Torsin A (TOR1A) Rabbit Monoclonal Antibody
| Product Data | |
| Application | FC, WB |
|---|---|
| Recommended Dilution | WB 1:500~1:2000 FC 1:50 |
| Reactivity | Human |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Monoclonal |
| Immunogen | A synthesized peptide derived from human Torsin A |
| Specificity | Torsin A Antibody detects endogenous levels of total Torsin A |
| Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Concentration | lot specific |
| Purification | Affinity-chromatography |
| Conjugation | Unconjugated |
| Storage | Store at +4°C short term. Store at -24°C long term. Avoid freeze / thaw cycle. |
| Shipping | Blue Ice |
| Predicted Protein Size | 35kDa |
| Gene Name | torsin family 1 member A |
| Database Link | |
| Background | The neurological condition Dystonia is associated with sustained muscle contractions and abnormal posturing. TorsinA, torsinB, torp2A and torp3A belong to the family of ATPases associated with cellular activites (AAA+) and mutations in torsinA cause early onset dystonia. TorsinA has been shown to suppress intracellular protein aggregation in C. elegans and possesses chaperon activity. Interestingly, torsinA is highly expressed in dopaminergic neurons and associates with alpha-synuclein in Lewy bodies, which pathologically characterize Parkinson's Disease. |
| Synonyms | DQ2; DYT1; TOR1A; TorsinA |
| Reference Data | |
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