TRPM4 Mouse Monoclonal Antibody [Clone ID: OTI10H5]
TRPM4 mouse monoclonal antibody, clone OTI10H5 (formerly 10H5)
Product Datasheet for 'TA500381'
|Recommend Dilution||WB 1:5000~10000, IHC 1:50|
|Reactivity||Human, Monkey, Dog|
|Immunogen||Full length human recombinant protein of human TRPM4 (NP_060106) produced in HEK293T cell.|
|Formulation||PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purification||Purified from cell culture supernatant by affinity chromatography|
|Predicted Protein Size||134.3 kDa|
|Gene Name||transient receptor potential cation channel subfamily M member 4|
|Background||Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload.|
|Synonyms||hTRPM4; LTrpC4; PFHB1B; TRPM4B|
|Protein Families||Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane|
|The use of this Antibodies has been cited in the following citations:|
Subcellular Localization and Activity of TRPM4 in Medial Prefrontal Cortex Layer 2/3
,Riquelme, D;Silva, I;Philp, AM;Huidobro-Toro, JP;Cerda, O;Trimmer, JS;Leiva-Salcedo, E;,
Front Cell Neurosci 2018
,PubMed ID 29440991
Increases in reactive oxygen species enhance vascular endothelial cell migration through a mechanism dependent on the transient receptor potential melastatin 4 ion channel
,Sarmiento, D;Montorfano, I;Cerda, O;CÃ¡ceres, M;Becerra, A;Cabello-Verrugio, C;Elorza, AA;Riedel, C;Tapia, P;VelÃ¡squez, LA;Varela, D;Simon, F;,
Microvasc. Res., Feb 2014.
,PubMed ID 24518820
Transient receptor potential melastatin 4 inhibition prevents lipopolysaccharide-induced endothelial cell death
,Alvaro Becerra, Cesar Echeverría, Diego Varela, Daniela Sarmiento, Ricardo Armisén, Felipe Nuñez-Villena, Mario Montecinos, and Felipe Simon,
Cardiovasc Res, Sep 2011; 91: 677 - 684.
,PubMed ID 21565835
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