alpha A Crystallin (CRYAA) Mouse Monoclonal Antibody [Clone ID: OTI2C3]
SKU
TA505453S
CRYAA mouse monoclonal antibody,clone OTI2C3
-
TrueMAB™
Antibodies made against full-length proteins as antigens.
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Product Data | |
Clone Name | OTI2C3 |
---|---|
Application | IHC, WB |
Recommended Dilution | WB 1:2000, IHC 1:150 |
Reactivity | Human, Mouse, Rat |
Antibody Host | Mouse |
Isotype | IgG2b |
Clonality | Monoclonal |
Immunogen | Full length human recombinant protein of human CRYAA(NP_000385) produced in HEK293T cell. |
Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
Concentration | 1 mg/ml |
Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
Conjugation | Unconjugated |
Storage | Store at -20°C as received. |
Stability | Stable for 12 months from date of receipt. |
Shipping | Blue Ice |
Predicted Protein Size | 19.7 kDa |
Gene Name | crystallin alpha A |
Database Link | |
Background | Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha crystallins are composed of two gene products: alpha-A and alpha-B, for acidic and basic, respectively. Alpha crystallins can be induced by heat shock and are members of the small heat shock protein (sHSP also known as the HSP20) family. They act as molecular chaperones although they do not renature proteins and release them in the fashion of a true chaperone; instead they hold them in large soluble aggregates. Post-translational modifications decrease the ability to chaperone. These heterogeneous aggregates consist of 30-40 subunits; the alpha-A and alpha-B subunits have a 3:1 ratio, respectively. Two additional functions of alpha crystallins are an autokinase activity and participation in the intracellular architecture. Alpha-A and alpha-B gene products are differentially expressed; alpha-A is preferentially restricted to the lens and alpha-B is expressed widely in many tissues and organs. Defects in this gene cause autosomal dominant congenital cataract (ADCC). [provided by RefSeq, Jul 2008] |
Synonyms | CRYA1; CTRCT9; HSPB4 |
Reference Data |
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Antibody Resources |
SKU | Description | Size | Price | |
---|---|---|---|---|
CF505453 | Carrier-free (BSA/glycerol-free) CRYAA mouse monoclonal antibody,clone OTI2C3 | 100 ug |
$600.00
|
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TA505453 | CRYAA mouse monoclonal antibody,clone OTI2C3 | 100 ul |
$447.00
|
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TA505453AM | CRYAA mouse monoclonal antibody,clone 2C3, Biotinylated | 100 ul |
$509.00
|
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TA505453BM | CRYAA mouse monoclonal antibody,clone 2C3, HRP conjugated | 100 ul |
$509.00
|
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Citations
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen
complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.