PD L1 (CD274) Rabbit Monoclonal Antibody [Clone ID: OR-5H8]

USD 428.00


Availability*
In Stock

Size
    • 100 ul


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Specifications

Product Data
Clone Name OR-5H8
Applications IHC
Recommended Dilution IHC: 1:50-1:200
Reactivity Human
Host Rabbit
Isotype IgG
Clonality Monoclonal
Immunogen Synthetic peptide within Human PD-L1 C-terminal. The exact sequence is proprietary.
Formulation Tissue culture buffer containing 1% BSA and 0.02% Sodium azide
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 34 kDa
Gene Name CD274 molecule
Background This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Synonyms B7-H; B7H1; PD-L1; PDCD1L1; PDCD1LG1; PDL1
Reference Data
Protein Families Druggable Genome, Transmembrane
Protein Pathways Cell adhesion molecules (CAMs)

Citations (1)

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