Estrogen Receptor 1 (ESR1) Rabbit Monoclonal Antibody
| Product Data | |
| Application | ChIP, FC, ICC/IF, IHC, WB |
|---|---|
| Recommended Dilution | WB 1:500~1:2000 IHC 1:50~1:100 ICC/IF 1:50~1:100 ChIP 5 ?g/30 ?g FC 1:30 |
| Reactivity | Dog, Human, Mouse, Rat |
| Antibody Host | Rabbit |
| Isotype | IgG |
| Clonality | Monoclonal |
| Immunogen | A synthesized peptide derived from human ER alpha |
| Specificity | ER alpha Antibody detects endogenous levels of total ER alpha |
| Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Concentration | lot specific |
| Purification | Affinity-chromatography |
| Conjugation | Unconjugated |
| Storage | Store at +4°C short term. Store at -23°C long term. Avoid freeze / thaw cycle. |
| Shipping | Blue Ice |
| Predicted Protein Size | 60kDa |
| Gene Name | estrogen receptor 1 |
| Database Link | |
| Background | ER (estrogen receptor 1) a member of the steroid receptor superfamily, contains highly conserved DNA binding (DBD) and ligand binding domains (LBD). Through its estrogen-independent and estrogen-dependent activation domains (AF-1 and AF-2, respectively), ER regulates transcription by recruiting coactivator proteins and interacting with general transcriptional machinery. Phosphorylation provides an important mechanism to regulate ER activity. ER is phosphorylated on multiple sites. |
| Synonyms | ER; Era; ESR; ESR1; ESRA; NR3A1 |
| Reference Data | |
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