WRN Rabbit Monoclonal Antibody
| Product Data | |
| Application | WB |
|---|---|
| Recommended Dilution | WB 1:500~1:2000 |
| Reactivity | Human |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Monoclonal |
| Immunogen | A synthesized peptide derived from human WRN |
| Specificity | WRN Antibody detects endogenous levels of total WRN |
| Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Concentration | lot specific |
| Purification | Affinity-chromatography |
| Conjugation | Unconjugated |
| Storage | Store at +4°C short term. Store at -23°C long term. Avoid freeze / thaw cycle. |
| Shipping | Blue Ice |
| Predicted Protein Size | 200kDa |
| Gene Name | Werner syndrome RecQ like helicase |
| Database Link | |
| Background | Multifunctional enzyme that has both magnesium and ATP-dependent DNA-helicase activity and 3'->5' exonuclease activity towards double-stranded DNA with a 5'-overhang. Has no nuclease activity towards single-stranded DNA or blunt-ended double-stranded DNA. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. |
| Synonyms | Exonuclease WRN; RecQ3; RECQL2; RECQL3; Werner syndrome helicase; WRN |
| Reference Data | |
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