IL6R Mouse Monoclonal Antibody [Clone ID: OTI2F4]

CAT#: TA506859

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IL6R mouse monoclonal antibody, clone OTI2F4 (formerly 2F4)



  View other "OTI2F4" antibodies (4)

Special Offer: Try sample size of this antibody at $99/€99. Use code “TrueSample”.

USD 446.00


Availability*
In Stock

Size
    • 100 ul


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Specifications

Product Data
Clone Name OTI2F4
Applications IF, IHC, WB
Recommended Dilution WB 1:4000, IHC 1:150, IF 1:100
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Full length human recombinant protein of human IL6R(NP_000556) produced in HEK293T cell.
Formulation PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 49.8 kDa
Gene Name interleukin 6 receptor
Background This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, May 2011]
Synonyms CD126; gp80; IL-6R-1; IL-6RA; IL6Q; IL6RA; IL6RQ
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Jak-STAT signaling pathway

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