AKT1 Mouse Monoclonal Antibody [Clone ID: OTI4D6]
AKT1 mouse monoclonal antibody, clone OTI4D6 (formerly 4D6)
Product Datasheet for 'TA504230'
|Applications||FC, IF, IHC, WB|
|Recommend Dilution||WB 1:500~2000, IHC 1:150, IF 1:100, FLOW 1:100|
|Reactivity||Human, Monkey, Mouse, Rat, Dog|
|Immunogen||Full length human recombinant protein of human AKT1(NP_005154) produced in HEK293T cell.|
|Formulation||PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purification||Purified from cell culture supernatant by affinity chromatography|
|Gene Name||AKT serine/threonine kinase 1|
|Background||The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq]|
|Synonyms||AKT; CWS6; PKB; PKB-ALPHA; PRKBA; RAC; RAC-ALPHA|
|Note||This antibody also cross-reacts with AKT3.|
|Protein Families||Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase|
|Protein Pathways||Acute myeloid leukemia, Adipocytokine signaling pathway, Apoptosis, B cell receptor signaling pathway, Chemokine signaling pathway, Chronic myeloid leukemia, Colorectal cancer, Endometrial cancer, ErbB signaling pathway, Fc epsilon RI signaling pathway, Fc gamma R-mediated phagocytosis, Focal adhesion, Glioma, Insulin signaling pathway, Jak-STAT signaling pathway, MAPK signaling pathway, Melanoma, mTOR signaling pathway, Neurotrophin signaling pathway, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Progesterone-mediated oocyte maturation, Prostate cancer, Renal cell carcinoma, Small cell lung cancer, T cell receptor signaling pathway, Tight junction, Toll-like receptor signaling pathway, VEGF signaling pathway|
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.