PARP1 Rabbit Monoclonal Antibody
Product Data | |
Application | IHC, WB |
---|---|
Recommended Dilution | WB 1:500~1:2000 IHC 1:50~1:100 |
Reactivity | Human, Mouse, Rat |
Antibody Host | Rabbit |
Isotype | IgG |
Clonality | Monoclonal |
Immunogen | A synthesized peptide derived from human Cleaved PARP |
Specificity | This antibody is specific for the p25 cleaved form of human PARP. |
Buffer | Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Concentration | lot specific |
Purification | Affinity-chromatography |
Conjugation | Unconjugated |
Storage | Store at +4°C short term. Store at -21°C long term. Avoid freeze / thaw cycle. |
Shipping | Blue Ice |
Predicted Protein Size | 25kDa |
Gene Name | poly(ADP-ribose) polymerase 1 |
Database Link | |
Background | Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. |
Synonyms | ADPRT; ADPRT1; pADPRT-1; PARP; PARP-1; PPOL |
Reference Data |
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