TRPM4 Mouse Monoclonal Antibody [Clone ID: OTI10H5]

CAT#: TA500381

TRPM4 mouse monoclonal antibody, clone OTI10H5 (formerly 10H5)

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 Product Datasheet for 'TA500381'

USD 379.00

In Stock

    • 100 ul


Product Data
Clone Name OTI10H5
Applications WB, IHC
Recommend Dilution WB 1:5000~10000, IHC 1:50,
Reactivity Human , Dog , Monkey
Host Mouse
Clonality Monoclonal
Immunogen Full length human recombinant protein of human TRPM4 (NP_060106) produced in HEK293T cell.
Isotype IgG1
Formulation PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 1.00mg/ml
Purification Purified from cell culture supernatant by affinity chromatography
Predicted Protein Size 134.3 kDa
Gene Name transient receptor potential cation channel subfamily M member 4
Background Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload.
Synonyms LTrpC4|PFHB1B|TRPM4B|hTRPM4
Reference Data
Protein Families Ion Channels: Transient receptor potential, Transmembrane, Druggable Genome
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