an antiparallel 4-helix bundle structure. SAA1 is highly inducible. Inflammatory cytokines such as IL-1β, IL-6 and TNF-α are major stimulants for hepatocyte expression of the SAA1 gene. Inducible expression of the acute-phase SAA genes involves the transcription factors C/EBP, NF-κB, AP2, SAF, Sp1 and STAT3. SAA1 has been a clinical indicator and reliable biomarker for inflammatory diseases, chronic metabolic disorders and late-stage malignancy. |
| Synonyms | PIG4; SAA; SAA2; TP53I4 |
| Matched ELISA Pair | TA600569 |
| Reference Data | |
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.
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