Tau (MAPT) Rabbit Monoclonal Antibody

SKU TA422586

Phospho-Tau (T231) Antibody

Product Data

• Application: IHC, IP, WB
• Recommended Dilution: WB 1:500~1:2000 IHC 1:50~1:200 IP 1:50
• Reactivity: Human, Mouse, Rat
• Antibody Host: Rabbit
• Isotype: IgG
• Clonality: Monoclonal
• Immunogen: A synthesized peptide derived from human Phospho-Tau (T231)
• Specificity: Phospho-Tau (T231) Antibody detects endogenous levels of Phospho-Tau (T231)
• Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: lot specific
• Purification: Affinity-chromatography
• Conjugation: Unconjugated
• Storage: Store at +4°C short term. Store at -22°C long term. Avoid freeze / thaw cycle.
• Shipping: Blue Ice
• Predicted Protein Size: 46kDa
• Gene Name: microtubule associated protein tau
• Database Link:
  P10636
• Background: Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5. Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau.
• Synonyms: MAPT; Microtubule-associated protein tau; MTBT1; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau

Reference Data