MEK2 (MAP2K2) Mouse Monoclonal Antibody [Clone ID: OTI1A2]

SKU
TA505680
MAP2K2 (MEK2 ) mouse monoclonal antibody, clone OTI1A2 (formerly 1A2)
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$447.00
In Stock*
Specifications
Product Data
Clone Name OTI1A2
Application IF, IHC, WB
Recommended Dilution WB 1:200~4000, IHC 1:150, IF 1:100
Reactivity Dog, Human, Monkey, Mouse, Rat
Antibody Host Mouse
Isotype IgG2a
Clonality Monoclonal
Immunogen Full length human recombinant protein of human MAP2K2(NP_109587) produced in HEK293T cell.
Buffer PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 44.2 kDa
Gene Name mitogen-activated protein kinase kinase 2
Database Link
Background The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008]
Synonyms CFC4; MAPKK2; MEK2; MKK2; PRKMK2
Reference Data
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Acute myeloid leukemia, B cell receptor signaling pathway, Bladder cancer, Chronic myeloid leukemia, Endometrial cancer, ErbB signaling pathway, Fc epsilon RI signaling pathway, Gap junction, Glioma, GnRH signaling pathway, Insulin signaling pathway, Long-term depression, Long-term potentiation, MAPK signaling pathway, Melanogenesis, Melanoma, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Non-small cell lung cancer, Pathways in cancer, Prion diseases, Prostate cancer, Regulation of actin cytoskeleton, Renal cell carcinoma, T cell receptor signaling pathway, Thyroid cancer, Toll-like receptor signaling pathway, Vascular smooth muscle contraction, VEGF signaling pathway
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SKU Description Size Price
CF505680 Carrier-free (BSA/glycerol-free) MAP2K2 mouse monoclonal antibody, clone OTI1A2 (formerly 1A2) 100 ug
$600.00
TA505680AM MAP2K2 mouse monoclonal antibody,clone 1A2, Biotinylated 100 ul
$509.00
TA505680BM MAP2K2 mouse monoclonal antibody,clone 1A2, HRP conjugated 100 ul
$509.00
TA505680S MAP2K2 (MEK2 ) mouse monoclonal antibody, clone OTI1A2 (formerly 1A2) 30 ul
$200.00

Citations

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