TRPM4 Mouse Monoclonal Antibody [Clone ID: OTI10H5]

CAT#: TA500381

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TRPM4 mouse monoclonal antibody, clone OTI10H5 (formerly 10H5)

Size: 30 ul 100 ul

Formulation: Standard Carrier-Free

Conjugation: Unconjugated Biotin HRP



USD 478.00

In Stock*

Size
    • 100 ul

Frequently bought together (3)
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Specifications

Product Data
Clone Name OTI10H5
Applications IHC, WB
Recommended Dilution WB 1:5000~10000, IHC 1:50
Reactivities Human, Dog, Monkey
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Full length human recombinant protein of human TRPM4 (NP_060106) produced in HEK293T cell.
Formulation PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Predicted Protein Size 134.3 kDa
Gene Name transient receptor potential cation channel subfamily M member 4
Background Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload.
Synonyms hTRPM4; LTrpC4; PFHB1B; TRPM4B
Reference Data
Protein Families Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane
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