Bcl x (BCL2L1) Mouse Monoclonal Antibody [Clone ID: OTI2D1]

SKU
TA506188S
BCL2L1 mouse monoclonal antibody, clone OTI2D1 (formerly 2D1)
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$200.00
In Stock*
Specifications
Product Data
Clone Name OTI2D1
Application IHC, WB
Recommended Dilution WB 1:1000, IHC 1:150
Reactivity Human, Mouse, Rat
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Full length human recombinant protein of human BCL2L1(NP_612815) produced in HEK293T cell.
Buffer PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 25.9 kDa
Gene Name BCL2 like 1
Database Link
Background The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq, Jul 2008]
Synonyms Bcl-X; BCL-XL/S; BCL2L; BCLX; PPP1R52
Reference Data
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways Amyotrophic lateral sclerosis (ALS), Apoptosis, Chronic myeloid leukemia, Jak-STAT signaling pathway, Pancreatic cancer, Pathways in cancer, Small cell lung cancer
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SKU Description Size Price
CF506188 Carrier-free (BSA/glycerol-free) BCL2L1 mouse monoclonal antibody, clone OTI2D1 (formerly 2D1) 100 ug
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Citations

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