ROCK1 Rabbit Monoclonal Antibody
| Product Data | |
| Application | FC, ICC/IF, IHC, IP, WB |
|---|---|
| Recommended Dilution | WB 1:500~1:2000 IHC 1:50~1:200 ICC/IF 1:50~1:200 IP 1:50 FC 1:50 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Monoclonal |
| Immunogen | A synthesized peptide derived from human ROCK1 |
| Specificity | ROCK1 Antibody detects endogenous levels of total ROCK1 |
| Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Concentration | lot specific |
| Purification | Affinity-chromatography |
| Conjugation | Unconjugated |
| Storage | Store at +4°C short term. Store at -23°C long term. Avoid freeze / thaw cycle. |
| Shipping | Blue Ice |
| Predicted Protein Size | 158kDa |
| Gene Name | Rho associated coiled-coil containing protein kinase 1 |
| Database Link | |
| Background | ROCK1 Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. |
| Synonyms | p160 ROCK-1; p160-ROCK; p160ROCK; PRO0435; Renal carcinoma antigen NY-REN-35; Rho-associated protein kinase 1; Rho kinase |
| Reference Data | |
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