FADD Mouse Monoclonal Antibody [Clone ID: OTI1C11]

CAT#: TA501434

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Anti-FADD mouse monoclonal antibody, clone OTI1C11 (formerly 1C11)



  View other "OTI1C11" antibodies (4)

Special Offer: Try sample size of this antibody at $99/€99. Use code "TrueSample".

USD 478.00


Availability*
In Stock

Size
    • 100 ul


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Specifications

Product Data
Clone Name OTI1C11
Applications FC, WB
Recommended Dilution WB 1:2000, FLOW 1:100
Reactivities Human
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Full length human recombinant protein of human FADD (NP_003815) produced in HEK293T cell.
Formulation PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 23.1 kDa
Gene Name Fas associated via death domain
Background The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq]
Synonyms GIG3; MORT1
Reference Data
Protein Families Druggable Genome
Protein Pathways Alzheimer's disease, Apoptosis, Pathways in cancer, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway

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