Caspase 9 (CASP9) Rabbit Monoclonal Antibody
| Product Data | |
| Application | IP, WB |
|---|---|
| Recommended Dilution | WB 1:500~1:2000 IP 1:50 |
| Reactivity | Human, Mouse |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Monoclonal |
| Immunogen | A synthesized peptide derived from human cleaved Caspase-9 |
| Specificity | cleaved Caspase-9 Antibody detects endogenous levels of cleaved Caspase-9 |
| Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Concentration | lot specific |
| Purification | Affinity-chromatography |
| Conjugation | Unconjugated |
| Storage | Store at +4°C short term. Store at -23°C long term. Avoid freeze / thaw cycle. |
| Shipping | Blue Ice |
| Predicted Protein Size | 46,39,37,35kDa |
| Gene Name | caspase 9 |
| Database Link | |
| Background | Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9. |
| Synonyms | APAF-3; APAF3; CASP9; Caspase-9; Caspase 9 Dominant Negative; ICE-LAP6; MCH6; PPP1R56 |
| Reference Data | |
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