LATS1 Rabbit Monoclonal Antibody
| Product Data | |
| Application | ELISA, WB |
|---|---|
| Recommended Dilution | WB,1:1000 - 1:2000 ELISA,Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements. |
| Reactivity | Human |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Monoclonal |
| Buffer | 59% PBS with 0.01% Sodium azide, 0.05% BSA, 40% Glycerol, pH 7.2 |
| Concentration | lot specific |
| Purification | Affinity purification |
| Conjugation | Unconjugated |
| Storage | Store at -20℃. Avoid freeze / thaw cycles. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 127kDa |
| Background | The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. |
| Reference Data | |
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complexities in the preparation of your product. International customers may expect an additional 1-2 weeks
in shipping.